Houston Astros vs Cleveland Guardians Prediction, Preview and Odds - 06/06/2025

Game Time: 7:10 pm ET, Friday, June 6, 2025

Venue:  Progressive Field, Cleveland, OH

Where to Watch:  MLBN Alt, WKYC

DraftKings:  Moneyline odds:  Astros +105, Guardians -125; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Astros +105, Guardians -125; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Astros +105, Guardians -125; Over/Under:  8.5 runs

Houston Astros:  33-28 (1st place, AL West)

Cleveland Guardians:  33-27 (3rd place, AL Central)

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Houston Astros:  7-3 last 10

Cleveland Guardians:  5-5 last 10

The Astros split their 4-game series against the Tampa Bay Rays 2-2. They enter this game with a 33-28 record overall and have a road record of 11-16. This is the series opener of a 3-game series with the Guardians on Friday with the series finale of their series against the Pittsburgh Pirates still to be played on Thursday. The Astros won the series opener of that series on Tuesday and lost the 2nd game on Wednesday. Their offense ranks 14th in the MLB with a .706 OPS. Framber Valdez is their starting pitcher on Thursday while rookie pitcher Colton Gordon is making his start in this game on Friday. He is 0-1 with a 5.95 ERA this season. His team won 3 of their last 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 4 ER, 2 HR, and 1 BB with 6 Ks on 5 hits through 5 IP against the Tampa Bay Rays.

The Guardians won their 3-game series against the Los Angeles Angels 2-1. They enter this game with a 33-27 record overall and have a home record of 17-11. This is the 1st game of a 3-game series with the Astros on Friday with the 3rd game of their series against the New York Yankees still to be played on Thursday. The Guardians lost the 1st game of that series on Tuesday and won the 2nd game on Wednesday. Their offense ranks 22nd in the MLB with a .689 OPS. Slade Cecconi is their starting pitcher on Thursday while Logan Allen is making his start in this game on Friday. He is 3-3 with a 4.22 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 0 BB with 2 strikeouts on 0 hits through 1 inning played against the Los Angeles Angels.

The current betting odds have the Guardians listed as a slight favorite in this game according to Draftkings Sportsbook. The Guardians have looked good in their games this season with their 33-27 record overall which has them right in the middle of the AL Central in a competitive division. They have looked good in their own ballpark too with their 17-11 home record this year. Meanwhile, the Astros have looked good in their games this season with their 33-28 record overall which has them right at the top of the AL West. They haven't been a great road team though with their 11-16 road record this season. The Astros have been the hotter team lately, but the Guardians have the better pitching matchup in this one and they can take advantage of that in this home game. Allen is on the mound for the Guardians here and he hasn't looked bad this season. He is 3-3 with a 4.22 ERA and he is coming off a great start in which he gave up no runs. He only pitched 1 inning in that start, but he will be looking to go deeper into this start and he does have the better bullpen to help him out too. Gordon is on the mound for the Astros in this one and he has struggled in his 1st MLB season. He is 0-1 with a 5.95 ERA and he gave up 4 earned runs in his last start too. The team has been having success with him this season, but that is bound to regress with the way he has been giving up runs in his few starts. The best way to place a bet here is on the Guardians to win this game. 

Astros Guardians Prediction:  Our MLB Pick for Friday, June 6, 2025 (7:10 pm ET start time) is Guardians 4 Astros 2.

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Houston Astros: 43-38 (-12.5 units) on the moneyline against AL Central opponents. 217-178 (-13.7 units) on the moneyline in all games. 59-47 (-10.3 units) on the moneyline against left-handed starters. 86-57 UNDER vs. AL teams scoring 4.4 or less runs/game on the season.

Cleveland Guardians: 40-28 (+7.9 units) on the moneyline against AL West opponents. 112-82 (+12.4 units) on the moneyline in home games. 136-113 (+10.4 units) on the moneyline vs. an AL team with an on base percentage .330 or worse. 30-17 UNDER vs. a starting pitcher who gives up 1 or more HR's/start.

Houston Astros:  Z. Dezenzo (RF) Ten Day IL - Hand. R. Blanco (SP) Sixty Day IL - Elbow. C. McCormick (LF) Ten Day IL - Oblique. H. Wesneski (RP) Sixty Day IL - Elbow. Y. Alvarez (LF) Ten Day IL - Hand. S. Arrighetti (SP) Fifteen Day IL - Thumb. L. Garcia (SP) Sixty Day IL - Elbow. C. Javier (SP) Sixty Day IL - Elbow. P. Leon (RF) Ten Day IL - Knee. J. France (SP) Sixty Day IL - Shoulder. T. Trammell (LF) Ten Day IL - Calf.

Cleveland Guardians:  A. Walters (RP) Fifteen Day IL - Lat. L. Thomas (CF) Ten Day IL - Foot. B. Lively (SP) Sixty Day IL - Forearm. W. Brennan (RF) Ten Day IL - Forearm. P. Sewald (RP) Fifteen Day IL - Shoulder. S. Bieber (SP) Sixty Day IL - Elbow. E. Sabrowski (RP) Sixty Day IL - Elbow. T. Stephan (RP) Sixty Day IL - Elbow. J. Means (SP) Sixty Day IL - Elbow. S. Hentges (RP) Sixty Day IL - Shoulder.

“I thought we couldn’t get our bats going. There were some pretty decent arms we saw today. They mixed their pitches well, and we couldn’t get any offense going. It was one of those games.” - Joe Espada after his team’s loss against the Pirates in their game on Wednesday.

"It's been a really good few weeks. I don't know all the exacts, but we are continuing to see these guys grow and learn and get better every time out.” - Stephen Vogt after his team’s win against the Yankees in their game on Wednesday.

Jeremy Peña (R) SS

Isaac Paredes (R) 3B

Jose Altuve (R) 2B

Christian Walker (R) 1B

Yainer Diaz (R) C

Victor Caratini (S) DH

Jake Meyers (R) CF

Cam Smith (R) RF

Jacob Melton (L) LF

Steven Kwan (L) LF

Angel Martínez (S) CF

José Ramírez (S) 3B

Carlos Santana (S) DH

Kyle Manzardo (L) 1B

Daniel Schneemann (L) 2B

Gabriel Arias (R) SS

Bo Naylor (L) C

Nolan Jones (L) RF

Batting Average:  Jeremy Peña (.312)

Hits:  Jeremy Peña (72)

Home Runs:  Isaac Paredes (12)

RBI:  Isaac Paredes (34)

Stolen Bases:  Jeremy Peña (10)

Wins:  Hunter Brown (8)

Saves:  Josh Hader (16)

ERA:  Brandon Walter (0.00)

Batting Average:  José Ramírez (.327)

Hits:  José Ramírez (72)

Home Runs:  José Ramírez (11)

RBI:  José Ramírez (29)

Stolen Bases:  José Ramírez (16)

Wins:  Gavin Williams (5)

Saves:  Emmanuel Clase (13)

ERA:  Hunter Gaddis (1.09)

Managers:

Houston Astros: Joe Espada (2nd season)

Cleveland Guardians: Stephen Vogt (2nd season)