Kansas City Royals vs St Louis Cardinals Prediction, Preview and Odds - 06/03/2025

Game Time: 7:45 pm ET, Tuesday, June 3, 2025

Venue:  Busch Stadium, St. Louis, MO

Where to Watch:  FDSMW

DraftKings:  Moneyline odds:  Royals +120, Cardinals -142; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Royals +120, Cardinals -140; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Royals +125, Cardinals -150; Over/Under:  8.5 runs

Kansas City Royals:  31-29 (4th place, AL Central)

St Louis Cardinals:  33-26 (2nd place, NL Central)

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Kansas City Royals:  4-6 last 10

St Louis Cardinals:  6-4 last 10

The Royals are entering this series off a loss and lost their 3-game series against the Detroit Tigers 2-1 in their last series. They enter this game with a 31-29 record overall and have a road record of 12-16. This is the series opener of a 3-game series with the Cardinals on Tuesday and they have Monday off as a day of rest. Their offense ranks 26th in the MLB with a .659 OPS. Kris Bubic was their starting pitcher on Sunday while Michael Lorenzen is making his start in this game on Tuesday. He is 3-6 with a 4.33 ERA this season. His team lost their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 6 ER, 1 HR, and 3 BB with 2 Ks on 11 hits through 5 IP against the Cincinnati Reds.

The Cardinals are entering this series off a loss and lost their 3-game series against the Texas Rangers 2-1 in their last series. They enter this game with a 33-26 record overall and have a home record of 19-8. This is the 1st game of a 3-game series with the Royals on Tuesday and they have Monday off as a day of rest. Their offense ranks 11th in the MLB with a .722 OPS. Erick Fedde was their starting pitcher on Sunday while Andre Pallante is making his start in this game on Tuesday. He is 4-3 with a 4.23 ERA this season. His team won 4 of their last 5 games this season with him making an appearance. In his last MLB regular season start, he allowed 3 earned runs, 1 homer, and 3 BB with 7 strikeouts on 6 hits through 5.2 innings played against the Baltimore Orioles.

The current betting odds have the Cardinals listed as a favorite in this game according to Draftkings Sportsbook. The Cardinals have looked good in their games this season with their 33-26 record overall which has them right near the top of the NL Central. They have also looked a lot better in their own ballpark this year with their 19-8 home record. Meanwhile, the Royals have looked good in their games this season with their 31-29 record overall, but that record also has them near the bottom of the AL Central in a competitive division. They haven't been a good road team either with their 12-16 road record this season. The Royals don't have a great offense this year either and they haven't really been that hot lately, going 4-6 in their last 10 games and losing their last series too. The Cardinals have been hot though as they are 6-4 in their last 10 games and even though they lost their last series too, they have looked a lot better in their home games. Pallante is on the mound for them and he is 4-3 with a 4.23 ERA this season. He hasn't been lights out this season and did give up 3 earned runs in his last start, but he hasn't been giving up a ton of runs in most of his starts this season and the team has still won 4 of their last 5 games with him starting too. Lorenzen is on the mound for the Royals and he is 3-6 with a 4.33 ERA this season. He hasn't looked great lately as he gave up 6 earned runs in his last start and the team has lost 3 games in a row with him starting too. The Royals haven't been hitting well in their games lately so this is a great situation for the Cardinals to bounce back at home against a struggling opponent. The best way to place a bet here is on the Cardinals to win this game. 

Royals Cardinals Prediction:  Our MLB Pick for Tuesday, June 3, 2025 (7:45 pm ET start time) is Cardinals 4 Royals 3.

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Kansas City Royals: 32-30 (+9.3 units) on the moneyline after 3 consecutive games versus a division rival. 67-62 (+11.8 units) on the moneyline after 3 or more consecutive home games. 50-29 (+24 units) on the moneyline vs. poor power teams - averaging 0.9 or less HR's/game. 51-28 UNDER vs. poor power teams - averaging 0.9 or less HR's/game.

St Louis Cardinals: 186-196 (-21.6 units) on the moneyline in all games. 98-91 (-15.4 units) on the moneyline in home games. 135-142 (-13.1 units) on the moneyline against right-handed starters. 6-2 UNDER after 6 consecutive games versus interleague opponents.

Kansas City Royals:  M. Garcia (3B) Day To Day - Thumb. L. Erceg (RP) Fifteen Day IL - Back. C. Ragans (SP) Fifteen Day IL - Groin. A. Marsh (SP) Sixty Day IL - Shoulder. J. McArthur (RP) Sixty Day IL - Elbow. S. Long (RP) Fifteen Day IL - Elbow. H. Harvey (RP) Fifteen Day IL - Shoulder. K. Wright (SP) Fifteen Day IL - Shoulder.

St Louis Cardinals:  J. Walker (RF) Ten Day IL - Wrist. Z. Thompson (RP) Sixty Day IL - Lat.

“You feel like you’re leaving a win out there, for sure.” - Matt Quatraro after his team’s loss against the Tigers in their game on Sunday.

“We just weren’t good enough to win a Major League Baseball game today. Just some non-plays is what it came down to.” - Oliver Marmol after his team’s loss against the Rangers in their game on Sunday.

Jonathan India (R) DH

Bobby Witt Jr. (R) SS

Vinnie Pasquantino (L) 1B

Salvador Perez (R) C

Drew Waters (S) LF

John Rave (L) RF

Nick Loftin (R) 3B

Michael Massey (L) 2B

Kyle Isbel (L) CF

Lars Nootbaar (L) LF

Masyn Winn (R) SS

Brendan Donovan (L) 2B

Willson Contreras (R) 1B

Iván Herrera (R) DH

Nolan Arenado (R) 3B

Alec Burleson (L) RF

Pedro Pagés (R) C

Victor Scott II (L) CF

Batting Average:  Luke Maile (.375)

Hits:  Maikel Garcia (66)

Home Runs:  Vinnie Pasquantino (8)

RBI:  Vinnie Pasquantino (31)

Stolen Bases:  Bobby Witt (20)

Wins:  Kris Bubic (5)

Saves:  Carlos Estévez (16)

ERA:  Hunter Harvey (0.00)

Batting Average:  Thomas Saggese (.341)

Hits:  Brendan Donovan (70)

Home Runs:  Lars Nootbaar (8)

RBI:  Willson Contreras (31)

Stolen Bases:  Victor Scott (16)

Wins:  Sonny Gray (6)

Saves:  Ryan Helsley (13)

ERA:  Michael McGreevy (0.00)

Managers:

Kansas City Royals: Matt Quatraro (3rd season)

St Louis Cardinals: Oliver Marmol (4th season)