San Francisco Giants vs Philadelphia Phillies Prediction, Preview and Odds - 04/16/2025

Game Time: 6:45 pm ET, Wednesday, April 16, 2025

Venue:  Citizens Bank Park, Philadelphia, PA 

Where to Watch:  NBCSP

DraftKings:  Moneyline odds:  Giants +110, Phillies -130; Over/Under:  7.5 runs

Bet365:  Moneyline odds:  Giants +110, Phillies -130; Over/Under:  7.5 runs

BetMGM:  Moneyline odds:  Giants +110, Phillies -130; Over/Under:  7.5 runs

San Francisco Giants:  12-4 (2nd place, NL West)

Philadelphia Phillies:  9-7 (2nd place, NL East)

Do not miss out on our expert handicapper analysis! Will Rogers is on a HOT STREAK in the MLB on an 8-2 MLB RUN for +$5,300 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

San Francisco Giants:  7-3 last 10

Philadelphia Phillies:  4-6 last 10

The Giants are entering this series off a win and won their 3-game series against the New York Yankees 2-1 in their last series. They enter this game with a 12-4 record overall and have a road record of 8-2. This is the 3rd game of a 4-game series with the Phillies on Wednesday with the 2nd game still to be played on Tuesday. The Giants won the series opener on Monday. Their offense ranks 10th in the MLB with a .725 OPS. Justin Verlander is their starting pitcher on Tuesday while Robbie Ray is making his start in this game on Wednesday. He is 3-0 with a 2.93 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 ER, 0 HR, and 4 BB with 7 Ks on 2 hits through 4 IP against the New York Yankees.

The Phillies are entering this series off a loss and lost their 3-game series against the St Louis Cardinals 2-1 in their last series. They enter this game with a 9-7 record overall and have a home record of 5-2. This is the 3rd game of a 4-game series with the Giants on Wednesday with the 2nd game still to be played on Tuesday. The Giants won the 1st game of this series on Monday. Their offense ranks 15th in the MLB with a .699 OPS. Jesús Luzardo is their starting pitcher on Tuesday while Aaron Nola is making his start in this game on Wednesday. He is 0-3 with a 5.51 ERA this season. His team lost their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 0 homers, and 4 BB with 7 strikeouts on 5 hits through 5 innings played against the St Louis Cardinals.

The current betting odds have the Giants listed as a slight underdog in this game according to Draftkings Sportsbook. The Giants have looked really good in their games this season with their 12-4 record overall which has them right near the top of their division with one of the best records in the entire MLB. They have also been a great road team so far with their 8-2 road record this season. Meanwhile, the Phillies have looked good in their games this season with their 9-7 record overall which has them right near the top of their division with a good start to the season. They have looked good in their own ballpark too with their 5-2 home record this season. They have been starting to cool off after a really hot start to the season though. Their offense hasn't been as good as lately and they are only 4-6 in their last 10 games while the Giants are 7-3. The Giants also took the series opener of this series already, and their pitching has been much better. They have Ray going in this one and he has been great in all of his starts this season. His team has won all 3 games he pitched in and he is coming off another good start, only giving up 1 earned run. Nola is up for the Phillies here, but he has had a really rocky start to the season. He only gave up 2 earned runs in his last start as he was better in that one, but he has a 5.51 ERA this season and his team has lost all 3 games he started in. The Giants are hot right now with better pitching while the Phillies have been cooling off lately. The best way to place a bet here is on the Giants to win this game. 

Giants Phillies Prediction:  Our MLB Pick for Wednesday, April 16, 2025 (6:45 pm ET start time) is Giants 6 Phillies 3.

Don't miss our champion handicappers free picks, best bets, and expert baseball picks today.  And if you enjoyed this San Francisco Giants Philadelphia Phillies prediction, be sure to drop by every day for our daily MLB projections and previews.

San Francisco Giants: 30-35 (-10.3 units) on the moneyline against NL East opponents. 171-168 (-11.9 units) on the moneyline in all games. 75-71 (-10 units) on the moneyline vs. a team with a poor bullpen whose ERA is 4.20 or worse. 34-26 UNDER against NL East opponents.

Philadelphia Phillies: 48-31 (+8.5 units) on the moneyline against NL West opponents. 115-63 (+20 units) on the moneyline in home games. 103-50 (+19.3 units) on the moneyline as a home favorite of -110 or higher. 26-15 UNDER vs. a team with a good bullpen whose ERA is 3.45 or better.

San Francisco Giants:  T. Murphy (C) Sixty Day IL - Back. J. Encarnacion (RF) Ten Day IL - Finger.

Philadelphia Phillies:  W. Wilson (LF) Ten Day IL - Oblique. R. Suarez (SP) Fifteen Day IL - Back.

“We’ve just been resilient. We don’t give up. I think that’s the mentality we have right now. We feel like we can come back from any deficit. That’s a great mentality to have. That puts a lot of confidence on the pitchers and obviously the whole team.” - Willy Adames after their win against the Phillies in their game on Monday.

"He's thinking about it quite a bit right now and everybody goes through it at some point. I just thought maybe give him a day or two off and just let him watch for a minute. I think he's really thinking about (his lack of offense). He really feels like he's letting his teammates down. He's putting a lot of pressure on himself to do well. When you get to that point I think it's time just to relax for a minute." - Rob Thomson on benching Brandon Marsh.

Mike Yastrzemski (L) RF

Willy Adames (R) SS

Jung Hoo Lee (L) CF

Matt Chapman (R) 3B

Heliot Ramos (R) LF

LaMonte Wade Jr. (L) 1B

Wilmer Flores (R) DH

Patrick Bailey (S) C

Tyler Fitzgerald (R) 2B

Bryson Stott (L) 2B

Trea Turner (R) SS

Bryce Harper (L) 1B

Kyle Schwarber (L) DH

Nick Castellanos (R) RF

J.T. Realmuto (R) C

Max Kepler (L) LF

Alec Bohm (R) 3B

Johan Rojas (R) CF

Batting Average:  Jung Hoo Lee (.322)

Hits:  Jung Hoo Lee (19)

Home Runs:  Wilmer Flores (6)

RBI:  Wilmer Flores (20)

Stolen Bases:  Tyler Fitzgerald (4)

Wins:  Robbie Ray (3)

Saves:  Ryan Walker (4)

ERA:  Hayden Birdsong (0.00)

Batting Average:  Edmundo Sosa (.444)

Hits:  Nick Castellanos (18)

Home Runs:  Kyle Schwarber (6)

RBI:  Kyle Schwarber (12)

Stolen Bases:  Trea Turner (4)

Wins:  Jesús Luzardo (2)

Saves:  José Alvarado (3)

ERA:  José Alvarado (1.23)

Managers:

San Francisco Giants: Bob Melvin (2nd season)

Philadelphia Phillies: Rob Thomson (4th season)