St Louis Cardinals vs Los Angeles Dodgers Prediction, Preview and Odds - 08/05/2025

by Rod Pearson

Monday, Aug 04, 2025
Game Time: 10:10 pm ET, Tuesday, August 5, 2025
Venue:  Dodger Stadium, Los Angeles, CA 
Where to Watch:  MLBN


Opening Odds at USA Sportsbooks

DraftKings:  Moneyline odds:  Cardinals +150, Dodgers -180; Over/Under:  9 runs
Bet365:  Moneyline odds:  Cardinals +150, Dodgers -180; Over/Under:  9 runs
BetMGM:  Moneyline odds:  Cardinals +150, Dodgers -180; Over/Under:  9 runs

Season Record

St Louis Cardinals:  56-57 (4th place, NL Central)
Los Angeles Dodgers:  65-47 (1st place, NL West)

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Recent Form
St Louis Cardinals:  4-6 last 10
Los Angeles Dodgers:  6-4 last 10



St Louis Cardinals vs Los Angeles Dodgers Preview and Analysis


The Cardinals are entering this series off a loss and lost their 3-game series against the San Diego Padres 2-1 in their last series. They enter this game with a 56-57 record overall and have a road record of 24-33. This is the 2nd game of a 3-game series with the Dodgers on Tuesday with the series opener still to be played on Monday. Their offense ranks 20th in the MLB with a .707 OPS. Sonny Gray is their starting pitcher on Monday while Miles Mikolas is making his start in this game on Tuesday. He is 6-8 with a 4.83 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 2 ER, 1 HR, and 0 BB with 5 SO on 5 hits through 6 IP against the Miami Marlins.

The Dodgers are entering this series off a win and won their 3-game series against the Tampa Bay Rays 2-1 in their last series. They enter this game with a 65-47 record overall and have a home record of 35-21. This is the 2nd game of a 3-game series with the Cardinals on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 2nd in the MLB with a .768 OPS. Tyler Glasnow is their starting pitcher on Monday while Emmet Sheehan is making his start in this game on Tuesday. He is 2-2 with a 3.60 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 3 walks with 5 strikeouts on 1 hit through 3.2 innings pitched against the Cincinnati Reds.


Cardinals vs Dodgers Prediction

The current betting odds have the Dodgers listed as a favorite in this game according to Draftkings Sportsbook. The Dodgers have looked great in their games this season with their 65-47 record overall which has them right at the top of the NL West with one of the best records in the entire MLB. They have also looked great in their own ballpark this year with their 35-21 home record. Meanwhile, the Cardinals haven't looked great in their games this season with their 56-57 record overall which has them near the bottom of the NL Central. They have been a terrible road team too with their 24-33 road record this season. The Cardinals haven't looked too good lately either, going 4-6 in their last 10 games while the Dodgers are 6-4 and have been pulling themselves out of a slump that they were in. The Dodgers have one of the best offenses in the MLB too and they also have the better pitching matchup here. Sheehan is on the mound for the Dodgers and he has looked good this season. He is 2-2 with a 3.60 ERA and hasn't been giving up many runs lately. His team has struggled more lately, losing 2 of the last 3 games he started in, but he is coming off a great start in which he gave up no runs and that has been a common theme for him. The Cardinals are going with Mikolas in this one and he hasn't looked good this season. He is 6-8 with a 4.83 ERA and has been giving up quite a few runs all year. He only gave up 2 earned runs in his last start, but that hasn't been a common theme for him this year as he has had some really bad starts on the road, and his team has lost 2 of their last 3 games with him starting too. The best way to place a bet here is on the Dodgers to win this game.

Cardinals Dodgers Prediction:  Our MLB Pick for Tuesday, August 5, 2025 (10:10 pm ET start time) is Dodgers 8 Cardinals 4.
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MLB Betting Trends


St Louis Cardinals: 98-111 (+13.4 units) on the moneyline as an underdog of +100 or higher. 53-52 (+5 units) on the moneyline when playing against a good team (Win Pct. 54% to 62%). 65-65 (+11.7 units) on the moneyline vs. teams outscoring opp by 0.5 or more runs/game on the season. 52-30 UNDER as an underdog of +125 to +175.

Los Angeles Dodgers: 45-43 (-22.9 units) on the moneyline against NL Central opponents. 146-88 (-26.5 units) on the moneyline as a favorite of -150 or more. 160-123 (-7.5 units) on the moneyline vs. a team with a good bullpen whose WHIP is 1.350 or better. 36-26 UNDER vs. a team with a good bullpen whose WHIP is 1.350 or better.

Key Injuries


St Louis Cardinals:  B. Donovan (2B) Day To Day - Personal. N. Arenado (3B) Ten Day IL - Shoulder. J. King (RP) Fifteen Day IL - Oblique. Z. Thompson (RP) Sixty Day IL - Lat.

Los Angeles Dodgers:  T. Edman (2B) Day To Day - Ankle. K. Yates (RP) Fifteen Day IL - Back. H. Kim (2B) Ten Day IL - Shoulder. T. Scott (RP) Fifteen Day IL - Elbow. M. Kopech (RP) Sixty Day IL - Knee. E. Hernandez (1B) Ten Day IL - Elbow. M. Muncy (3B) Ten Day IL - Knee. R. Sasaki (SP) Sixty Day IL - Shoulder. T. Gonsolin (SP) Sixty Day IL - Elbow. E. Phillips (RP) Sixty Day IL - forearm. K. Hurt (SP) Sixty Day IL - Elbow. B. Graterol (RP) Sixty Day IL - Shoulder. M. Grove (RP) Sixty Day IL - Shoulder. R. Ryan (SP) Sixty Day IL - Elbow. G. Stone (SP) Sixty Day IL - Shoulder.


Notable Quotes


“The end of the game, that’s a learned skill to be able to never give in and figure out a way. You come in the dugout and you’re down a ton, and they wanted to get Suarez in the game. The fact we did that, it was impressive.” - Oliver Marmol after his team’s loss against the Padres in their game on Sunday.


"It was tough. You try not to talk about it too much, and I was trying to mix and match the lineup as much as possible. But it was tough, especially on the back end of a 10-day road trip. You have two of the hotter cities in Cincinnati and Tampa, and a couple day games here." - Dave Roberts after his team’s win against the Rays in their game on Sunday.


Starting Lineups


St Louis Cardinals
Masyn Winn (R) SS
Iván Herrera (R) LF
Alec Burleson (L) 1B
Willson Contreras (R) DH
Nolan Gorman (L) 3B
Jordan Walker (R) RF
Yohel Pozo (R) C
Thomas Saggese (R) 2B
Victor Scott II (L) CF

Los Angeles Dodgers
Shohei Ohtani (L) DH
Mookie Betts (R) SS
Freddie Freeman (L) 1B
Will Smith (R) C
Michael Conforto (L) LF
Andy Pages (R) CF
Alex Freeland (S) 3B
Tommy Edman (S) 2B
Alex Call (R) RF

Statistical Leaders


St Louis Cardinals
Batting Average:  José Fermín (.350)
Hits:  Brendan Donovan (112)
Home Runs:  Willson Contreras (15)
RBI:  Willson Contreras (63)
Stolen Bases:  Victor Scott (29)
Wins:  Sonny Gray (10)
Saves:  Ryan Helsley (21)
ERA:  Riley O'Brien (1.67)

Los Angeles Dodgers
Batting Average:  Will Smith (.324)
Hits:  Shohei Ohtani (118)
Home Runs:  Shohei Ohtani (38)
RBI:  Shohei Ohtani (73)
Stolen Bases:  Shohei Ohtani (15)
Wins:  Yoshinobu Yamamoto (10)
Saves:  Tanner Scott (19)
ERA:  Evan Phillips (0.00)

Managers:
St Louis Cardinals: Oliver Marmol (4th season)
Los Angeles Dodgers: Dave Roberts (10th season)


Rod Pearson

About the Author:

Rod Pearson has been a rabid sports fan his entire life.  He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years.  In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective.  Join Rod every day as he breaks down the games to find the best betting value.

All photographic images used for editorial content have been licensed from the Associated Press.

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