Toronto Blue Jays vs St Louis Cardinals Prediction, Preview and Odds - 06/10/2025

Game Time: 7:45 pm ET, Tuesday, June 10, 2025

Venue:  Busch Stadium, St. Louis, MO

Where to Watch:  FDSMW

DraftKings:  Moneyline odds:  Blue Jays -121, Cardinals -101; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Blue Jays -120, Cardinals +100; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Blue Jays -120, Cardinals +100; Over/Under:  8.5 runs

Toronto Blue Jays:  35-30 (3rd place, AL East)

St Louis Cardinals:  36-29 (2nd place, NL Central)

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Toronto Blue Jays:  8-2 last 10

St Louis Cardinals:  5-5 last 10

The Blue Jays are entering this series off a loss and won their 3-game series against the Minnesota Twins 2-1 in their last series. They enter this game with a 35-30 record overall and have a road record of 13-17. This is the 2nd game of a 3-game series with the Cardinals on Tuesday with the series opener still to be played on Monday. Their offense ranks 11th in the MLB with a .719 OPS. José Berríos is their starting pitcher on Monday while Chris Bassitt is making his start in this game on Tuesday. He is 6-3 with a 3.56 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 ER, 0 HR, and 2 BB with 6 Ks on 5 hits through 7 IP against the Philadelphia Phillies.

The Cardinals are entering this series off a loss and won their 3-game series against the Los Angeles Dodgers 2-1 in their last series. They enter this game with a 36-29 record overall and have a home record of 22-11. This is the 2nd game of a 3-game series with the Blue Jays on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 9th in the MLB with a .724 OPS. Andre Pallante is their starting pitcher on Monday while Miles Mikolas is making his start in this game on Tuesday. He is 4-2 with a 3.96 ERA this season. His team won their last 7 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 3 earned runs, 1 homer, and 1 BB with 2 strikeouts on 8 hits through 6 innings played against the Kansas City Royals.

The current betting odds have the Blue Jays listed as a slight favorite in this game according to Draftkings Sportsbook. The Blue Jays have looked good in their games this season with their 35-30 record overall which has them right in the middle of the AL East. They haven't been a great road team though with their 13-17 road record. Meanwhile, the Cardinals have looked good in their games this season with their 36-29 record overall which has them right near the top of the NL Central. They have also looked a lot better in their own ballpark this year with their 22-11 home record. The Cardinals were really hot coming into June, but now they are 5-5 in their last 10 games while the Blue Jays are 8-2 in their last 10 and have been the hotter team lately. Bassitt is on the mound for the Blue Jays in this one and he is 6-3 with a 3.56 ERA. He has looked great in his starts lately as he hasn't been giving up many runs at all, only giving up 1 earned run in his last start, and the team has won 2 games in a row now with him starting too. The Cardinals are going with Mikolas in this one and he hasn't looked as good this season. He is 4-2 with a 3.96 ERA and the team has had a ton of success with him on the mound, winning 7 games in a row now with him starting, but he did give up 3 earned runs in his last start and that has been a common theme for him. The Blue Jays have also been rolling on offense lately and they have a much better offense this season than the Cardinals do. The best way to place a bet here is on the Blue Jays to win this game. 

Blue Jays Cardinals Prediction:  Our MLB Pick for Tuesday, June 10, 2025 (7:45 pm ET start time) is Blue Jays 5 Cardinals 4.

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Toronto Blue Jays: 197-193 (-24.1 units) on the moneyline in all games. 118-97 (-21.9 units) on the moneyline as a favorite of -110 or higher. 155-149 (-15.6 units) on the moneyline against right-handed starters. 23-17 OVER vs. a team slugging percentage .400 or worse on the season (NL). 

St Louis Cardinals: 22-14 (+12.9 units) on the moneyline against AL East opponents. 92-99 (+18.1 units) on the moneyline as an underdog of +100 or higher. 57-50 (+6.7 units) on the moneyline at home when the money line is +125 to -125. 23-15 OVER vs. an AL starting pitcher whose ERA is 3.70 or better.

Toronto Blue Jays:  D. Varsho (CF) Ten Day IL - Hamstring. A. Santander (RF) Ten Day IL - Shoulder. Y. Garcia (RP) Fifteen Day IL - Shoulder. M. Scherzer (SP) Sixty Day IL - Thumb. R. Burr (RP) Sixty Day IL - Shoulder. N. Sandlin (RP) Fifteen Day IL - Back. A. Manoah (SP) Sixty Day IL - Elbow. A. Bastardo (SP) Sixty Day IL - Elbow.

St Louis Cardinals:  M. Liberatore (SP) Day To Day - Fatigue. J. Walker (RF) Ten Day IL - Wrist. Z. Thompson (RP) Sixty Day IL - Lat.

“Early, I thought his stuff was good and he was just missing. They wore him down, basically. The walks are going to hurt you. I thought early his stuff was as it should be, and just the close misses and the walks end up catching up to you.” - John Schneider after his team’s loss against the Twins in their game on Sunday.

“You are learning and developing winning players, and that’s what I’m loving at the moment. These guys are learning how to win. I’ve said it quite a bit -- that’s a good team across the way and [the Dodgers] felt us every inning of this series. Even up four [runs], you can feel it. That’s exactly the type of pressure and culture you want to create -- regardless of score and regardless of inning, they feel you coming. That’s exactly what this series was. I enjoyed the heck out of it.” - Oliver Marmol after his team’s loss against the LA Dodgers in their game on Sunday.

Bo Bichette (R) SS

Vladimir Guerrero Jr. (R) 1B

Addison Barger (L) 3B

Alejandro Kirk (R) C

George Springer (R) DH

Nathan Lukes (L) RF

Ernie Clement (R) 2B

Alan Roden (L) LF

Myles Straw (R) CF

Lars Nootbaar (L) LF

Masyn Winn (R) SS

Brendan Donovan (L) 2B

Willson Contreras (R) 1B

Iván Herrera (R) DH

Nolan Arenado (R) 3B

Alec Burleson (L) RF

Pedro Pagés (R) C

Jose Barrero (R) CF

Batting Average:  Tyler Heineman (.429)

Hits:  Bo Bichette (74)

Home Runs:  George Springer (10)

RBI:  Bo Bichette (37)

Stolen Bases:  Andrés Giménez (9)

Wins:  Chris Bassitt (6)

Saves:  Jeff Hoffman (15)

ERA:  Brendon Little (1.55)

Batting Average:  Thomas Saggese (.341)

Hits:  Brendan Donovan (76)

Home Runs:  Lars Nootbaar (8)

RBI:  Willson Contreras (38)

Stolen Bases:  Victor Scott (17)

Wins:  Sonny Gray (7)

Saves:  Ryan Helsley (13)

ERA:  Phil Maton (2.25)

Managers:

Toronto Blue Jays: John Schneider (4th season)

St Louis Cardinals: Oliver Marmol (4th season)