by Rod Pearson
Tuesday, Aug 05, 2025
Game Time: 4:10 pm ET, Wednesday, August 6, 2025
Venue: Dodger Stadium, Los Angeles, CA
Where to Watch: MLBN
Opening Odds at USA Sportsbooks
DraftKings: Moneyline odds: Cardinals +168, Dodgers -208; Over/Under: 8.5 runs
Bet365: Moneyline odds: Cardinals +170, Dodgers -210; Over/Under: 8.5 runs
BetMGM: Moneyline odds: Cardinals +170, Dodgers -210; Over/Under: 8.5 runs
Season Record
St Louis Cardinals: 57-57 (4th place, NL Central)
Los Angeles Dodgers: 65-48 (1st place, NL West)
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Recent Form
St Louis Cardinals: 4-6 last 10
Los Angeles Dodgers: 5-5 last 10
St Louis Cardinals vs Los Angeles Dodgers Preview and Analysis
The Cardinals are entering this series off a loss and lost their 3-game series against the San Diego Padres 2-1 in their last series. They enter this game with a 57-57 record overall and have a road record of 25-33. This is the series finale of a 3-game series with the Dodgers on Wednesday with the 2nd game still to be played on Tuesday. The Cardinals won the series opener on Monday. Their offense ranks 20th in the MLB with a .705 OPS. Miles Mikolas is their starting pitcher on Tuesday while Matthew Liberatore is making his start in this game on Wednesday. He is 6-9 with a 3.96 ERA this season. His team lost their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 ER, 0 HR, and 2 BB with 1 SO on 4 hits through 4.1 IP against the San Diego Padres.
The Dodgers are entering this series off a win and won their 3-game series against the Tampa Bay Rays 2-1 in their last series. They enter this game with a 65-48 record overall and have a home record of 35-22. This is the 3rd game of a 3-game series with the Cardinals on Wednesday with the 2nd game of this series still to be played on Tuesday. The Dodgers lost the 1st game of this series on Monday. Their offense ranks 2nd in the MLB with a .765 OPS. Emmet Sheehan is their starting pitcher on Tuesday while Shohei Ohtani is making his start in this game on Wednesday. He is 0-0 with a 2.40 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 0 homers, and 2 walks with 4 strikeouts on 5 hits through 3 innings pitched against the Cincinnati Reds.
Cardinals vs Dodgers Prediction
The current betting odds have the Dodgers listed as a favorite in this game according to Draftkings Sportsbook. The Dodgers have looked great in their games this season with their 65-48 record overall which has them right at the top of the NL West with one of the best records in the entire MLB. They have also looked great in their own ballpark this year with their 35-22 home record. Meanwhile, the Cardinals haven't looked great in their games this season with their 57-57 record overall which has them near the bottom of the NL Central. They have been a terrible road team too with their 25-33 road record this season. The Dodgers haven't been hot lately, but they just pulled themselves out of a huge slump that they were in and they are starting to get healthier now too. They are going to have Ohtani on the mound here and he has looked great in his few starts since coming back from injury. He is 0-0 with a 2.40 ERA and he hasn't been pitching deep into his starts, but he is coming off another good start in which he gave up 2 earned runs and the team has won 2 of their last 3 games with him starting too. The Cardinals are going with Liberatore in this one and he hasn't looked great this season. He is 6-9 with a 3.96 ERA and his team hasn't had a ton of success with him lately. He only gave up 1 earned run in his last start, but that hasn't been a common theme for him this year and the team has still lost 3 games in a row now with him starting. The Dodgers have been playing better lately and these are the kinds of series they need to take advantage at home against weaker opponents. The best way to place a bet here is on the Dodgers to win this game.
Cardinals Dodgers Prediction: Our MLB Pick for Wednesday, August 6, 2025 (4:10 pm ET start time) is Dodgers 5 Cardinals 0.
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MLB Betting Trends
St Louis Cardinals: 99-111 (+15 units) on the moneyline as an underdog of +100 or higher. 54-52 (+6.5 units) on the moneyline when playing against a good team (Win Pct. 54% to 62%). 66-65 (+13.2 units) on the moneyline vs. teams outscoring opp by 0.5 or more runs/game on the season. 22-15 UNDER on the road against NL West opponents.
Los Angeles Dodgers: 45-44 (-24.6 units) on the moneyline against NL Central opponents. 146-89 (-28.1 units) on the moneyline as a favorite of -150 or more. 160-124 (-9.2 units) on the moneyline vs. a team with a good bullpen whose WHIP is 1.350 or better. 37-26 UNDER vs. a team with a good bullpen whose WHIP is 1.350 or better.
Key Injuries
St Louis Cardinals: N. Arenado (3B) Ten Day IL - Shoulder. J. King (RP) Fifteen Day IL - Oblique. Z. Thompson (RP) Sixty Day IL - Lat.
Los Angeles Dodgers: T. Edman (2B) Ten Day - Ankle. K. Yates (RP) Fifteen Day IL - Back. H. Kim (2B) Ten Day IL - Shoulder. T. Scott (RP) Fifteen Day IL - Elbow. M. Kopech (RP) Sixty Day IL - Knee. E. Hernandez (1B) Ten Day IL - Elbow. R. Sasaki (SP) Sixty Day IL - Shoulder. T. Gonsolin (SP) Sixty Day IL - Elbow. E. Phillips (RP) Sixty Day IL - forearm. K. Hurt (SP) Sixty Day IL - Elbow. B. Graterol (RP) Sixty Day IL - Shoulder. M. Grove (RP) Sixty Day IL - Shoulder. R. Ryan (SP) Sixty Day IL - Elbow. G. Stone (SP) Sixty Day IL - Shoulder.
Notable Quotes
“More than anybody I’ve probably ever been around, he takes it all in and appreciates it every single day. There’s not a day where he shows up and says, ‘Gosh dang it, it’s hot out’ or ‘we’re playing 17 [days] in a row.’ It’s always a new day for him and he’s happy as hell to be out there.” - Oliver Marmol after his team’s win against the LA Dodgers in their game on Monday.
“We certainly missed him. He's put in a lot of work to get back with this timeline. And, yeah, we needed him. So to put him back somewhere in the middle of the order just kind of lengthens and strengthens our lineup.” - Dave Roberts on Max Muncy after his team’s loss against the Cardinals in their game on Monday.
Starting Lineups
St Louis Cardinals
Brendan Donovan (L) 2B
Iván Herrera (R) DH
Alec Burleson (L) LF
Willson Contreras (R) 1B
Lars Nootbaar (L) RF
Masyn Winn (R) SS
Thomas Saggese (R) 3B
Pedro Pagés (R) C
Victor Scott II (L) CF
Los Angeles Dodgers
Shohei Ohtani (L) DH
Mookie Betts (R) SS
Freddie Freeman (L) 1B
Will Smith (R) C
Max Muncy (L) 3B
Teoscar Hernández (R) RF
Michael Conforto (L) LF
Andy Pages (R) CF
Miguel Rojas (R) 2B
Statistical Leaders
St Louis Cardinals
Batting Average: José Fermín (.350)
Hits: Brendan Donovan (112)
Home Runs: Willson Contreras (15)
RBI: Willson Contreras (63)
Stolen Bases: Victor Scott (29)
Wins: Sonny Gray (10)
Saves: Ryan Helsley (21)
ERA: Riley O'Brien (1.93)
Los Angeles Dodgers
Batting Average: Will Smith (.321)
Hits: Shohei Ohtani (119)
Home Runs: Shohei Ohtani (38)
RBI: Shohei Ohtani (73)
Stolen Bases: Shohei Ohtani (15)
Wins: Yoshinobu Yamamoto (10)
Saves: Tanner Scott (19)
ERA: Evan Phillips (0.00)
Managers:
St Louis Cardinals: Oliver Marmol (4th season)
Los Angeles Dodgers: Dave Roberts (10th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
