Chicago Cubs vs Philadelphia Phillies Prediction, Preview and Odds - 06/10/2025

Game Time: 6:45 pm ET, Tuesday, June 10, 2025

Venue:  Citizens Bank Park, Philadelphia, PA 

Where to Watch:  NBCS-P

DraftKings:  Moneyline odds:  Cubs -105, Phillies -115; Over/Under:  9 runs

Bet365:  Moneyline odds:  Cubs -105, Phillies -115; Over/Under:  9 runs

BetMGM:  Moneyline odds:  Cubs -105, Phillies -115; Over/Under:  9 runs

Chicago Cubs:  40-25 (1st place, NL Central)

Philadelphia Phillies:  37-28 (2nd place, NL East)

Do not miss out on our expert handicapper analysis! Sean Murphy is on a HOT STREAK in the MLB on a 31-16-2 MLB RUN for +$10,650 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Chicago Cubs:  6-4 last 10

Philadelphia Phillies:  1-9 last 10

The Cubs are entering this series off a loss and lost their 3-game series against the Detroit Tigers 2-1 in their last series. They enter this game with a 40-25 record overall and have a road record of 20-14. This is the 2nd game of a 3-game series with the Phillies on Tuesday with the series opener still to be played on Monday. Their offense ranks 3rd in the MLB with a .774 OPS. Matthew Boyd is their starting pitcher on Monday while Colin Rea is making his start in this game on Tuesday. He is 4-2 with a 3.59 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 0 ER, 0 HR, and 1 BB with 0 Ks on 5 hits through 5.1 IP against the Washington Nationals.

The Phillies are entering this series off a loss and got swept in their 3-game series against the Pittsburgh Pirates 3-0 in their last series. They enter this game with a 37-28 record overall and have a home record of 19-12. This is the 2nd game of a 3-game series with the Cubs on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 10th in the MLB with a .721 OPS. Zack Wheeler is their starting pitcher on Monday while Mick Abel is making his start in this game on Tuesday. He is 1-0 with a 0.79 ERA this season. His team lost their last game this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 0 BB with 2 strikeouts on 3 hits through 5.1 innings played against the Toronto Blue Jays.

The current betting odds have the Phillies listed as a slight favorite in this game according to Draftkings Sportsbook. The Phillies have looked good in their games this season with their 37-28 record overall which has them right near the top of the NL East. They have also looked a lot better in their own ballpark with their 19-12 home record. Meanwhile, the Cubs have looked really good in their games this season with their 40-25 record overall which has them right at the top of the NL Central with one of the best records in the entire MLB. They have also been a good road team this year with their 20-14 road record. The Phillies have looked terrible lately as they are 1-9 in their last 10 games and just got swept in their last series too, but they are going to be looking to bounce back at home after such a bad stretch of losses and they do have a good pitching matchup here that they can take advantage of. Abel is on the mound for the Phillies in this one and he is still in his rookie season, but he has been lights out in his few starts this year. He is 1-0 with a 0.79 ERA as he has not been giving up many runs at all, and he will be looking to continue that in this game since his team desperately needs a win. The Cubs have struggled against better pitching this season, as good as they have been, and they are going to have Rea on the mound who hasn't looked great lately either. He was a lot better in his last start as he gave up no runs, but he is 4-2 with a 3.59 ERA this season and the team has lost 2 of the last 3 games he started in as he did give up quite a few runs in those. The Phillies need a bounce back series badly and this is a good game for them to get a win at home. The best way to place a bet here is on the Phillies to win this game. 

Cubs Phillies Prediction:  Our MLB Pick for Tuesday, June 10, 2025 (6:45 pm ET start time) is Phillies 5 Cubs 2.

Don't miss our champion handicappers free picks, best bets, and expert baseball picks today.  And if you enjoyed this Chicago Cubs Philadelphia Phillies prediction, be sure to drop by every day for our daily MLB projections and previews.

Chicago Cubs: 36-43 (-12.4 units) on the moneyline against NL East opponents. 88-110 (-25.9 units) on the moneyline when the money line is +125 to -125. 83-75 (-6.9 units) on the moneyline vs. a team slugging percentage .400 or worse on the season (NL). 34-21 UNDER in June games.

Philadelphia Phillies: 186-113 (+12.1 units) on the moneyline as a favorite of -110 or higher. 129-73 (+18.3 units) on the moneyline in home games. 157-113 (+9.2 units) on the moneyline against right-handed starters. 45-26 UNDER at home when the total is 9 to 9.5.

Chicago Cubs:  M. Amaya (C) Ten Day IL - Oblique. P. Hodge (RP) Fifteen Day IL - Oblique. E. Morgan (RP) Sixty Day IL - Elbow. S. Imanaga (SP) Fifteen Day IL - Leg. J. Assad (RP) Sixty Day IL - Oblique. J. Steele (SP) Sixty Day IL - Elbow.

Philadelphia Phillies:  B. Harper (1B) Ten Day IL - Wrist. A. Nola (SP) Fifteen Day IL - Ankle.

“We created that one scoring opportunity -- they made a nice defensive play again, frankly. That was really our opportunity. [Flaherty] was on. After that inning, he kind of got back locked in.” - Craig Counsell after his team’s loss against the Tigers in their game on Sunday.

"We'll see, you know? I've been thinking about some different things. We'll see what happens." - Rob Thomson after his team’s loss against the Pirates in their game on Sunday.

Ian Happ (S) DH

Kyle Tucker (L) RF

Seiya Suzuki (R) LF

Pete Crow-Armstrong (L) CF

Carson Kelly (R) C

Michael Busch (L) 1B

Dansby Swanson (R) SS

Nico Hoerner (R) 2B

Matt Shaw (R) 3B

Bryson Stott (L) 2B

Trea Turner (R) SS

Kyle Schwarber (L) DH

Alec Bohm (R) 1B

Nick Castellanos (R) RF

Max Kepler (L) LF

Otto Kemp (R) 3B

Brandon Marsh (L) CF

Rafael Marchán (S) C

Batting Average:  Nico Hoerner (.286)

Hits:  Pete Crow-Armstrong (71)

Home Runs:  Pete Crow-Armstrong (17)

RBI:  Seiya Suzuki (55)

Stolen Bases:  Pete Crow-Armstrong (21)

Wins:  Jameson Taillon (6)

Saves:  Daniel Palencia (5)

ERA:  Drew Pomeranz (0.00)

Batting Average:  Trea Turner (.300)

Hits:  Trea Turner (78)

Home Runs:  Kyle Schwarber (20)

RBI:  Kyle Schwarber (46)

Stolen Bases:  Trea Turner (17)

Wins:  Zack Wheeler (6)

Saves:  Jordan Romano (8)

ERA:  Mick Abel (0.79)

Managers:

Chicago Cubs: Craig Counsell (2nd season)

Philadelphia Phillies: Rob Thomson (4th season)