Cincinnati Reds vs St Louis Cardinals Prediction, Preview and Odds - 06/21/2025

Game Time: 2:15 pm ET, Saturday, June 21, 2025

Venue:  Busch Stadium, St. Louis, MO

Where to Watch:  FDSMW

DraftKings:  Moneyline odds:  Reds +152, Cardinals -187; Over/Under:  9 runs

Bet365:  Moneyline odds:  Reds +150, Cardinals -185; Over/Under:  9 runs

BetMGM:  Moneyline odds:  Reds +150, Cardinals -185; Over/Under:  9 runs

Cincinnati Reds:  39-36 (4th place, NL Central)

St Louis Cardinals:  40-35 (3rd place, NL Central)

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Cincinnati Reds:  7-3 last 10

St Louis Cardinals:  4-6 last 10

The Reds are entering this series off a loss and won their 3-game series against the Minnesota Twins 2-1 in their last series. They enter this game with a 39-36 record overall and have a road record of 19-19. This is the 2nd game of a 3-game series with the Cardinals on Saturday with the series opener still to be played on Friday. Their offense ranks 11th in the MLB with a .726 OPS. Brady Singer is their starting pitcher on Friday while Wade Miley is making his start in this game on Saturday. He is 1-0 with a 6.75 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 2 ER, 2 HR, and 2 BB with 5 SO on 4 hits through 5 IP against the Detroit Tigers.

The Cardinals are entering this series off a win and completed the sweep in their 3-game series against the Chicago White Sox 3-0 in their last series. They enter this game with a 40-35 record overall and have a home record of 22-14. This is the 2nd game of a 3-game series with the Reds on Saturday with the 1st game of this series still to be played on Friday. Their offense ranks 13th in the MLB with a .724 OPS. Andre Pallante is their starting pitcher on Friday while Sonny Gray is making his start in this game on Saturday. He is 7-2 with a 3.84 ERA this season. His team won 6 of their last 7 games this season with him making an appearance. In his last MLB regular season start, he allowed 6 earned runs, 1 homer, and 1 walk with 4 strikeouts on 8 hits through 4.1 innings pitched against the Milwaukee Brewers.

The current betting odds have the Cardinals listed as a favorite in this game according to Draftkings Sportsbook. The Reds have looked good in their games this season with their 39-36 record overall which has them right in the middle of the NL Central. They haven't been a great road team though with their 19-19 road record this season. Meanwhile, the Cardinals have looked good in their games this season with their 40-35 record overall, but that record has them right near the bottom of the NL Central in a competitive division. They have looked a lot better in their own ballpark though with their 22-14 home record this year. The Reds have been red hot lately as they are 7-3 in their last 10 games while the Cardinals have been in a slump, going 4-6 in their last 10 games, but the Cardinals do have the better pitching matchup in this one and they can take advantage of that. The Reds are going with Miley in this one and he hasn't had many starts this season, but he hasn't looked great in the few he has had. He is 1-0 with a 6.75 ERA and the team has won 2 games in a row now with him starting. He only gave up 2 earned runs in his last start too, but that hasn't been a common theme for him and he won't look as good against this lineup. The Cardinals are also going with Gray in this one and he has looked great this season. He is 7-2 with a 3.84 ERA and the team has had a ton of success with him starting. He did give up 6 earned runs in his last start, but that was a rare bad start for him and he will be looking to bounce back here, especially since his team has still won 6 of their last 7 games with him starting. Look for the Cardinals to take advantage of this better pitching matchup against a division rival. The best way to place a bet here is on the Cardinals to win this game. 

Reds Cardinals Prediction:  Our MLB Pick for Saturday, June 21, 2025 (2:15 pm ET start time) is Cardinals 7 Reds 2.

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Cincinnati Reds: 196-201 (+9.4 units) on the moneyline in all games. 110-126 (+21.1 units) on the moneyline as an underdog of +100 or higher. 100-99 (+24.9 units) on the moneyline in road games. 30-18 OVER on the road when the total is 9 to 9.5.

St Louis Cardinals: 193-205 (-24.2 units) on the moneyline in all games. 88-92 (-40.9 units) on the moneyline as a favorite of -110 or higher. 101-97 (-19 units) on the moneyline in home games. 9-4 OVER as a favorite of -125 to -175. 

Cincinnati Reds:  G. Ashcraft (RP) Fifteen Day IL - Groin. H. Greene (SP) Fifteen Day IL - Groin. R. Lowder (SP) Sixty Day IL - Forearm. A. Hays (LF) Ten Day IL - Foot. C. Spiers (RP) Sixty Day IL - Shoulder. T. Callihan (LF) Sixty Day IL - Forearm. N. Marte (3B) Ten Day IL - Side. J. Candelario (3B) Ten Day IL - Back. B. Williamson (SP) Sixty Day IL - Elbow. J. Aguiar (SP) Sixty Day IL - Elbow.

St Louis Cardinals:  Z. Thompson (RP) Sixty Day IL - Lat.

“I thought he had good stuff. I thought he made some mistakes and paid heavily for them. It seemed like that was the trend all day. Even in a couple of innings when we had two quick outs, we couldn’t get the third out, and it ended up driving everybody’s pitch count up, led to runs and it kind of led to an ugly day.” - Terry Francona after his team’s loss against the Twins in their game on Thursday.

“If you watch this guy day in and day out, how he works, how he goes about it, his preparation, how he handles failure, how he just continues to plow through. It’s hard to do what he does on the daily and play for as long as he has and put up the numbers that he has on both sides of the baseball. He wants to be a complete player, and to do what he did today is pretty damn special.” - Oliver Marmol after his team’s sweep of the White Sox in their double-header on Thursday.

TJ Friedl (L) CF

Gavin Lux (L) DH

Elly De La Cruz (S) SS

Tyler Stephenson (R) C

Spencer Steer (R) LF

Will Benson (L) RF

Christian Encarnacion-Strand (R) 1B

Santiago Espinal (R) 3B

Matt McLain (R) 2B

Brendan Donovan (L) 2B

Willson Contreras (R) 1B

Alec Burleson (L) RF

Nolan Arenado (R) 3B

Lars Nootbaar (L) LF

Nolan Gorman (L) DH

Pedro Pagés (R) C

Jose Barrero (R) SS

Victor Scott II (L) CF

Batting Average:  Austin Wynns (.400)

Hits:  TJ Friedl (80)

Home Runs:  Elly De La Cruz (16)

RBI:  Elly De La Cruz (50)

Stolen Bases:  Elly De La Cruz (21)

Wins:  Brady Singer (7)

Saves:  Emilio Pagán (17)

ERA:  Andrew Abbott (1.84)

Batting Average:  Thomas Saggese (.341)

Hits:  Brendan Donovan (83)

Home Runs:  Willson Contreras (10)

RBI:  Willson Contreras (50)

Stolen Bases:  Victor Scott (20)

Wins:  Sonny Gray (7)

Saves:  Ryan Helsley (14)

ERA:  Andre Granillo (0.00)

Managers:

Cincinnati Reds: Terry Francona (1st season)

St Louis Cardinals: Oliver Marmol (4th season)