Seattle Mariners vs Chicago Cubs Prediction, Preview and Odds - 06/21/2025

Game Time: 2:20 pm ET, Saturday, June 21, 2025

Venue:  Wrigley Field, Chicago, IL

Where to Watch:  MARQ

DraftKings:  Moneyline odds:  Mariners +144, Cubs -176; Over/Under:  NL runs

Bet365:  Moneyline odds:  Mariners +145, Cubs -175; Over/Under:  NL runs

BetMGM:  Moneyline odds:  Mariners +145, Cubs -175; Over/Under:  NL runs

Seattle Mariners:  37-36 (2nd place, AL West)

Chicago Cubs:  45-29 (1st place, NL Central)

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Seattle Mariners:  5-5 last 10

Chicago Cubs:  5-5 last 10

The Mariners are entering this series off a loss and lost their 3-game series against the Boston Red Sox 2-1 in their last series. They enter this game with a 37-36 record overall and have a road record of 17-17. This is the 2nd game of a 3-game series with the Cubs on Saturday with the series opener still to be played on Friday. Their offense ranks 15th in the MLB with a .716 OPS. George Kirby is their starting pitcher on Friday while Emerson Hancock is making his start in this game on Saturday. He is 3-2 with a 4.48 ERA this season. His team lost 3 of their last 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 0 ER, 0 HR, and 1 BB with 4 SO on 2 hits through 7 IP against the Cleveland Guardians.

The Cubs are entering this series off a loss and split their 2-game series against the Milwaukee Brewers 1-1 in their last series. They enter this game with a 45-29 record overall and have a home record of 24-13. This is the 2nd game of a 3-game series with the Mariners on Saturday with the 1st game of this series still to be played on Friday. Their offense ranks 4th in the MLB with a .761 OPS. Matthew Boyd is their starting pitcher on Friday while rookie pitcher Cade Horton is making his start in this game on Saturday. He is 3-1 with a 3.47 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 1 walk with 4 strikeouts on 3 hits through 5.2 innings pitched against the Pittsburgh Pirates.

The current betting odds have the Cubs listed as a favorite in this game according to Draftkings Sportsbook. The Cubs have looked great in their games this season with their 45-29 record overall which has them right at the top of the NL Central with one of the best records in the entire MLB. They have also looked great in their own ballpark this year with their 24-13 home record. Meanwhile, the Mariners have looked good in their games this season with their 37-36 record overall which has them right near the top of the AL West. They haven't been a great road team though with their 17-17 road record this season. Neither team has been hot coming into this series, but the Cubs do have the much better offense this season and can use that to edge out the Mariners at home here. The Mariners are going with Hancock in this one and he hasn't looked great this season. He is 3-2 with a 4.48 ERA and he is coming off a good start in which he gave up no runs, but that hasn't been a common theme for him this year. He has been giving up quite a few runs in most of his starts this season and even the team has lost 3 of their last 4 games with him starting. The Cubs are going with Horton in this one and he is in his rookie season, but he hasn't looked bad this year. He is 3-1 with a 3.47 ERA and he hasn't been giving up many runs this year. His team has lost 2 games in a row with him starting, but he gave up no runs in his last start and he has one of the best offenses in the MLB to help him out here too. The best way to place a bet here is on the Cubs to win this game. 

Mariners Cubs Prediction:  Our MLB Pick for Saturday, June 21, 2025 (2:20 pm ET start time) is Cubs 5 Mariners 2.

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Seattle Mariners: 16-17 (-4.6 units) on the moneyline against NL Central opponents. 209-187 (-19.2 units) on the moneyline in all games. 96-100 (-11.9 units) on the moneyline in road games. 20-12 OVER as a road underdog of +125 to +175.

Chicago Cubs: 21-15 (+4.7 units) on the moneyline against AL West opponents. 211-186 (+14 units) on the moneyline in all games. 113-85 (+13 units) on the moneyline in home games. 36-24 OVER vs. AL teams scoring 4.4 or less runs/game on the season.

Seattle Mariners:  B. Miller (SP) Fifteen Day IL - Elbow. C. Snider (RP) Fifteen Day IL - Forearm. G. Santos (RP) Sixty Day IL - Knee. V. Robles (RF) Sixty Day IL - Shoulder. R. Bliss (2B) Sixty Day IL - Biceps.

Chicago Cubs:  M. Amaya (C) Ten Day IL - Oblique. P. Hodge (RP) Fifteen Day IL - Oblique. E. Morgan (RP) Sixty Day IL - Elbow. S. Imanaga (SP) Fifteen Day IL - Leg. J. Assad (RP) Sixty Day IL - Oblique. J. Steele (SP) Sixty Day IL - Elbow.

“We want to get him healthy first, and get him back out there. Obviously, Luke is a guy that is pretty versatile and can find his way on the field in different ways. And defensively, he does such a great job for us. Offensively, he provides a lot of pop as well. So obviously, a guy you want in the lineup.” - Dan Wilson on the injury to Luke Raley.

“Let’s keep it going. He’s having a great season. Those are nice round numbers, but let’s make them crooked again.” - Craig Counsell on Pete Crow-Armstrong after his team’s loss against the Brewers in their game on Thursday.

J.P. Crawford (L) SS

Julio Rodríguez (R) CF

Cal Raleigh (S) C

Randy Arozarena (R) LF

Mitch Garver (R) DH

Donovan Solano (R) 1B

Dylan Moore (R) RF

Ben Williamson (R) 3B

Cole Young (L) 2B

Ian Happ (S) LF

Kyle Tucker (L) RF

Seiya Suzuki (R) DH

Pete Crow-Armstrong (L) CF

Dansby Swanson (R) SS

Michael Busch (L) 1B

Nico Hoerner (R) 2B

Matt Shaw (R) 3B

Reese McGuire (L) C

Batting Average:  J.P. Crawford (.294)

Hits:  Julio Rodríguez (75)

Home Runs:  Cal Raleigh (27)

RBI:  Cal Raleigh (60)

Stolen Bases:  Randy Arozarena (14)

Wins:  Bryan Woo (6)

Saves:  Andrés Muñoz (18)

ERA:  Matt Brash (0.00)

Batting Average:  Nico Hoerner (.288)

Hits:  Nico Hoerner (78)

Home Runs:  Pete Crow-Armstrong (20)

RBI:  Seiya Suzuki (61)

Stolen Bases:  Pete Crow-Armstrong (23)

Wins:  Jameson Taillon (7)

Saves:  Daniel Palencia (7)

ERA:  Drew Pomeranz (0.00)

Managers:

Seattle Mariners: Dan Wilson (2nd season)

Chicago Cubs: Craig Counsell (2nd season)