San Diego Padres vs Milwaukee Brewers Prediction, Preview and Odds - 06/07/2025

Game Time: 7:35 pm ET, Saturday, June 7, 2025

Venue:  American Family Field, Milwaukee, WI 

Where to Watch:  FOX

DraftKings:  Moneyline odds:  Padres -105, Brewers -115; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Padres -105, Brewers -115; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Padres -105, Brewers -115; Over/Under:  8.5 runs

San Diego Padres:  35-26 (2nd place, NL West)

Milwaukee Brewers:  34-29 (3rd place, NL Central)

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San Diego Padres:  6-4 last 10

Milwaukee Brewers:  9-1 last 10

The Padres are entering this series off a loss and split their 4-game series against the San Francisco Giants 2-2 in their last series. They enter this game with a 35-26 record overall and have a road record of 15-16. This is the 2nd game of a 3-game series with the Brewers on Saturday with the series opener still to be played on Friday. Their offense ranks 19th in the MLB with a .694 OPS. Randy Vásquez is their starting pitcher on Friday while Stephen Kolek is making his start in this game on Saturday. He is 3-1 with a 3.47 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 0 ER, 0 HR, and 2 BB with 3 Ks on 3 hits through 5.2 IP against the San Francisco Giants.

The Brewers are entering this series off a win and won their 3-game series against the Cincinnati Reds 2-1 in their last series. They enter this game with a 34-29 record overall and have a home record of 18-10. This is the 2nd game of a 3-game series with the Padres on Saturday with the 1st game of this series still to be played on Friday. Their offense ranks 23rd in the MLB with a .683 OPS. Rookie pitcher Chad Patrick is their starting pitcher on Friday while Jose Quintana is making his start in this game on Saturday. He is 4-1 with a 2.77 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 0 homers, and 4 BB with 3 strikeouts on 4 hits through 5 innings played against the Philadelphia Phillies.

The current betting odds have the Brewers listed as a slight favorite in this game according to Draftkings Sportsbook. The Brewers have looked good in their games this season with their 34-29 record overall which has them right in the middle of the NL Central. They have also looked great in their own ballpark with their 18-10 home record this year. Meanwhile, the Padres have looked really good in their games this season with their 35-26 record overall which has them right near the top of the NL West and right in the division race. They haven't been a great road team this year though with their 15-16 road record. The Padres have looked good lately as they are 6-4 in their last 10 games, but the Brewers have been rolling as they are 9-1 in their last 10 games and this is a pitching matchup that they can definitely take advantage of. The Brewers haven't had a great offense this season, but they have looked a lot better lately with the runs they have been putting up. The Padres don't have a very experienced starter in this one either. Kolek is on the mound for the Padres and he is 3-1 with a 3.47 ERA. He gave up no runs in his last start and the team has won 2 games in a row with him starting, but he is still a young starter in the league and the Padres haven't been at their best in road games. The Brewers will find ways to put up runs in this game and they do have a solid starter on the mound to back them up. Quintana is starting for the Brewers and he is 4-1 with a 2.77 ERA this year. He gave up 2 earned runs in his last start and he hasn't been giving up many runs in any of his starts all year. The Brewers are the hotter team right now and they can edge out the Padres in this game at home. The best way to place a bet here is on the Brewers to win this game. 

Padres Brewers Prediction:  Our MLB Pick for Saturday, June 7, 2025 (7:35 pm ET start time) is Brewers 3 Padres 1.

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San Diego Padres: 41-35 (-6.4 units) on the moneyline against NL Central opponents. 70-79 (-13 units) on the moneyline when the money line is +125 to -125. 14-22 (-8.2 units) on the moneyline vs. an NL starting pitcher whose ERA is 3.20 or better. 20-14 OVER on the road against NL Central opponents. 

Milwaukee Brewers: 219-172 (+29.1 units) on the moneyline in all games. 114-80 (+10.3 units) on the moneyline in home games. 105-66 (+23.8 units) on the moneyline when the money line is -100 to -150. 20-13 OVER at home against NL West opponents. 

San Diego Padres:  L. Arraez (1B) Day To Day - Knee. X. Bogaerts (SS) Day To Day - Shoulder. M. King (SP) Fifteen Day IL - Shoulder. J. Heyward (LF) Ten Day IL - Oblique. M. McCoy (SS) Ten Day IL - Finger. L. Gillaspie (RP) Fifteen Day IL - Oblique. B. Hoeing (RP) Sixty Day IL - Shoulder. J. Brito (RP) Sixty Day IL - Forearm. Y. Darvish (SP) Fifteen Day IL - Elbow. J. Musgrove (SP) Sixty Day IL - Elbow.

Milwaukee Brewers:  N. Cortes (SP) Sixty Day IL - Elbow. C. Thomas (SP) Sixty Day IL - Elbow. B. Woodruff (SP) Fifteen Day IL - Shoulder. G. Mitchell (CF) Ten Day IL - Oblique. B. Perkins (CF) Sixty Day IL - Shin. R. Gasser (SP) Sixty Day IL - Elbow.

“He’s got an approach matching that beautiful swing. Manny’s clearly in a good place.” - Mike Shildt after his team’s loss against the Giants in their game on Thursday.

“It’s kind of been fun, us two taking games and doing our jobs and winning some games. It’s been cool to do what I came here to do, which is give the bullpen guys a rest. If we’re able to do that, it’s a win.” - Quinn Priester after their win against the Reds in their game on Wednesday.

Fernando Tatis Jr. (R) RF

Luis Arraez (L) 1B

Manny Machado (R) 3B

Jackson Merrill (L) CF

Gavin Sheets (L) DH

Jose Iglesias (R) SS

Jake Cronenworth (L) 2B

Brandon Lockridge (R) LF

Martín Maldonado (R) C

Andruw Monasterio (R) 3B

Jackson Chourio (R) CF

Christian Yelich (L) DH

Rhys Hoskins (R) 1B

Daz Cameron (R) LF

Sal Frelick (L) RF

Joey Ortiz (R) SS

Eric Haase (R) C

Brice Turang (L) 2B

Batting Average:  Manny Machado (.317)

Hits:  Manny Machado (72)

Home Runs:  Fernando Tatis (13)

RBI:  Gavin Sheets (38)

Stolen Bases:  Fernando Tatis (12)

Wins:  Nick Pivetta (6)

Saves:  Robert Suarez (19)

ERA:  Bradgley Rodriguez (0.00)

Batting Average:  Sal Frelick (.291)

Hits:  Jackson Chourio (70)

Home Runs:  Christian Yelich (13)

RBI:  Christian Yelich (41)

Stolen Bases:  Brice Turang (14)

Wins:  Freddy Peralta (5)

Saves:  Trevor Megill (12)

ERA:  Rob Zastryzny (0.00)

Managers:

San Diego Padres: Mike Shildt (2nd season)

Milwaukee Brewers: Pat Murphy (2nd season)