San Diego Padres vs Arizona Diamondbacks Prediction, Preview and Odds - 08/06/2025

Game Time: 9:40 pm ET, Wednesday, August 6, 2025

Venue:  Chase Field, Phoenix, AZ 

Where to Watch:  MLBN

DraftKings:  Moneyline odds:  Padres -144, Diamondbacks +118; Over/Under:  9.5 runs

Bet365:  Moneyline odds:  Padres -140, Diamondbacks +120; Over/Under:  9.5 runs

BetMGM:  Moneyline odds:  Padres -140, Diamondbacks +120; Over/Under:  9.5 runs

San Diego Padres:  62-51 (2nd place, NL West)

Arizona Diamondbacks:  54-59 (4th place, NL West)

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San Diego Padres:  7-3 last 10

Arizona Diamondbacks:  4-6 last 10

The Padres are entering this series off a win and won their 3-game series against the St Louis Cardinals 2-1 in their last series. They enter this game with a 62-51 record overall and have a road record of 26-32. This is the series finale of a 3-game series with the Diamondbacks on Wednesday with the 2nd game still to be played on Tuesday. The Padres lost the series opener on Monday. Their offense ranks 22nd in the MLB with a .698 OPS. Yu Darvish is their starting pitcher on Tuesday while Nestor Cortes is making his start in this game on Wednesday. He is 1-1 with a 9.00 ERA this season. His team won their last game this season with him making an appearance. In his last MLB regular season start, he allowed 0 ER, 0 HR, and 2 BB with 6 SO on 1 hit through 6 IP against the Cincinnati Reds.

The Diamondbacks are entering this series off a win and won their 3-game series against the Athletics 2-1 in their last series. They enter this game with a 54-59 record overall and have a home record of 27-28. This is the 3rd game of a 3-game series with the Padres on Wednesday with the 2nd game of this series still to be played on Tuesday. The Diamondbacks won the 1st game of this series on Monday. Their offense ranks 3rd in the MLB with a .762 OPS. Ryne Nelson is their starting pitcher on Tuesday while Anthony DeSclafani is making his start in this game on Wednesday. He is 1-2 with a 4.91 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 4 earned runs, 1 homer, and 3 walks with 0 strikeouts on 5 hits through 2.1 innings pitched against the Athletics.

The current betting odds have the Padres listed as a favorite in this game according to Draftkings Sportsbook. The Diamondbacks haven't looked great in their games this season with their 54-59 record overall which has them right near the bottom of the NL West. They haven't looked great in their own ballpark either with their 27-28 road record this season. Meanwhile, the Padres have looked really good in their games this season with their 62-51 record overall which has them right near the top of the NL West. They haven't been a great road team though with their 26-32 road record this year. The Padres have been red hot lately though, going 7-3 in their last 10 games while the Diamondbacks are only 4-6 in their last 10. The Padres have looked great since the All-Star break and this is a pitching matchup that they can take advantage of. Cortes is on the mound for the Padres in this one and he hasn't looked good in his few starts this season. He is 1-1 with a 9.00 ERA and looked terrible in his first start of the year, but he looked a lot better in his last one. He is coming off a great start in which he gave up no runs in 6 innings and the team won that game too. The Diamondbacks are going with DeSclafani in this one and he hasn't looked that great this year either. He is 1-2 with a 4.91 ERA and hasn't been getting many starts. He has been a reliever for a lot of the year, but he did get a chance to start in his last appearance and wasn't great. He pitched less than 3 innings in that start and gave up 4 earned runs. He is going to get another chance to start here, but he hasn't been reliable as a starter this season and the Padres are starting to roll now. The best way to place a bet here is on the Padres to win this game. 

Padres Diamondbacks Prediction:  Our MLB Pick for Wednesday, August 6, 2025 (9:40 pm ET start time) is Padres 5 Diamondbacks 3.

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San Diego Padres: 164-120 (-14.4 units) on the moneyline as a favorite of -110 or higher. 70-66 (-10.1 units) on the moneyline against division opponents. 166-147 (-9.5 units) on the moneyline against right-handed starters. 10-5 UNDER when the total is 9 to 9.5.

Arizona Diamondbacks: 236-218 (+6.6 units) on the moneyline in all games. 100-112 (+17.3 units) on the moneyline as an underdog of +100 or higher. 76-60 (+15.9 units) on the moneyline against division opponents. 9-5 UNDER at home against left-handed starters.

San Diego Padres:  M. King (SP) Sixty Day IL - Shoulder. J. Brito (RP) Sixty Day IL - Forearm. J. Musgrove (SP) Sixty Day IL - Elbow.

Arizona Diamondbacks:  K. Ginkel (RP) Fifteen Day IL - Shoulder. G. Moreno (C) Sixty Day IL - Hand. P. Smith (1B) Ten Day IL - Oblique. T. Henry (RP) Sixty Day IL - Elbow. R. Thompson (RP) Fifteen Day IL - Scapular Strain. I. Vargas (2B) Ten Day IL - Foot. C. Montes De Oca (RP) Sixty Day IL - Elbow. J. Martinez (RP) Sixty Day IL - Elbow. C. Mena (SP) Sixty Day IL - Shoulder. C. Burnes (SP) Sixty Day IL - Elbow. A. Puk (RP) Sixty Day IL - Elbow. B. Walston (SP) Sixty Day IL - Elbow.

“He's a real competitor. He wanted to go out for as long as he could, as far as he could. So really, really respect the way he competed.” - Mike Shildt after his team’s loss against the Diamondbacks in their game on Monday.

“We left, we were a team. We came back, and we're not [the same].” - Torey Lovullo after his team’s win against the Padres in their game on Monday.

Fernando Tatis Jr. (R) RF

Luis Arraez (L) 1B

Manny Machado (R) 3B

Jackson Merrill (L) CF

Xander Bogaerts (R) SS

Gavin Sheets (L) DH

Ramón Laureano (R) LF

Jake Cronenworth (L) 2B

Freddy Fermin (R) C

Ketel Marte (S) 2B

Corbin Carroll (L) DH

Geraldo Perdomo (S) SS

Lourdes Gurriel Jr. (R) LF

Tyler Locklear (R) 1B

James McCann (R) C

Blaze Alexander (R) 3B

Alek Thomas (L) CF

Jorge Barrosa (S) RF

Batting Average:  Freddy Fermin (.333)

Hits:  Manny Machado (130)

Home Runs:  Manny Machado (20)

RBI:  Manny Machado (72)

Stolen Bases:  Fernando Tatis (22)

Wins:  Nick Pivetta (11)

Saves:  Robert Suarez (32)

ERA:  Bradgley Rodriguez (0.00)

Batting Average:  Josh Naylor (.292)

Hits:  Geraldo Perdomo (114)

Home Runs:  Eugenio Suárez (36)

RBI:  Eugenio Suárez (87)

Stolen Bases:  Geraldo Perdomo (17)

Wins:  Brandon Pfaadt (11)

Saves:  Shelby Miller (10)

ERA:  Christian Montes De Oca (0.00)

Managers:

San Diego Padres: Mike Shildt (2nd season)

Arizona Diamondbacks: Torey Lovullo (9th season)