Cincinnati Reds vs St Louis Cardinals Prediction, Preview and Odds - 06/20/2025

Game Time: 7:15 pm ET, Friday, June 20, 2025

Venue:  Busch Stadium, St. Louis, MO

Where to Watch:  FDSMW, Matrix Midwest

DraftKings:  Moneyline odds:  Reds +112, Cardinals -137; Over/Under:  9 runs

Bet365:  Moneyline odds:  Reds +115, Cardinals -135; Over/Under:  9 runs

BetMGM:  Moneyline odds:  Reds +115, Cardinals -140; Over/Under:  8.5 runs

Cincinnati Reds:  39-35 (3rd place, NL Central)

St Louis Cardinals:  38-35 (4th place, NL Central)

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Cincinnati Reds:  8-2 last 10

St Louis Cardinals:  3-7 last 10

The Reds won their 3-game series against the Detroit Tigers 2-1. They enter this game with a 39-35 record overall and have a road record of 19-19. This is the series opener of a 3-game series with the Cardinals on Friday with the series finale of their series against the Minnesota Twins still to be played on Thursday. The Reds won the series opener of that series on Tuesday and the 2nd game on Wednesday. Their offense ranks 10th in the MLB with a .727 OPS. Nick Martinez is their starting pitcher on Thursday while Brady Singer is making his start in this game on Friday. He is 7-4 with a 4.34 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 ER, 0 HR, and 3 BB with 4 SO on 4 hits through 6 IP against the Detroit Tigers.

The Cardinals lost their 4-game series against the Milwaukee Brewers 3-1. They enter this game with a 38-35 record overall and have a home record of 22-14. This is the 1st game of a 3-game series with the Reds on Friday with the 2nd game and the series finale of their series against the Chicago White Sox still to be played on Thursday in a double-header. The Cardinals won the 1st game of that series on Tuesday. Their offense ranks 13th in the MLB with a .721 OPS. Michael McGreevy is their starting pitcher on Thursday while Andre Pallante is making his start in this game on Friday. He is 4-3 with a 4.83 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 3 earned runs, 0 homers, and 2 walks with 7 strikeouts on 4 hits through 4.1 innings pitched against the Milwaukee Brewers.

The current betting odds have the Reds listed as an underdog in this game according to Draftkings Sportsbook. The Reds have looked good in their games this season with their 39-35 record overall which has them right in the middle of the NL Central. They haven't been a great road team though with their 19-19 road record this season. Meanwhile, the Cardinals have looked good in their games this season with their 38-35 record overall, but that record has them right near the bottom of the NL Central in a competitive division. They have looked a lot better in their own ballpark though with their 22-14 home record this year. The Cardinals haven't looked good lately though, going 3-7 in their last 10 games while the Reds have been getting red hot, going 8-2 in their last 10 games. Singer is on the mound for the Reds in this one and he has been a solid starter for them this year. He is 7-4 with a 4.34 ERA and he has looked a lot better lately. He only gave up 1 earned run in his last start and the team has won 2 games in a row now with him starting too. Pallante is on the mound for the Cardinals in this one and he has been really up and down this year. He is 4-3 with a 4.83 ERA and has been giving up some runs lately. He just gave up 3 earned runs in his last start which has been a common theme for him this year, and his team has lost 2 of their last 3 games with him starting too. The Reds are the much hotter team right now and can take advantage of this slumping Cardinals team. The best way to place a bet here is on the Reds to win this game. 

Reds Cardinals Prediction:  Our MLB Pick for Friday, June 20, 2025 (7:15 pm ET start time) is Reds 7 Cardinals 4.

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Cincinnati Reds: 196-200 (+10.4 units) on the moneyline in all games. 110-126 (+21.1 units) on the moneyline as an underdog of +100 or higher. 100-99 (+24.9 units) on the moneyline in road games. 4-1 OVER on the road after 6 consecutive games versus interleague opponents.

St Louis Cardinals: 191-205 (-26.2 units) on the moneyline in all games. 86-92 (-42.9 units) on the moneyline as a favorite of -110 or higher. 101-97 (-19 units) on the moneyline in home games. 8-4 OVER as a favorite of -125 to -175. 

Cincinnati Reds:  G. Ashcraft (RP) Fifteen Day IL - Groin. H. Greene (SP) Fifteen Day IL - Groin. R. Lowder (SP) Sixty Day IL - Forearm. A. Hays (LF) Ten Day IL - Foot. C. Spiers (RP) Sixty Day IL - Shoulder. T. Callihan (LF) Sixty Day IL - Forearm. N. Marte (3B) Ten Day IL - Side. J. Candelario (3B) Ten Day IL - Back. B. Williamson (SP) Sixty Day IL - Elbow. J. Aguiar (SP) Sixty Day IL - Elbow.

St Louis Cardinals:  Z. Thompson (RP) Sixty Day IL - Lat.

“Other than the first pitch of the game, he looked really good." - Terry Francona on Nick Lodolo after his team’s win against the Twins in their game on Wednesday. 

“We knew that he could spin it, but the poise has been great. His ability to game plan, study the game plan and study the opposition is exactly what you would want everyone in your ‘pen mimicking as far as preparation goes. And then he does a really nice job of sharing his knowledge. He’s been an awesome fit for us.” - Oliver Marmol on Phil Maton this season. 

TJ Friedl (L) CF

Gavin Lux (L) DH

Elly De La Cruz (S) SS

Tyler Stephenson (R) C

Spencer Steer (R) LF

Will Benson (L) RF

Christian Encarnacion-Strand (R) 1B

Santiago Espinal (R) 3B

Matt McLain (R) 2B

Masyn Winn (R) SS

Iván Herrera (R) C

Alec Burleson (L) DH

Willson Contreras (R) 1B

Nolan Gorman (L) 2B

Nolan Arenado (R) 3B

Lars Nootbaar (L) LF

Jordan Walker (R) RF

Victor Scott II (L) CF

Batting Average:  Austin Wynns (.400)

Hits:  TJ Friedl (77)

Home Runs:  Elly De La Cruz (16)

RBI:  Elly De La Cruz (50)

Stolen Bases:  Elly De La Cruz (21)

Wins:  Brady Singer (7)

Saves:  Emilio Pagán (17)

ERA:  Lyon Richardson (1.37)

Batting Average:  Thomas Saggese (.341)

Hits:  Brendan Donovan (83)

Home Runs:  Willson Contreras (9)

RBI:  Willson Contreras (45)

Stolen Bases:  Victor Scott (19)

Wins:  Sonny Gray (7)

Saves:  Ryan Helsley (13)

ERA:  Andre Granillo (0.00)

Managers:

Cincinnati Reds: Terry Francona (1st season)

St Louis Cardinals: Oliver Marmol (4th season)