Minnesota Twins vs Detroit Tigers Prediction, Preview and Odds - 08/05/2025

Game Time: 6:40 pm ET, Tuesday, August 5, 2025

Venue:  Comerica Park, Detroit, MI 

Where to Watch:  TWINS.tv, FDSD

DraftKings:  Moneyline odds:  Twins +140, Tigers -172; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Twins +140, Tigers -170; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Twins +140, Tigers -170; Over/Under:  8.5 runs

Minnesota Twins:  52-59 (4th place, AL Central)

Detroit Tigers:  65-48 (1st place, AL Central)

Do not miss out on our expert handicapper analysis! Sean Murphy is on a HOT STREAK in the MLB on a 9-3 MLB RUN for +$8,320 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Minnesota Twins:  3-7 last 10

Detroit Tigers:  5-5 last 10

The Twins are entering this series off a win and lost their 3-game series against the Cleveland Guardians 2-1 in their last series. They enter this game with a 52-59 record overall and have a road record of 22-35. This is the 2nd game of a 3-game series with the Tigers on Tuesday with the series opener still to be played on Monday. Their offense ranks 19th in the MLB with a .708 OPS. Rookie pitcher Travis Adams is their starting pitcher on Monday while Zebby Matthews is making his start in this game on Tuesday. He is 2-3 with a 5.67 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 5 ER, 1 HR, and 0 BB with 4 SO on 8 hits through 4.1 IP against the Boston Red Sox.

The Tigers are entering this series off a loss and lost their 3-game series against the Philadelphia Phillies 2-1 in their last series. They enter this game with a 65-48 record overall and have a home record of 36-21. This is the 2nd game of a 3-game series with the Twins on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 8th in the MLB with a .738 OPS. Casey Mize is their starting pitcher on Monday while Chris Paddack is making his start in this game on Tuesday. He is 4-9 with a 4.77 ERA this season. His team lost 3 of their last 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 0 walks with 5 strikeouts on 3 hits through 6 innings pitched against the Arizona Diamondbacks.

The current betting odds have the Tigers listed as a favorite in this game according to Draftkings Sportsbook. The Tigers have looked great in their games this season with their 65-48 record overall which has them right at the top of the AL Central with one of the best records in the entire MLB. They have also looked great in their own ballpark this year with their 36-21 home record. Meanwhile, the Twins haven't looked good in their games this season with their 52-59 record overall which has them right near the bottom of the AL Central. They have also been a terrible road team this year with their 22-35 road record. The Tigers haven't looked great lately as they are only 5-5 in their last 10 games, but the Twins are 3-7 in their last 10 and made a lot of moves trading away players at the deadline. The Tigers don't have the best option on the mound here, but neither do the Twins so the Tigers can take advantage of that at home as a team that is still well in contention. Paddack is on the mound here and he hasn't looked great this season. He is 4-9 with a 4.77 ERA and was terrible on the Twins for most of the season, but he has looked a lot better since coming to the Tigers. He is coming off a great start in which he gave up 1 earned run and the Tigers have given him new life as a starter. He will bring his best effort for the team that traded him away and the Twins don't have a great offense either. The Twins are also going with Matthews in this one and he hasn't looked good this season. He is 2-3 with a 5.67 ERA and has been giving up a lot of runs in his starts. He is coming off another bad start in which he gave up 5 earned runs and the team has lost 2 of their last 3 games with him starting too. The best way to place a bet here is on the Tigers to win this game. 

Twins Tigers Prediction:  Our MLB Pick for Tuesday, August 5, 2025 (6:40 pm ET start time) is Tigers 4 Twins 1.

Don't miss our champion handicappers free picks, best bets, and expert baseball picks today.  And if you enjoyed this Minnesota Twins Detroit Tigers prediction, be sure to drop by every day for our daily MLB projections and previews.

Minnesota Twins: 224-217 (-42.6 units) on the moneyline in all games. 102-119 (-25.2 units) on the moneyline in road games. 49-78 (-17.7 units) on the moneyline as an underdog of +100 or higher. 22-13 UNDER as an underdog of +100 or higher.

Detroit Tigers: 233-212 (+30.5 units) on the moneyline in all games. 112-66 (+15.3 units) on the moneyline as a favorite of -110 or higher. 83-53 (+31 units) on the moneyline against division opponents. 31-21 UNDER as a home favorite of -125 to -175.

Minnesota Twins:  B. Buxton (CF) Ten Day IL - Side Soreness. A. Misiewicz (RP) Fifteen Day IL - Shoulder. D. Festa (SP) Fifteen Day IL - Shoulder. P. Lopez (SP) Sixty Day IL - Shoulder. L. Keaschall (2B) Sixty Day IL - Forearm.

Detroit Tigers:  P. Sewald (RP) Sixty Day IL - Shoulder. P. Meadows (CF) Ten Day IL - Quad. R. Olson (SP) Sixty Day IL - Shoulder. S. Guenther (RP) Sixty Day IL - Hip. S. Gipson-Long (SP) Fifteen Day IL - Neck. J. Jobe (SP) Sixty Day IL - Flexor. J. Foley (RP) Sixty Day IL - Shoulder. A. Cobb (SP) Sixty Day IL - Hip. T. Madden (SP) Sixty Day IL - Shoulder. J. Urquidy (SP) Sixty Day IL - Elbow. A. Lange (RP) Sixty Day IL - Lat.

“He’s going to be looking for that weak contact, and he got a whole bunch of it as the outing went on. That’s what you’re looking for from him, all day long.” - Rocco Baldelli on Jose Urena after his team’s win against the Guardians in their game on Sunday.

“He was good. He held it together and showed a lot of life. He remained calm under pressure and put us in a good position to have a chance.” - A.J. Hinch after his team’s loss against the Phillies in their game on Sunday.

Austin Martin (R) CF

Ryan Jeffers (R) DH

Matt Wallner (L) RF

Royce Lewis (R) 3B

Kody Clemens (L) 1B

Brooks Lee (S) SS

Trevor Larnach (L) LF

Christian Vázquez (R) C

Edouard Julien (L) 2B

Matt Vierling (R) CF

Gleyber Torres (R) 2B

Jahmai Jones (R) DH

Spencer Torkelson (R) 1B

Riley Greene (L) LF

Andy Ibáñez (R) 3B

Dillon Dingler (R) C

Wenceel Pérez (S) RF

Javier Báez (R) SS

Batting Average:  Austin Martin (.400)

Hits:  Byron Buxton (92)

Home Runs:  Byron Buxton (23)

RBI:  Byron Buxton (59)

Stolen Bases:  Byron Buxton (17)

Wins:  Joe Ryan (10)

Saves:  Jhoan Duran (16)

ERA:  Erasmo Ramírez (0.00)

Batting Average:  Brewer Hicklen (.667)

Hits:  Riley Greene (115)

Home Runs:  Riley Greene (26)

RBI:  Riley Greene (84)

Stolen Bases:  Zach McKinstry (17)

Wins:  Tarik Skubal (11)

Saves:  Will Vest (16)

ERA:  Kyle Finnegan (0.00)

Managers:

Minnesota Twins: Rocco Baldelli (7th season)

Detroit Tigers: A.J. Hinch (5th season)