San Diego Padres vs Milwaukee Brewers Prediction, Preview and Odds - 06/06/2025

Game Time: 8:10 pm ET, Friday, June 6, 2025

Venue:  American Family Field, Milwaukee, WI 

Where to Watch:  FDSWI

DraftKings:  Moneyline odds:  Padres +124, Brewers -148; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Padres +125, Brewers -150; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Padres +125, Brewers -150; Over/Under:  8.5 runs

San Diego Padres:  35-25 (2nd place, NL West)

Milwaukee Brewers:  34-29 (3rd place, NL Central)

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San Diego Padres:  7-3 last 10

Milwaukee Brewers:  9-1 last 10

The Padres won their 3-game series against the Pittsburgh Pirates 2-1. They enter this game with a 35-25 record overall and have a road record of 15-15. This is the series opener of a 3-game series with the Brewers on Friday with the series finale of their series against the San Francisco Giants still to be played on Thursday. The Padres won the series opener of that series on Monday, won the 2nd game on Tuesday, and lost the 3rd game on Wednesday. Their offense ranks 19th in the MLB with a .696 OPS. Dylan Cease is their starting pitcher on Thursday while Randy Vásquez is making his start in this game on Friday. He is 3-4 with a 3.99 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 4 ER, 2 HR, and 3 BB with 3 Ks on 6 hits through 3.1 IP against the Pittsburgh Pirates.

The Brewers are entering this series off a win and won their 3-game series against the Cincinnati Reds 2-1 in their last series. They enter this game with a 34-29 record overall and have a home record of 18-10. This is the 1st game of a 3-game series with the Padres on Friday and they have Thursday off as a day of rest. Their offense ranks 24th in the MLB with a .683 OPS. DL Hall was their starting pitcher on Wednesday while rookie pitcher Chad Patrick is making his start in this game on Friday. He is 3-4 with a 2.97 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 1 homer, and 0 BB with 6 strikeouts on 5 hits through 6 innings played against the Philadelphia Phillies.

The current betting odds have the Brewers listed as a favorite in this game according to Draftkings Sportsbook. The Brewers have looked good in their games this season with their 34-29 record overall which has them right in the middle of the NL Central. They have also looked great in their own ballpark with their 18-10 home record this year. Meanwhile, the Padres have looked really good in their games this season with their 35-25 record overall which has them right near the top of the NL West and right in the division race. They haven't been a great road team this year though with their 15-15 road record. Both of these teams have been hot lately, but the Brewers have been the hotter team as they are 9-1 in their last 10 games while the Padres are only 7-3 and haven't looked nearly as good in their road games all year. The Brewers are going with Patrick in this one and this is only his 1st MLB season as a starter, but he has looked good so far. He is 3-4 with a 2.97 ERA and hasn't been giving up many runs all year. He is coming off a good start in which he gave up 2 earned runs, and the team has been finding success with him now, winning their last 2 games with him starting. Vasquez is on the mound for the Padres here and he hasn't looked great lately. He is 3-4 with a 3.99 ERA and the team has won 2 games in a row now with him starting, but he did give up 4 earned runs in his last start and that Padres offense hasn't been as good in their road games. The best way to place a bet here is on the Brewers to win this game. 

Padres Brewers Prediction:  Our MLB Pick for Friday, June 6, 2025 (8:10 pm ET start time) is Brewers 6 Padres 1.

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San Diego Padres: 41-35 (-6.4 units) on the moneyline against NL Central opponents. 147-130 (-12 units) on the moneyline against right-handed starters. 39-46 (-10.1 units) on the moneyline vs. an NL starting pitcher whose WHIP is 1.250 or better. 20-14 OVER on the road against NL Central opponents. 

Milwaukee Brewers: 219-172 (+29.1 units) on the moneyline in all games. 114-80 (+10.3 units) on the moneyline in home games. 105-66 (+23.8 units) on the moneyline when the money line is -100 to -150. 14-6 OVER after a win by 8 runs or more.

San Diego Padres:  X. Bogaerts (SS) Day To Day - Shoulder. M. King (SP) Fifteen Day IL - Shoulder. J. Heyward (LF) Ten Day IL - Oblique. M. McCoy (SS) Ten Day IL - Finger. L. Gillaspie (RP) Fifteen Day IL - Oblique. B. Hoeing (RP) Sixty Day IL - Shoulder. J. Brito (RP) Sixty Day IL - Forearm. Y. Darvish (SP) Fifteen Day IL - Elbow. J. Musgrove (SP) Sixty Day IL - Elbow.

Milwaukee Brewers:  N. Cortes (SP) Sixty Day IL - Elbow. C. Thomas (SP) Sixty Day IL - Elbow. B. Woodruff (SP) Fifteen Day IL - Shoulder. G. Mitchell (CF) Ten Day IL - Oblique. B. Perkins (CF) Sixty Day IL - Shin. R. Gasser (SP) Sixty Day IL - Elbow.

“Shoulder was sore -- left shoulder. I haven’t heard anything more. Hopefully we’ll hear something favorable.” - Mike Shildt on the injury to Xander Bogaerts after his team’s loss against the Giants in their game on Wednesday.

“It’s kind of been fun, us two taking games and doing our jobs and winning some games. It’s been cool to do what I came here to do, which is give the bullpen guys a rest. If we’re able to do that, it’s a win.” - Quinn Priester after their win against the Reds in their game on Wednesday.

Fernando Tatis Jr. (R) RF

Luis Arraez (L) DH

Manny Machado (R) 3B

Jackson Merrill (L) CF

Gavin Sheets (L) 1B

Xander Bogaerts (R) SS

Jake Cronenworth (L) 2B

Brandon Lockridge (R) LF

Elias Díaz (R) C

Andruw Monasterio (R) 3B

Jackson Chourio (R) CF

Christian Yelich (L) DH

Rhys Hoskins (R) 1B

Daz Cameron (R) LF

Sal Frelick (L) RF

Joey Ortiz (R) SS

Eric Haase (R) C

Brice Turang (L) 2B

Batting Average:  Jackson Merrill (.319)

Hits:  Manny Machado (70)

Home Runs:  Fernando Tatis (13)

RBI:  Gavin Sheets (38)

Stolen Bases:  Fernando Tatis (12)

Wins:  Nick Pivetta (6)

Saves:  Robert Suarez (19)

ERA:  Bradgley Rodriguez (0.00)

Batting Average:  Sal Frelick (.291)

Hits:  Jackson Chourio (70)

Home Runs:  Christian Yelich (13)

RBI:  Christian Yelich (41)

Stolen Bases:  Brice Turang (14)

Wins:  Freddy Peralta (5)

Saves:  Trevor Megill (12)

ERA:  Rob Zastryzny (0.00)

Managers:

San Diego Padres: Mike Shildt (2nd season)

Milwaukee Brewers: Pat Murphy (2nd season)