New York Yankees vs Toronto Blue Jays Prediction, Preview and Odds - 07/22/2025

Game Time: 7:07 pm ET, Tuesday, July 22, 2025

Venue:  Rogers Centre, Toronto, ON

Where to Watch:  YES, Sportsnet

DraftKings:  Moneyline odds:  Yankees +101, Blue Jays -123; Over/Under:  9 runs

Bet365:  Moneyline odds:  Yankees +100, Blue Jays -120; Over/Under:  9 runs

BetMGM:  Moneyline odds:  Yankees +100, Blue Jays -120; Over/Under:  9 runs

New York Yankees:  55-44 (2nd place, AL East)

Toronto Blue Jays:  58-41 (1st place, AL East)

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New York Yankees:  7-3 last 10

Toronto Blue Jays:  7-3 last 10

The Yankees are entering this series off a win and won their 3-game series against the Atlanta Braves 2-1 in their last series. They enter this game with a 55-44 record overall and have a road record of 25-25. This is the 2nd game of a 3-game series with the Blue Jays on Tuesday with the series opener still to be played on Monday. Their offense ranks 1st in the MLB with a .791 OPS. Carlos Rodón is their starting pitcher on Monday while rookie pitcher Cam Schlittler is making his start in this game on Tuesday. He is 1-0 with a 5.06 ERA this season. His team won their only game this season with him making an appearance. In his last MLB regular season start, he allowed 3 ER, 2 HR, and 2 BB with 7 SO on 4 hits through 5.1 IP against the Seattle Mariners.

The Blue Jays are entering this series off a win and completed the sweep in their 3-game series against the San Francisco Giants 3-0 in their last series. They enter this game with a 58-41 record overall and have a home record of 35-16. This is the 2nd game of a 3-game series with the Yankees on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 6th in the MLB with a .741 OPS. Kevin Gausman is their starting pitcher on Monday while Max Scherzer is making his start in this game on Tuesday. He is 1-0 with a 4.70 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 3 earned runs, 2 homers, and 1 walk with 8 strikeouts on 5 hits through 6 innings pitched against the Athletics.

The current betting odds have the Blue Jays listed as a slight favorite in this game according to Draftkings Sportsbook. The Blue Jays have looked great in their games this season with their 58-41 record overall which has them right at the top of the AL East. They have looked great in their own ballpark too with their 35-16 home record this season. Meanwhile, the Yankees have looked really good in their games this season with their 55-44 record overall which has them right near the top of the AL East. They haven't been a great road team though with their 25-25 road record this season. Both of these teams have been hot coming into this series as both are 7-3 in their last 10 games, but the Blue Jays have been rolling as they just swept the Giants out of the All-Star break, and they also have the better pitching matchup too. The Blue Jays are going with Scherzer in this one and he hasn't been at his best this season, but he is still a reliable veteran starter and is a much better option than what the Yankees have in this one. Scherzer is 1-0 with a 4.70 ERA and hasn't looked bad lately. He did give up 3 earned runs in his last start, but the team has still won 3 games in a row with him starting and they have the hotter offense right now too. Schlittler is starting for the Yankees in this one and he doesn't have a ton of experience, only making his 2nd ever MLB start here. He is 1-0 with a 5.06 ERA since his team won 9-6 in his only start, but he did give up 3 earned runs and the bullpen wasn't much help either. This is a matchup that the Blue Jays can take advantage of and they have looked like a completely different team at home this year. The best way to place a bet here is on the Blue Jays to win this game. 

Yankees Blue Jays Prediction:  Our MLB Pick for Tuesday, July 22, 2025 (7:07 pm ET start time) is Blue Jays 7 Yankees 4.

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New York Yankees: 50-51 (+10.6 units) on the moneyline as an underdog of +100 or higher. 117-72 (+10.3 units) on the moneyline vs. an AL team with a slugging percentage .410 or worse on the season. 126-106 (+7.1 units) on the moneyline when playing against a team with a winning record. 9-2 OVER after 6 consecutive games versus interleague opponents.

Toronto Blue Jays: 221-204 (-12.7 units) on the moneyline in all games. 117-96 (-10.2 units) on the moneyline in home games. 128-105 (-23.5 units) on the moneyline as a favorite of -110 or higher. 32-15 OVER vs. an AL team with a slugging percentage of .440 or better on the season.

New York Yankees:  M. Fried (SP) Day To Day - Finger. C. Schmidt (SP) Fifteen Day IL - Forearm. M. Leiter Jr. (RP) Fifteen Day IL - Fubular. F. Cruz (RP) Fifteen Day IL - Oblique. R. Yarbrough (SP) Fifteen Day IL - Oblique. Y. De Los Santos (RP) Fifteen Day IL - Elbow. O. Cabrera (3B) Sixty Day IL - Ankle. J. Cousins (RP) Sixty Day IL - Elbow. L. Gil (SP) Sixty Day IL - Back. G. Cole (SP) Sixty Day IL - Elbow.

Toronto Blue Jays:  R. Burr (RP) Sixty Day IL - Shoulder. N. Sandlin (RP) Fifteen Day IL - Elbow. A. Gimenez (2B) Ten Day IL - Ankle. Y. Garcia (RP) Fifteen Day IL - Ankle. A. Santander (RF) Sixty Day IL - Shoulder. P. Schultz (RP) Fifteen Day IL - Middle Finger. B. Francis (SP) Fifteen Day IL - Shoulder. D. Varsho (CF) Ten Day IL - Hamstring. A. Manoah (SP) Sixty Day IL - Elbow. A. Bastardo (SP) Sixty Day IL - Elbow.

“I thought he continued to do a nice job of mixing and matching. Staying unpredictable, using all his pitches and using both sides of the plate. Ben did a great job with him back there.” - Aaron Boone after his team’s win against the Braves in their game on Sunday.

“I've said this [before]. It takes one swing, one game, for him to really get going. We've seen that so many times with him, over and over again. I just want him to continue to take aggressive swings.” - John Schneider after his team’s win against the Giants in their game on Sunday.

Jasson Domínguez (S) LF

Aaron Judge (R) RF

Cody Bellinger (L) CF

Giancarlo Stanton (R) DH

Jazz Chisholm Jr. (L) 2B

Paul Goldschmidt (R) 1B

Ben Rice (L) C

Anthony Volpe (R) SS

Jorbit Vivas (L) 3B

Ernie Clement (R) 3B

George Springer (R) DH

Vladimir Guerrero Jr. (R) 1B

Bo Bichette (R) SS

Alejandro Kirk (R) C

Addison Barger (L) RF

Davis Schneider (R) LF

Leo Jiménez (R) 2B

Myles Straw (R) CF

Batting Average:  Aaron Judge (.352)

Hits:  Aaron Judge (128)

Home Runs:  Aaron Judge (36)

RBI:  Aaron Judge (82)

Stolen Bases:  Jasson Domínguez (14)

Wins:  Max Fried (11)

Saves:  Devin Williams (14)

ERA:  Adam Ottavino (0.00)

Batting Average:  Joey Loperfido (.348)

Hits:  Bo Bichette (114)

Home Runs:  George Springer (17)

RBI:  Bo Bichette (55)

Stolen Bases:  George Springer (12)

Wins:  Chris Bassitt (10)

Saves:  Jeff Hoffman (23)

ERA:  Ryan Burr (0.00)

Managers:

New York Yankees: Aaron Boone (8th season)

Toronto Blue Jays: John Schneider (4th season)