Minnesota Twins vs Los Angeles Dodgers Prediction, Preview and Odds - 07/22/2025

by Rod Pearson

Monday, Jul 21, 2025
Game Time: 10:10 pm ET, Tuesday, July 22, 2025
Venue:  Dodger Stadium, Los Angeles, CA 
Where to Watch:  MLBN


Opening Odds at USA Sportsbooks

DraftKings:  Moneyline odds:  Twins +183, Dodgers -227; Over/Under:  8.5 runs
Bet365:  Moneyline odds:  Twins +185, Dodgers -225; Over/Under:  8.5 runs
BetMGM:  Moneyline odds:  Twins +185, Dodgers -225; Over/Under:  8.5 runs

Season Record

Minnesota Twins:  48-51 (3rd place, AL Central)
Los Angeles Dodgers:  58-42 (1st place, NL West)

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Recent Form
Minnesota Twins:  5-5 last 10
Los Angeles Dodgers:  2-8 last 10



Minnesota Twins vs Los Angeles Dodgers Preview and Analysis


The Twins are entering this series off a win and lost their 3-game series against the Colorado Rockies 2-1 in their last series. They enter this game with a 48-51 record overall and have a road record of 20-31. This is the 2nd game of a 3-game series with the Dodgers on Tuesday with the series opener still to be played on Monday. Their offense ranks 16th in the MLB with a .714 OPS. David Festa is their starting pitcher on Monday while Simeon Woods Richardson is making his start in this game on Tuesday. He is 5-4 with a 3.95 ERA this season. His team won 3 of their last 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 ER, 1 HR, and 1 BB with 3 SO on 6 hits through 4.2 IP against the Pittsburgh Pirates.

The Dodgers are entering this series off a loss and got swept in their 3-game series against the Milwaukee Brewers 3-0 in their last series. They enter this game with a 58-42 record overall and have a home record of 33-20. This is the 2nd game of a 3-game series with the Twins on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 3rd in the MLB with a .772 OPS. Shohei Ohtani is their starting pitcher on Monday while Yoshinobu Yamamoto is making his start in this game on Tuesday. He is 8-7 with a 2.59 ERA this season. His team won 3 of their last 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 2 walks with 7 strikeouts on 3 hits through 7 innings pitched against the San Francisco Giants.


Twins vs Dodgers Prediction

The current betting odds have the Dodgers listed as a big favorite in this game according to Draftkings Sportsbook. The Dodgers have looked great in their games this season with their 58-42 record overall which has them right at the top of the NL West with one of the best records in the entire MLB. They have also looked great in their own ballpark this year with their 33-20 home record. Meanwhile, the Twins haven't looked great in their games this season with their 48-51 record overall which has them right in the middle of the AL Central. They have been a terrible road team too with their 20-31 road record. The Dodgers have been in a terrible slump lately as they were just swept by the Brewers in their last series and they are also 2-8 in their last 10 games, but this is a great series for them to bounce back against a weaker opponent. They are going to have Yamamoto on the mound here and he has been one of their best starters this season. He is 8-7 with a 2.50 ERA and hasn't been giving up many runs lately. He is coming off another great start in which he gave up no runs, and the team has had a lot of success with him too, winning 3 of their last 4 games with him starting. Woods Richardson is on the mound for the Twins here and he hasn't looked great this season. He is 5-4 with a 3.95 ERA and has been really up and down this year. He has been better lately with the team winning 3 of his last 4 starts and he only gave up 1 earned run in his last start too, but the Dodgers are going to be desperate to bounce back here and this is still one of the best offenses in the MLB. The best way to place a bet here is on the Dodgers to win this game and on the runline. 

Twins Dodgers Prediction:  Our MLB Pick for Tuesday, July 22, 2025 (10:10 pm ET start time) is Dodgers 5 Twins 1.
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MLB Betting Trends


Minnesota Twins: 220-209 (-37.5 units) on the moneyline in all games. 100-115 (-24.4 units) on the moneyline in road games. 47-73 (-15.9 units) on the moneyline as an underdog of +100 or higher. 12-6 OVER on the road against NL West opponents.

Los Angeles Dodgers: 30-13 (+7 units) on the moneyline against AL Central opponents. 237-134 (+5.6 units) on the moneyline as a favorite of -110 or higher. 81-44 (+13 units) on the moneyline in an inter-league game. 205-150 OVER as a favorite of -110 or higher.

Key Injuries


Minnesota Twins:  B. Ober (SP) Fifteen Day IL - Hip. P. Lopez (SP) Sixty Day IL - Shoulder. L. Keaschall (2B) Sixty Day IL - Forearm.

Los Angeles Dodgers:  F. Freeman (1B) Day To Day - Wrist. M. Kopech (RP) Sixty Day IL - Knee. E. Hernandez (1B) Ten Day IL - Elbow. M. Muncy (3B) Ten Day IL - Knee. R. Sasaki (SP) Sixty Day IL - Shoulder. T. Gonsolin (SP) Sixty Day IL - Elbow. E. Phillips (RP) Sixty Day IL - forearm. B. Snell (SP) Sixty Day IL - Shoulder. B. Treinen (RP) Sixty Day IL - Forearm. K. Hurt (SP) Sixty Day IL - Elbow. B. Graterol (RP) Sixty Day IL - Shoulder. M. Grove (RP) Sixty Day IL - Shoulder. R. Ryan (SP) Sixty Day IL - Elbow. G. Stone (SP) Sixty Day IL - Shoulder.


Notable Quotes


“He looked great. He pitched the way he pitched in the All-Star Game, and he pitched the way he pitched before the All-Star Game. This is the way he pitches. Never surprised to see it, but he was absolutely on point all day long. Gave us a great chance to win with an outing like that. It was a heck of an outing.” - Rocco Baldelli after his team’s win against the Rockies in their game on Sunday.


"He just doesn't come out of games. I didn't know why he was walking toward me. Then hearing him saying that it was his wrist and he can't continue. So yeah, really worried, and typically it's the other way around." - Dave Roberts on Freddie Freeman after his team’s loss against the Brewers in their game on Sunday.


Starting Lineups


Minnesota Twins
Trevor Larnach (L) DH
Willi Castro (S) LF
Carlos Correa (R) SS
Kody Clemens (L) 2B
Ty France (R) 1B
Matt Wallner (L) RF
Harrison Bader (R) CF
Royce Lewis (R) 3B
Christian Vázquez (R) C

Los Angeles Dodgers
Mookie Betts (R) SS
Shohei Ohtani (L) DH
Teoscar Hernández (R) RF
Freddie Freeman (L) 1B
Tommy Edman (S) 3B
Miguel Rojas (R) 2B
Andy Pages (R) CF
Esteury Ruiz (R) LF
Dalton Rushing (L) C

Statistical Leaders


Minnesota Twins
Batting Average:  Luke Keaschall (.368)
Hits:  Byron Buxton (89)
Home Runs:  Byron Buxton (22)
RBI:  Byron Buxton (57)
Stolen Bases:  Byron Buxton (17)
Wins:  Joe Ryan (10)
Saves:  Jhoan Duran (15)
ERA:  Danny Coulombe (0.65)

Los Angeles Dodgers
Batting Average:  Hyeseong Kim (.328)
Hits:  Shohei Ohtani (105)
Home Runs:  Shohei Ohtani (34)
RBI:  Shohei Ohtani (65)
Stolen Bases:  Shohei Ohtani (13)
Wins:  Yoshinobu Yamamoto (8)
Saves:  Tanner Scott (19)
ERA:  Evan Phillips (0.00)

Managers:
Minnesota Twins: Rocco Baldelli (7th season)
Los Angeles Dodgers: Dave Roberts (10th season)


Rod Pearson

About the Author:

Rod Pearson has been a rabid sports fan his entire life.  He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years.  In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective.  Join Rod every day as he breaks down the games to find the best betting value.

All photographic images used for editorial content have been licensed from the Associated Press.

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