Cleveland Guardians vs New York Yankees Prediction, Preview and Odds - 06/05/2025

Game Time: 7:05 pm ET, Thursday, June 5, 2025

Venue:  Yankee Stadium, Bronx, NY

Where to Watch:  MLBN

DraftKings:  Moneyline odds:  Guardians +215, Yankees -265; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Guardians +215, Yankees -265; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Guardians +215, Yankees -265; Over/Under:  8.5 runs

Cleveland Guardians:  32-27 (3rd place, AL Central)

New York Yankees:  37-22 (1st place, AL East)

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Cleveland Guardians:  5-5 last 10

New York Yankees:  7-3 last 10

The Guardians are entering this series off a win and won their 3-game series against the Los Angeles Angels 2-1 in their last series. They enter this game with a 32-27 record overall and have a road record of 15-16. This is the series finale of a 3-game series with the Yankees on Thursday with the 2nd game still to be played on Wednesday. The Guardians lost the series opener on Tuesday. Their offense ranks 23rd in the MLB with a .685 OPS. Luis Ortiz is their starting pitcher on Wednesday while Slade Cecconi is making his start in this game on Thursday. He is 1-1 with a 5.28 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 5 ER, 3 HR, and 3 BB with 3 Ks on 7 hits through 4.1 IP against the Los Angeles Angels.

The Yankees are entering this series off a win and lost their 3-game series against the Los Angeles Dodgers 2-1 in their last series. They enter this game with a 37-22 record overall and have a home record of 19-9. This is the 3rd game of a 3-game series with the Guardians on Thursday with the 2nd game of this series still to be played on Wednesday. The Yankees won the 1st game of this series on Tuesday. Their offense ranks 2nd in the MLB with a .810 OPS. Clarke Schmidt is their starting pitcher on Wednesday while Max Fried is making his start in this game on Thursday. He is 7-1 with a 1.92 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 6 earned runs, 2 homers, and 0 BB with 3 strikeouts on 8 hits through 5 innings played against the Los Angeles Dodgers.

The current betting odds have the Yankees listed as a big favorite in this game according to Draftkings Sportsbook. The Yankees have looked really good in their games this season with their 37-22 record overall which has them at the top of the AL East with one of the best records in the entire MLB. They have also looked great in their own ballpark this year with their 19-9 home record. Meanwhile, the Guardians have looked good in their games this season with their 32-27 record overall which has them right in the middle of the AL Central. They haven't been a great road team this year though with their 15-16 road record. The Yankees have been the hotter team lately as they are 7-3 in their last 10 games while the Guardians are 5-5, but the Yankees also have the better pitching matchup here to take advantage of. Fried is on the mound for the Yankees in this one and he has looked great this season. He is 7-1 with a 1.92 ERA and the team has won 2 of their last 3 games with him starting. He is coming off a bad start in which he gave up 6 earned runs, but that was also on the road against the Dodgers who have the best offense in the MLB. He will be looking to bounce back at home with a better performance and the Guardians do not have a good offense to challenge him with. Cecconi is also on the mound for the Guardians and he hasn't looked great this season. He is 1-1 with a 5.28 ERA and is coming off a start in which he gave up 5 earned runs. This is a really tough matchup for the Guardians when the Yankees have one of the best offenses in the MLB right now. The best way to place a bet here is on the Yankees to win this game. 

Guardians Yankees Prediction:  Our MLB Pick for Thursday, June 5, 2025 (7:05 pm ET start time) is Yankees 7 Guardians 1.

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Cleveland Guardians: 92-105 (-10.2 units) on the moneyline in road games. 76-100 (-5.2 units) on the moneyline as an underdog of +100 or higher. 49-65 (-10.8 units) on the moneyline vs. teams outscoring opp by 0.5 or more runs/game on the season. 22-11 UNDER when playing against a top-level team (Win Pct. > 62%).

New York Yankees: 55-27 (+17.4 units) on the moneyline against AL Central opponents. 95-47 (+5.8 units) on the moneyline as a favorite of -150 or more. 177-132 (+15.7 units) on the moneyline against right-handed starters. 51-30 UNDER against AL Central opponents.

Cleveland Guardians:  A. Walters (RP) Fifteen Day IL - Arm. L. Thomas (CF) Ten Day IL - Foot. B. Lively (SP) Sixty Day IL - Forearm. W. Brennan (RF) Ten Day IL - Forearm. P. Sewald (RP) Fifteen Day IL - Shoulder. S. Bieber (SP) Sixty Day IL - Elbow. E. Sabrowski (RP) Sixty Day IL - Elbow. T. Stephan (RP) Sixty Day IL - Elbow. J. Means (SP) Sixty Day IL - Elbow. S. Hentges (RP) Sixty Day IL - Shoulder.

New York Yankees:  J. Dominguez (LF) Day To Day - Thumb. L. Weaver (RP) Fifteen Day IL - Hamstring. L. Gil (SP) Sixty Day IL - Back. O. Cabrera (3B) Ten Day IL - Ankle. G. Stanton (DH) Sixty Day IL - Elbow. M. Stroman (SP) Fifteen Day IL - Knee. J. Brubaker (SP) Sixty Day IL - Ribs. J. Cousins (RP) Sixty Day IL - Elbow. G. Cole (SP) Sixty Day IL - Elbow.

“Bibee was outstanding. That's as good as we've seen him. Cruising, keeping his pitch count low, getting weak contact, a lot of punchouts tonight. His outing was much better than his line ended up being. Gave up the two homers there at the end, but he was some kind of special tonight.” - Stephen Vogt after his team’s loss against the Yankees in their game on Tuesday.

“These guys make it easy. Offensively, we’re so good. I just know I have to get outs and eventually we’re going to score more than a few runs.” - Carlos Rodón after their win against the Guardians in their game on Tuesday.

Steven Kwan (L) LF

Angel Martínez (S) CF

José Ramírez (S) 3B

David Fry (R) DH

Carlos Santana (S) 1B

Gabriel Arias (R) SS

Will Wilson (R) 2B

Bo Naylor (L) C

Jhonkensy Noel (R) RF

Trent Grisham (L) CF

Ben Rice (L) DH

Aaron Judge (R) RF

Cody Bellinger (L) LF

Paul Goldschmidt (R) 1B

Jazz Chisholm Jr. (L) 3B

Anthony Volpe (R) SS

J.C. Escarra (L) C

DJ LeMahieu (R) 2B

Batting Average:  José Ramírez (.330)

Hits:  José Ramírez (71)

Home Runs:  José Ramírez (11)

RBI:  José Ramírez (29)

Stolen Bases:  José Ramírez (16)

Wins:  Gavin Williams (5)

Saves:  Emmanuel Clase (13)

ERA:  Hunter Gaddis (1.14)

Batting Average:  Aaron Judge (.387)

Hits:  Aaron Judge (86)

Home Runs:  Aaron Judge (21)

RBI:  Aaron Judge (50)

Stolen Bases:  Jasson Domínguez (8)

Wins:  Carlos Rodón (8)

Saves:  Luke Weaver (8)

ERA:  Adam Ottavino (0.00)

Managers:

Cleveland Guardians: Stephen Vogt (2nd season)

New York Yankees: Aaron Boone (8th season)