Philadelphia Phillies vs New York Yankees Prediction, Preview and Odds - 07/25/2025

Game Time: 7:05 pm ET, Friday, July 25, 2025

Venue:  Yankee Stadium, Bronx, NY

Where to Watch:  Apple TV+

DraftKings:  Moneyline odds:  Phillies +128, Yankees -157; Over/Under:  9.5 runs

Bet365:  Moneyline odds:  Phillies +130, Yankees -155; Over/Under:  9.5 runs

BetMGM:  Moneyline odds:  Phillies +130, Yankees -155; Over/Under:  9.5 runs

Philadelphia Phillies:  58-44 (2nd place, NL East)

New York Yankees:  56-46 (2nd place, AL East)

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Philadelphia Phillies:  5-5 last 10

New York Yankees:  5-5 last 10

The Phillies are entering this series off a loss and won their 3-game series against the Boston Red Sox 2-1 in their last series. They enter this game with a 58-44 record overall and have a road record of 25-25. This is the series opener of a 3-game series with the Yankees on Friday and they have Thursday off as a day of rest. Their offense ranks 8th in the MLB with a .735 OPS. Jesús Luzardo was their starting pitcher on Wednesday while Taijuan Walker is making his start in this game on Friday. He is 3-5 with a 3.75 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 3 ER, 2 HR, and 1 BB with 4 SO on 9 hits through 4 IP against the Los Angeles Angels.

The Yankees are entering this series off a loss and lost their 3-game series against the Toronto Blue Jays 2-1 in their last series. They enter this game with a 56-46 record overall and have a home record of 30-19. This is the 1st game of a 3-game series with the Phillies on Friday and they have Thursday off as a day of rest. Their offense ranks 1st in the MLB with a .787 OPS. Max Fried was their starting pitcher on Wednesday while Will Warren is making his start in this game on Friday. He is 6-5 with a 4.91 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 5 earned runs, 2 homers, and 3 walks with 5 strikeouts on 5 hits through 3.2 innings pitched against the Atlanta Braves.

The current betting odds have the Phillies listed as an underdog in this game according to Draftkings Sportsbook. The Phillies have looked really good in their games this season with their 58-44 record overall which has them right near the top of the NL East. They haven't been a great road team though with their 25-25 road record this season. Meanwhile, the Yankees have looked really good in their games this season with their 56-46 record overall which has them right near the top of the AL East. They have looked great in their own ballpark too with their 30-19 home record this year. Neither team has really been hot lately, but the Phillies are coming off a series win while the Yankees are coming off a series loss and this is a pitching matchup that the Phillies can take advantage of. The Phillies are going with Walker in this one and he has looked good this season. He is 3-5 with a 3.75 ERA and hasn't been giving up a lot of runs in his starts. The team has lost 2 of their last 3 games with him starting and he did give up 3 earned runs in his last start too, but the Phillies have also been really hot on offense since coming out of the All-Star break so Walker is going to get some run support here. The Yankees are going with Warren in this one and he hasn't looked great this season. He is 6-5 with a 4.91 ERA and has been giving up some runs lately. He is coming off another bad start in which he gave up 5 earned runs and that has been a common theme for him. The Yankees also have a good offense to help him out here, but they weren't great in their last series so the Phillies have the slight edge with Walker on the mound. The best way to place a bet here is on the Phillies to win this game. 

Phillies Yankees Prediction:  Our MLB Pick for Friday, July 25, 2025 (7:05 pm ET start time) is Phillies 7 Yankees 6.

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Philadelphia Phillies: 27-17 (+7.7 units) on the moneyline against AL East opponents. 68-48 (+7.8 units) on the moneyline in an inter-league game. 175-126 (+10.8 units) on the moneyline against right-handed starters. 9-4 OVER after 6 consecutive games versus interleague opponents.

New York Yankees: 18-23 (-12.3 units) on the moneyline against NL East opponents. 239-200 (-27.3 units) on the moneyline in all games. 120-98 (-27 units) on the moneyline in home games. 18-8 OVER vs. NL teams allowing 4.0 or less runs/game on the season.

Philadelphia Phillies:  J. Ross (RP) Fifteen Day IL - Back. A. Bohm (3B) Ten Day IL - Ribcage. A. Nola (SP) Sixty Day IL - Ankle.

New York Yankees:  C. Schmidt (SP) Fifteen Day IL - Forearm. M. Leiter Jr. (RP) Fifteen Day IL - Fibular. F. Cruz (RP) Fifteen Day IL - Oblique. R. Yarbrough (SP) Fifteen Day IL - Oblique. Y. De Los Santos (RP) Fifteen Day IL - Elbow. O. Cabrera (3B) Sixty Day IL - Ankle. J. Cousins (RP) Sixty Day IL - Elbow. L. Gil (SP) Sixty Day IL - Back. G. Cole (SP) Sixty Day IL - Elbow.

“Yeah, pretty awesome, obviously on an individual note. Super happy about it." - Bryce Harper on hitting 350 career homers in their loss against the Red Sox on Wednesday.

“Giving them extra outs, whether it’s through making an error or not making a play that we need to make, that’s cost us in these two series up here. We’ve got to obviously tighten it up. We’ll continue to work at it. We have good defenders here, but tonight was obviously a rough night.” - Aaron Boone after his team’s loss against the Blue Jays in their game on Wednesday.

Trea Turner (R) SS

Kyle Schwarber (L) DH

Bryce Harper (L) 1B

Nick Castellanos (R) RF

J.T. Realmuto (R) C

Brandon Marsh (L) CF

Max Kepler (L) LF

Edmundo Sosa (R) 3B

Bryson Stott (L) 2B

Trent Grisham (L) CF

Cody Bellinger (L) RF

Aaron Judge (R) DH

Ben Rice (L) 1B

Jazz Chisholm Jr. (L) 2B

Jasson Domínguez (S) LF

Anthony Volpe (R) SS

J.C. Escarra (L) C

Oswald Peraza (R) 3B

Batting Average:  Trea Turner (.290)

Hits:  Trea Turner (119)

Home Runs:  Kyle Schwarber (34)

RBI:  Kyle Schwarber (78)

Stolen Bases:  Trea Turner (25)

Wins:  Zack Wheeler (9)

Saves:  Jordan Romano (8)

ERA:  Daniel Robert (1.42)

Batting Average:  Aaron Judge (.345)

Hits:  Aaron Judge (129)

Home Runs:  Aaron Judge (37)

RBI:  Aaron Judge (84)

Stolen Bases:  Jasson Domínguez (14)

Wins:  Max Fried (11)

Saves:  Devin Williams (15)

ERA:  Adam Ottavino (0.00)

Managers:

Philadelphia Phillies: Rob Thomson (4th season)

New York Yankees: Aaron Boone (8th season)