Milwaukee Brewers vs Minnesota Twins Prediction, Preview and Odds - 06/21/2025

Game Time: 2:10 pm ET, Saturday, June 21, 2025

Venue:  Target Field, Minneapolis, MN

Where to Watch:  TWINS.tv

DraftKings:  Moneyline odds:  Brewers +120, Twins -140; Over/Under:  9.5 runs

Bet365:  Moneyline odds:  Brewers +120, Twins -140; Over/Under:  9.5 runs

BetMGM:  Moneyline odds:  Brewers +120, Twins -140; Over/Under:  9.5 runs

Milwaukee Brewers:  40-35 (2nd place, NL Central)

Minnesota Twins:  37-37 (3rd place, AL Central)

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Milwaukee Brewers:  5-5 last 10

Minnesota Twins:  3-7 last 10

The Brewers are entering this series off a win and split their 2-game series against the Chicago Cubs 1-1 in their last series. They enter this game with a 40-35 record overall and have a road record of 17-20. This is the 2nd game of a 3-game series with the Twins on Saturday with the series opener still to be played on Friday. Their offense ranks 24th in the MLB with a .683 OPS. Rookie pitcher Jacob Misiorowski is their starting pitcher on Friday while Jose Quintana is making his start in this game on Saturday. He is 4-2 with a 3.35 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 5 ER, 1 HR, and 3 BB with 4 SO on 8 hits through 4.1 IP against the St Louis Cardinals.

The Twins are entering this series off a win and lost their 3-game series against the Cincinnati Reds 2-1 in their last series. They enter this game with a 37-37 record overall and have a home record of 20-12. This is the 2nd game of a 3-game series with the Brewers on Saturday with the 1st game of this series still to be played on Friday. Their offense ranks 16th in the MLB with a .710 OPS. Joe Ryan is their starting pitcher on Friday while Simeon Woods Richardson is making his start in this game on Saturday. He is 2-3 with a 5.13 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 1 walk with 4 strikeouts on 1 hit through 5 innings pitched against the Houston Astros.

The current betting odds have the Brewers listed as an underdog in this game according to Draftkings Sportsbook. The Twins haven't looked great in their games this season with their 37-37 record overall, but that record has them right in the middle of the AL Central and in the Wild Card race. They have also looked a lot better in their own ballpark this year with their 20-12 home record. Meanwhile, the Brewers have looked good in their games this season with their 40-35 record overall which has them right near the top of the NL Central. They haven't been a great road team though with their 17-20 road record this season. The Brewers haven't looked great lately as they are only 5-5 in their last 10 games, but they have still looked a lot better than the Twins who are 3-7 in their last 10 games. The Brewers also have the better pitching matchup in this one and they can take advantage of that. The Brewers are going with Quintana in this one and he has looked good this season. He is 4-2 with a 3.35 ERA and the team has won 2 of the last 3 games he started in too. He did give up 5 earned runs in his last start, but that hasn't been a common theme for him this year and he will be looking to bounce back with a better start. The Twins are going with Woods Richardson in this one and he hasn't looked good in his starts this year. He is 2-3 with a 5.13 ERA and has been giving up quite a few runs in his starts. He is coming off a good start in his last one in which he didn't give up any runs, but that hasn't been a common theme for him this year and the team has still lost 2 games in a row with him starting. The best way to place a bet here is on the Brewers to win this game. 

Brewers Twins Prediction:  Our MLB Pick for Saturday, June 21, 2025 (2:10 pm ET start time) is Brewers 6 Twins 3.

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Milwaukee Brewers: 30-16 (+13.3 units) on the moneyline against AL Central opponents. 83-85 (+18.3 units) on the moneyline as an underdog of +100 or higher. 106-93 (+19 units) on the moneyline in road games. 15-7 OVER on the road against AL Central opponents. 

Minnesota Twins: 18-23 (-11.3 units) on the moneyline against NL Central opponents. 112-86 (-11.2 units) on the moneyline in home games. 158-115 (-11.2 units) on the moneyline as a favorite of -110 or higher. 31-24 OVER when the total is 9 to 9.5.

Milwaukee Brewers:  B. Woodruff (SP) Sixty Day IL - Shoulder. N. Cortes (SP) Sixty Day IL - Elbow. C. Thomas (SP) Sixty Day IL - Elbow. G. Mitchell (CF) Ten Day IL - Oblique. B. Perkins (CF) Sixty Day IL - Shin. R. Gasser (SP) Sixty Day IL - Elbow.

Minnesota Twins:  R. Lewis (3B) Ten Day IL - Hamstring. P. Lopez (SP) Sixty Day IL - Shoulder. Z. Matthews (SP) Fifteen Day IL - Shoulder. L. Keaschall (2B) Sixty Day IL - Forearm.

“He's getting comfortable, and he's getting confident. He knows what he has to do, and he's a tenacious competitor. No situation's going to be too big for him. He's worked too hard to get here, so he's not going to back down from any situation.” - Pat Murphy on Caleb Durbin after his team’s win against the Cubs in their game on Thursday. 

“He's been in that really good, relaxed place. You might call it 'the zone.' He's playing great. Seeing the ball good. Had another good day at the plate, swinging at good pitches. Really attacking and barreling them up. Another incredible effort.” - Rocco Baldelli on Byron Buxton after his team’s win against the Reds in their game on Thursday.

Sal Frelick (L) RF

Jackson Chourio (R) CF

Christian Yelich (L) DH

William Contreras (R) C

Brice Turang (L) 2B

Rhys Hoskins (R) 1B

Isaac Collins (S) LF

Caleb Durbin (R) 3B

Joey Ortiz (R) SS

Byron Buxton (R) CF

Matt Wallner (L) RF

Willi Castro (S) LF

Trevor Larnach (L) DH

Carlos Correa (R) SS

Ty France (R) 1B

Brooks Lee (S) 3B

Ryan Jeffers (R) C

Kody Clemens (L) 2B

Batting Average:  Sal Frelick (.287)

Hits:  Jackson Chourio (83)

Home Runs:  Christian Yelich (14)

RBI:  Christian Yelich (44)

Stolen Bases:  Brice Turang (16)

Wins:  Freddy Peralta (7)

Saves:  Trevor Megill (16)

ERA:  Jacob Misiorowski (0.00)

Batting Average:  Luke Keaschall (.368)

Hits:  Ty France (70)

Home Runs:  Byron Buxton (15)

RBI:  Byron Buxton (45)

Stolen Bases:  Byron Buxton (12)

Wins:  Joe Ryan (7)

Saves:  Jhoan Duran (10)

ERA:  Danny Coulombe (0.47)

Managers:

Milwaukee Brewers: Pat Murphy (2nd season)

Minnesota Twins: Rocco Baldelli (7th season)