New York Mets vs San Francisco Giants Prediction, Preview and Odds - 07/25/2025

Game Time: 10:15 pm ET, Friday, July 25, 2025

Venue:  Oracle Park, San Francisco, CA

Where to Watch:  SNY, NBCS-BA

DraftKings:  Moneyline odds:  Mets +118, Giants -144; Over/Under:  7 runs

Bet365:  Moneyline odds:  Mets +120, Giants -140; Over/Under:  7 runs

BetMGM:  Moneyline odds:  Mets +120, Giants -140; Over/Under:  7.5 runs

New York Mets:  59-44 (1st place, NL East)

San Francisco Giants:  54-49 (3rd place, NL West)

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New York Mets:  6-4 last 10

San Francisco Giants:  3-7 last 10

The Mets are entering this series off a win and completed the sweep in their 3-game series against the Los Angeles Angels 3-0 in their last series. They enter this game with a 59-44 record overall and have a road record of 22-28. This is the series opener of a 3-game series with the Giants on Friday and they have Thursday off as a day of rest. Their offense ranks 10th in the MLB with a .733 OPS. Sean Manaea was their starting pitcher on Wednesday while Clay Holmes is making his start in this game on Friday. He is 8-5 with a 3.48 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 4 ER, 0 HR, and 2 BB with 3 SO on 6 hits through 5.1 IP against the Cincinnati Reds.

The Giants are entering this series off a win and won their 3-game series against the Atlanta Braves 2-1 in their last series. They enter this game with a 54-49 record overall and have a home record of 28-20. This is the 1st game of a 3-game series with the Mets on Friday and they have Thursday off as a day of rest. Their offense ranks 24th in the MLB with a .687 OPS. Justin Verlander was their starting pitcher on Wednesday while Logan Webb is making his start in this game on Friday. He is 9-7 with a 3.08 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 4 earned runs, 0 homers, and 1 walk with 1 strikeout on 11 hits through 6 innings pitched against the Toronto Blue Jays.

The current betting odds have the Giants listed as a favorite in this game according to Draftkings Sportsbook. The Giants have looked good in their games this season with their 54-49 record overall which has them right in the middle of the NL West. They have also looked a lot better in their own ballpark this year with their 28-20 home record. Meanwhile, the Mets have looked great in their games this season with their 59-44 record overall which has them right at the top of the NL East. They haven't been a good road team though with their 22-28 road record this season. The Mets have been the hotter team lately as they are 6-4 in their last 10 games and just swept the Angels in their last series while the Giants are only 3-7 in their last 10 games, but the Giants have also won 2 games in a row now and they have the better pitching matchup here at home. Webb is on the mound for the Giants in this one and he has looked great this season. He is 9-7 with a 3.08 ERA and hasn't been giving up many runs all year. He did give up 4 earned runs in his last start, but that hasn't been a common theme for him and the team has still won 2 of their last 3 games with him starting too. The Mets are going with Holmes in this one and he has looked good this season too. He is 8-5 with a 3.49 ERA and he is also coming off a start in which he gave up 4 earned runs. The team hasn't had success with him lately though, losing 2 games in a row now with him starting, and the Giants can take advantage of the way the Mets have struggled more on the road this season. The best way to place a bet here is on the Giants to win this game. 

Mets Giants Prediction:  Our MLB Pick for Friday, July 25, 2025 (10:15 pm ET start time) is Giants 3 Mets 2.

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New York Mets: 50-38 (+9.5 units) on the moneyline against NL West opponents. 172-139 (+16.4 units) on the moneyline against right-handed starters. 81-63 (+4.1 units) on the moneyline after 3 or more consecutive home games. 13-6 UNDER against NL West opponents.

San Francisco Giants: 42-44 (-9.3 units) on the moneyline against NL East opponents. 214-213 (-23.6 units) on the moneyline in all games. 115-94 (-7.1 units) on the moneyline in home games. 94-63 UNDER when the money line is -100 to -150.

New York Mets:  B. Waddell (RP) Fifteen Day IL - Hip. D. Nunez (RP) Sixty Day IL - Elbow. J. Winker (LF) Ten Day IL - Back. T. Megill (SP) Sixty Day IL - Elbow. P. Blackburn (SP) Fifteen Day IL - Shoulder. G. Canning (SP) Sixty Day IL - Achilles. J. Siri (CF) Sixty Day IL - Shin. M. Kranick (RP) Fifteen Day IL - Elbow. D. Young (RP) Sixty Day IL - Elbow. A. Minter (RP) Sixty Day IL - Lat. C. Scott (SP) Sixty Day IL - Elbow. N. Madrigal (3B) Sixty Day IL - Shoulder. D. Smith (RP) Sixty Day IL - Elbow.

San Francisco Giants:  E. Miller (RP) Fifteen Day IL - Elbow. C. Koss (2B) Ten Day IL - Hamstring. J. Encarnacion (RF) Ten Day IL - Oblique. T. Murphy (C) Sixty Day IL - Back.

“We’re going to need those guys. We know that they’re going through it. But they’re too good, man. They’re too good of hitters. They’re too good of players. And I’m glad that they were able to come through for us today.” - Carlos Mendoza after his team’s win against the LA Angels in their game on Wednesday.

“We know every time he goes out there guys try extra hard and for whatever reason it just hasn’t worked out. For him to be able to get through five after throwing [40] pitches in the first inning, there’s some toughness involved in that. [There’s] a lot of heat out there. He knows that bullpen-wise we’re beat up, too. To get through the first was huge for him.” - Bob Melvin after his team’s win against the Braves in their game on Wednesday.

Brandon Nimmo (L) LF

Francisco Lindor (S) SS

Juan Soto (L) RF

Pete Alonso (R) 1B

Starling Marte (R) DH

Brett Baty (L) 2B

Mark Vientos (R) 3B

Luis Torrens (R) C

Tyrone Taylor (R) CF

Heliot Ramos (R) LF

Rafael Devers (L) DH

Willy Adames (R) SS

Matt Chapman (R) 3B

Mike Yastrzemski (L) RF

Casey Schmitt (R) 2B

Dominic Smith (L) 1B

Patrick Bailey (S) C

Luis Matos (R) CF

Batting Average:  José Azocar (.278)

Hits:  Pete Alonso (104)

Home Runs:  Juan Soto (24)

RBI:  Pete Alonso (80)

Stolen Bases:  Francisco Lindor (16)

Wins:  Clay Holmes (8)

Saves:  Edwin Díaz (21)

ERA:  Rico Garcia (0.00)

Batting Average:  Heliot Ramos (.267)

Hits:  Heliot Ramos (104)

Home Runs:  Willy Adames (15)

RBI:  Wilmer Flores (59)

Stolen Bases:  Tyler Fitzgerald (9)

Wins:  Robbie Ray (9)

Saves:  Camilo Doval (15)

ERA:  Matt Gage (0.00)

Managers:

New York Mets: Carlos Mendoza (2nd season)

San Francisco Giants: Bob Melvin (2nd season)