Houston Astros vs Cleveland Guardians Prediction, Preview and Odds - 06/07/2025

Game Time: 4:10 pm ET, Saturday, June 7, 2025

Venue:  Progressive Field, Cleveland, OH

Where to Watch:  CLEGUARDIANS.tv

DraftKings:  Moneyline odds:  Astros -144, Guardians +118; Over/Under:  7.5 runs

Bet365:  Moneyline odds:  Astros -145, Guardians +120; Over/Under:  7.5 runs

BetMGM:  Moneyline odds:  Astros -145, Guardians +120; Over/Under:  7.5 runs

Houston Astros:  34-28 (1st place, AL West)

Cleveland Guardians:  33-28 (3rd place, AL Central)

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Houston Astros:  7-3 last 10

Cleveland Guardians:  4-6 last 10

The Astros are entering this series off a win and won their 3-game series against the Pittsburgh Pirates 2-1 in their last series. They enter this game with a 34-28 record overall and have a road record of 12-16. This is the 2nd game of a 3-game series with the Guardians on Saturday with the series opener still to be played on Friday. Their offense ranks 14th in the MLB with a .708 OPS. Rookie pitcher Colton Gordon is their starting pitcher on Friday while Hunter Brown is making his start in this game on Saturday. He is 8-3 with a 1.83 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 0 ER, 0 HR, and 4 BB with 5 Ks on 1 hit through 6 IP against the Tampa Bay Rays.

The Guardians are entering this series off a loss and lost their 3-game series against the New York Yankees 2-1 in their last series. They enter this game with a 33-28 record overall and have a home record of 17-11. This is the 2nd game of a 3-game series with the Astros on Saturday with the 1st game of this series still to be played on Friday. Their offense ranks 24th in the MLB with a .682 OPS. Logan Allen is their starting pitcher on Friday while Gavin Williams is making his start in this game on Saturday. He is 5-3 with a 3.79 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 2 BB with 6 strikeouts on 1 hit through 6.2 innings played against the Los Angeles Angels.

The current betting odds have the Astros listed as a favorite in this game according to Draftkings Sportsbook. The Guardians have looked good in their games this season with their 33-28 record overall which has them right in the middle of the AL Central in a competitive division. They have looked good in their own ballpark too with their 17-11 home record this year. Meanwhile, the Astros have looked good in their games this season with their 34-28 record overall which has them right at the top of the AL West. They haven't been a great road team though with their 12-16 road record this season. The Astros have been starting to get hot lately though, going 7-3 in their last 10 games while the Guardians are only 4-6. The Astros also have the better pitching matchup in this one and can take advantage of that now that they are getting hot. Brown is on the mound for the Astros in this one and he has been lights out this season. He is 8-3 with a 1.83 ERA and has pretty much been their ace this year. He gave up no runs in his last start which has been a common theme for him this year, and the team has won 2 games in a row with him starting too. The Guardians are going with Williams in this one and he hasn't looked bad this year, but he definitely hasn't looked as good as Brown. Williams is 5-3 with a 3.79 ERA and his team has won 2 of the last 3 games he started in. He is also coming off a great start in which he gave up no runs, but the Guardians don't have a great offense to offer him support and they haven't been putting up a ton of runs lately either. The best way to place a bet here is on the Astros to win this game. 

Astros Guardians Prediction:  Our MLB Pick for Saturday, June 7, 2025 (4:10 pm ET start time) is Astros 4 Guardians 2.

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Houston Astros: 43-38 (-12.5 units) on the moneyline against AL Central opponents. 218-178 (-12.7 units) on the moneyline in all games. 86-94 (-31.1 units) on the moneyline when the money line is -100 to -150. 86-57 UNDER vs. AL teams scoring 4.4 or less runs/game on the season.

Cleveland Guardians: 40-28 (+7.9 units) on the moneyline against AL West opponents. 112-82 (+12.4 units) on the moneyline in home games. 136-113 (+10.4 units) on the moneyline vs. an AL team with an on base percentage .330 or worse. 13-5 UNDER as a home underdog of +125 or more. 

Houston Astros:  Z. Dezenzo (RF) Ten Day IL - Hand. R. Blanco (SP) Sixty Day IL - Elbow. C. McCormick (LF) Ten Day IL - Oblique. H. Wesneski (RP) Sixty Day IL - Elbow. Y. Alvarez (LF) Ten Day IL - Hand. S. Arrighetti (SP) Fifteen Day IL - Thumb. L. Garcia (SP) Sixty Day IL - Elbow. C. Javier (SP) Sixty Day IL - Elbow. P. Leon (RF) Ten Day IL - Knee. J. France (SP) Sixty Day IL - Shoulder. T. Trammell (LF) Ten Day IL - Calf.

Cleveland Guardians:  A. Walters (RP) Fifteen Day IL - Lat. L. Thomas (CF) Ten Day IL - Foot. B. Lively (SP) Sixty Day IL - Forearm. W. Brennan (RF) Ten Day IL - Forearm. P. Sewald (RP) Fifteen Day IL - Shoulder. S. Bieber (SP) Sixty Day IL - Elbow. E. Sabrowski (RP) Sixty Day IL - Elbow. T. Stephan (RP) Sixty Day IL - Elbow. J. Means (SP) Sixty Day IL - Elbow. S. Hentges (RP) Sixty Day IL - Shoulder.

“Just to be able to deliver those hits and help us win this game, he’s in [the clubhouse] feeling pretty good about himself. You could see the confidence in the [at-bats], and then he showed the speed factor with the stolen base. He’s an exciting player to watch. He’s been facing pretty good pitching, and he’s handling himself well.” - Joe Espada after his team’s win against the Pirates in their game on Thursday.

“It’s not an easy role at all. It's very, very difficult to be playing as seldom as he is, and then come in and contribute. But you just have to keep yourself ready.” - Stephen Vogt after his team’s loss against the Yankees in their game on Thursday.

Jeremy Peña (R) SS

Isaac Paredes (R) 3B

Jose Altuve (R) DH

Christian Walker (R) 1B

Yainer Diaz (R) C

Jake Meyers (R) CF

Cam Smith (R) RF

Jacob Melton (L) LF

Mauricio Dubón (R) 2B

Steven Kwan (L) LF

Angel Martínez (S) CF

José Ramírez (S) 3B

David Fry (R) DH

Carlos Santana (S) 1B

Gabriel Arias (R) SS

Bo Naylor (L) C

Jhonkensy Noel (R) RF

Will Wilson (R) 2B

Batting Average:  Jeremy Peña (.318)

Hits:  Jeremy Peña (75)

Home Runs:  Isaac Paredes (14)

RBI:  Isaac Paredes (37)

Stolen Bases:  Jeremy Peña (11)

Wins:  Hunter Brown (8)

Saves:  Josh Hader (16)

ERA:  Brandon Walter (0.00)

Batting Average:  José Ramírez (.330)

Hits:  José Ramírez (74)

Home Runs:  José Ramírez (11)

RBI:  José Ramírez (29)

Stolen Bases:  José Ramírez (17)

Wins:  Gavin Williams (5)

Saves:  Emmanuel Clase (13)

ERA:  Hunter Gaddis (1.09)

Managers:

Houston Astros: Joe Espada (2nd season)

Cleveland Guardians: Stephen Vogt (2nd season)