Toronto Blue Jays vs Cleveland Guardians Prediction, Preview and Odds - 06/24/2025

Game Time: 6:40 pm ET, Tuesday, June 24, 2025

Venue:  Progressive Field, Cleveland, OH

Where to Watch:  Sportsnet, CLEGUARDIANS.tv

DraftKings:  Moneyline odds:  Blue Jays -108, Guardians -112; Over/Under:  9 runs

Bet365:  Moneyline odds:  Blue Jays -110, Guardians -110; Over/Under:  9 runs

BetMGM:  Moneyline odds:  Blue Jays -110, Guardians -110; Over/Under:  9 runs

Toronto Blue Jays:  41-36 (3rd place, AL East)

Cleveland Guardians:  39-37 (2nd place, AL Central)

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Toronto Blue Jays:  4-6 last 10

Cleveland Guardians:  5-5 last 10

The Blue Jays are entering this series off a loss and lost their 3-game series against the Chicago White Sox 2-1 in their last series. They enter this game with a 41-36 record overall and have a road record of 16-20. This is the series opener of a 3-game series with the Guardians on Tuesday and they have Monday off as a day of rest. Their offense ranks 12th in the MLB with a .725 OPS. Chris Bassitt was their starting pitcher on Sunday while Eric Lauer is making his start in this game on Tuesday. He is 3-1 with a 2.29 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 ER, 0 HR, and 1 BB with 8 SO on 4 hits through 5 IP against the Arizona Diamondbacks.

The Guardians are entering this series off a win and won their 3-game series against the Athletics 2-1 in their last series. They enter this game with a 39-37 record overall and have a home record of 19-15. This is the 1st game of a 3-game series with the Blue Jays on Tuesday and they have Monday off as a day of rest. Their offense ranks 27th in the MLB with a .670 OPS. Slade Cecconi was their starting pitcher on Sunday while Logan Allen is making his start in this game on Tuesday. He is 5-4 with a 4.21 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 1 homer, and 2 walks with 4 strikeouts on 4 hits through 5.1 innings pitched against the San Francisco Giants.

The current betting odds have the Blue Jays listed as a slight underdog in this game according to Draftkings Sportsbook. The Blue Jays have looked good in their games this season with their 41-36 record overall which has them right in the middle of the AL East. They haven't been a great road team though with their 16-20 road record. Meanwhile, the Guardians have looked good in their games this season with their 39-37 record overall which has them right in the middle of the AL Central. They have looked better in their own ballpark too with their 19-15 home record. Neither team has really been hot coming into this series though and this is a good game for the Blue Jays to bounce back in after a terrible series over the weekend. They are going with Lauer in this one and he has looked great this season. He is 3-1 with a 2.29 ERA and hasn't been giving up many runs all year. He is coming off another great start in which he gave up 1 earned run and the team has won 3 games in a row now with him starting too. The Guardians are going with Allen in this one and he has looked good lately, but he has also been really up and down all year and isn't that reliable. He is 5-4 with a 4.21 ERA and only gave up 2 earned runs in his last start, but that hasn't been a common theme for him. His team has won 2 games in a row now with him starting, but the Blue Jays have the much better offense to get to him in this game and that should give the Jays the edge in this one. The best way to place a bet here is on the Blue Jays to win this game. 

Blue Jays Guardians Prediction:  Our MLB Pick for Tuesday, June 24, 2025 (6:40 pm ET start time) is Blue Jays 4 Guardians 1.

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Toronto Blue Jays: 40-38 (-9 units) on the moneyline against AL Central opponents. 203-199 (-26.1 units) on the moneyline in all games. 81-77 (-14.9 units) on the moneyline when the money line is -100 to -150. 47-28 UNDER against AL Central opponents.

Cleveland Guardians: 42-43 (+4.7 units) on the moneyline against AL East opponents. 114-86 (+10 units) on the moneyline in home games. 98-70 (+10.9 units) on the moneyline when the money line is -100 to -150. 172-122 UNDER vs. good fielding teams - averaging 0.6 errors/game or less.

Toronto Blue Jays:  B. Francis (SP) Fifteen Day IL - Shoulder. D. Varsho (CF) Ten Day IL - Hamstring. A. Santander (RF) Ten Day IL - Shoulder. Y. Garcia (RP) Fifteen Day IL - Shoulder. M. Scherzer (SP) Sixty Day IL - Thumb. R. Burr (RP) Sixty Day IL - Shoulder. A. Manoah (SP) Sixty Day IL - Elbow. A. Bastardo (SP) Sixty Day IL - Elbow.

Cleveland Guardians:  A. Walters (RP) Sixty Day IL - Lat. B. Lively (SP) Sixty Day IL - Forearm. W. Brennan (RF) Ten Day IL - Forearm. P. Sewald (RP) Fifteen Day IL - Shoulder. S. Bieber (SP) Sixty Day IL - Elbow. E. Sabrowski (RP) Sixty Day IL - Elbow. T. Stephan (RP) Sixty Day IL - Elbow. J. Means (SP) Sixty Day IL - Elbow. S. Hentges (RP) Sixty Day IL - Shoulder.

“That’s a huge, huge addition for us. That’s Max Scherzer. I’ll take that any day of the week.” - John Schneider on Max Scherzer coming back in this series. 

“Slade pitched today. He got quick outs, got some punchouts when he needed to, and it just seemed like he wasn't slowing down.” - Stephen Vogt after his team’s win against the Athletics in their game on Sunday.

Bo Bichette (R) SS

Addison Barger (L) 3B

Vladimir Guerrero Jr. (R) DH

Alejandro Kirk (R) C

Nathan Lukes (L) RF

Ernie Clement (R) 1B

Andrés Giménez (L) 2B

Myles Straw (R) CF

Alan Roden (L) LF

Steven Kwan (L) LF

Lane Thomas (R) CF

José Ramírez (S) 3B

David Fry (R) DH

Kyle Manzardo (L) 1B

Angel Martínez (S) 2B

Gabriel Arias (R) SS

Nolan Jones (L) RF

Austin Hedges (R) C

Batting Average:  Tyler Heineman (.394)

Hits:  Bo Bichette (91)

Home Runs:  Bo Bichette (11)

RBI:  Bo Bichette (48)

Stolen Bases:  Andrés Giménez (9)

Wins:  Chris Bassitt (7)

Saves:  Jeff Hoffman (17)

ERA:  Justin Bruihl (0.00)

Batting Average:  José Ramírez (.323)

Hits:  José Ramírez (90)

Home Runs:  José Ramírez (13)

RBI:  Carlos Santana (36)

Stolen Bases:  José Ramírez (20)

Wins:  Gavin Williams (5)

Saves:  Emmanuel Clase (18)

ERA:  Kolby Allard (1.95)

Managers:

Toronto Blue Jays: John Schneider (4th season)

Cleveland Guardians: Stephen Vogt (2nd season)