Seattle Mariners vs Chicago Cubs Prediction, Preview and Odds - 06/20/2025

Game Time: 2:20 pm ET, Friday, June 20, 2025

Venue:  Wrigley Field, Chicago, IL

Where to Watch:  MLBN

DraftKings:  Moneyline odds:  Mariners +110, Cubs -130; Over/Under:  NL runs

Bet365:  Moneyline odds:  Mariners +110, Cubs -130; Over/Under:  NL runs

BetMGM:  Moneyline odds:  Mariners +110, Cubs -130; Over/Under:  NL runs

Seattle Mariners:  37-36 (2nd place, AL West)

Chicago Cubs:  45-28 (1st place, NL Central)

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Seattle Mariners:  5-5 last 10

Chicago Cubs:  6-4 last 10

The Mariners are entering this series off a loss and lost their 3-game series against the Boston Red Sox 2-1 in their last series. They enter this game with a 37-36 record overall and have a road record of 17-17. This is the series opener of a 3-game series with the Cubs on Friday and they have Thursday off as a day of rest. Their offense ranks 15th in the MLB with a .716 OPS. Luis Castillo was their starting pitcher on Wednesday while George Kirby is making his start in this game on Friday. He is 1-3 with a 5.96 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 2 ER, 1 HR, and 3 BB with 5 SO on 5 hits through 5 IP against the Cleveland Guardians.

The Cubs won their 4-game series against the Pittsburgh Pirates 3-1. They enter this game with a 45-28 record overall and have a home record of 24-12. This is the 1st game of a 3-game series with the Mariners on Friday with the 2nd game of their series against the Milwaukee Brewers still to be played on Thursday. The Cubs won the 1st game of that series on Tuesday. Their offense ranks 4th in the MLB with a .760 OPS. Jameson Taillon is their starting pitcher on Thursday while Matthew Boyd is making his start in this game on Friday. He is 6-3 with a 2.79 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 1 homer, and 1 walk with 3 strikeouts on 1 hit through 6 innings pitched against the Pittsburgh Pirates.

The current betting odds have the Cubs listed as a favorite in this game according to Draftkings Sportsbook. The Cubs have looked great in their games this season with their 45-28 record overall which has them right at the top of the NL Central with one of the best records in the entire MLB. They have also looked great in their own ballpark this year with their 24-12 home record. Meanwhile, the Mariners have looked good in their games this season with their 37-36 record overall which has them right near the top of the AL West. They haven't been a great road team though with their 17-17 road record this season. The Cubs are entering this series as the hotter team lately, going 6-4 in their last 10 games, but they can also take advantage of this pitching matchup. The Mariners are going with Kirby in this one and he hasn't looked great this season. He is 1-3 with a 5.96 ERA and he has been giving up quite a few runs in his starts this year. His team has won 2 games in a row with him starting and he only gave up 2 earned runs in his last start, but that hasn't been a common theme for him this year and he won't pitch as well on the road against one of the best offenses in the MLB. The Cubs are going with their Boyd in this one and he has looked good this season. He is 6-3 with a 2.79 ERA and hasn't given up many runs in his few starts. The team has lost 2 of their last 3 games with him starting, but he only gave up 1 run in his last start so the team will be looking to get him a win here. The Cubs have the better offense and the better pitching matchup to take advantage of. The best way to place a bet here is on the Cubs to win this game. 

Mariners Cubs Prediction:  Our MLB Pick for Friday, June 20, 2025 (2:20 pm ET start time) is Cubs 7 Mariners 3.

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Seattle Mariners: 16-17 (-4.6 units) on the moneyline against NL Central opponents. 209-187 (-19.2 units) on the moneyline in all games. 96-100 (-11.9 units) on the moneyline in road games. 7-4 UNDER on the road vs. an NL starting pitcher whose ERA is 3.20 or better.

Chicago Cubs: 21-15 (+4.7 units) on the moneyline against AL West opponents. 211-185 (+15.2 units) on the moneyline in all games. 113-84 (+14.3 units) on the moneyline in home games. 11-5 UNDER at home vs. a starting pitcher who gives up 1 or more HR's/start.

Seattle Mariners:  B. Miller (SP) Fifteen Day IL - Elbow. C. Snider (RP) Fifteen Day IL - Forearm. L. Raley (RF) Ten Day IL - Side. G. Santos (RP) Sixty Day IL - Knee. V. Robles (RF) Sixty Day IL - Shoulder. R. Bliss (2B) Sixty Day IL - Biceps.

Chicago Cubs:  M. Amaya (C) Ten Day IL - Oblique. P. Hodge (RP) Fifteen Day IL - Oblique. E. Morgan (RP) Sixty Day IL - Elbow. S. Imanaga (SP) Fifteen Day IL - Leg. J. Assad (RP) Sixty Day IL - Oblique. J. Steele (SP) Sixty Day IL - Elbow.

“We want to get him healthy first, and get him back out there. Obviously, Luke is a guy that is pretty versatile and can find his way on the field in different ways. And defensively, he does such a great job for us. Offensively, he provides a lot of pop as well. So obviously, a guy you want in the lineup.” - Dan Wilson on the injury to Luke Raley.

“That’s why we come to the ballpark -- to see things like that, to see great players do great things, great players do amazing things.” - Craig Counsell after his team’s win against the Brewers in their game on Tuesday.

Dylan Moore (R) SS

Julio Rodríguez (R) CF

Cal Raleigh (S) DH

Jorge Polanco (S) 2B

Randy Arozarena (R) LF

Mitch Garver (R) C

Donovan Solano (R) 1B

Ben Williamson (R) 3B

Miles Mastrobuoni (L) RF

Ian Happ (S) LF

Kyle Tucker (L) RF

Seiya Suzuki (R) DH

Pete Crow-Armstrong (L) CF

Dansby Swanson (R) SS

Michael Busch (L) 1B

Carson Kelly (R) C

Nico Hoerner (R) 2B

Matt Shaw (R) 3B

Batting Average:  J.P. Crawford (.294)

Hits:  Julio Rodríguez (75)

Home Runs:  Cal Raleigh (27)

RBI:  Cal Raleigh (60)

Stolen Bases:  Randy Arozarena (14)

Wins:  Bryan Woo (6)

Saves:  Andrés Muñoz (18)

ERA:  Matt Brash (0.00)

Batting Average:  Nico Hoerner (.288)

Hits:  Nico Hoerner (77)

Home Runs:  Pete Crow-Armstrong (19)

RBI:  Seiya Suzuki (61)

Stolen Bases:  Pete Crow-Armstrong (23)

Wins:  Jameson Taillon (7)

Saves:  Daniel Palencia (7)

ERA:  Drew Pomeranz (0.00)

Managers:

Seattle Mariners: Dan Wilson (2nd season)

Chicago Cubs: Craig Counsell (2nd season)