Milwaukee Brewers vs Seattle Mariners Prediction, Preview and Odds - 07/23/2025

Game Time: 3:40 pm ET, Wednesday, July 23, 2025

Venue:  T-Mobile Park, Seattle, WA 

Where to Watch:  FDSWI, ROOT Sports NW

DraftKings:  Moneyline odds:  Brewers +108, Mariners -132; Over/Under:  7.5 runs

Bet365:  Moneyline odds:  Brewers +110, Mariners -130; Over/Under:  7.5 runs

BetMGM:  Moneyline odds:  Brewers +110, Mariners -130; Over/Under:  7.5 runs

Milwaukee Brewers:  60-40 (2nd place, NL Central)

Seattle Mariners:  53-47 (2nd place, AL West)

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Milwaukee Brewers:  10-0 last 10

Seattle Mariners:  5-5 last 10

The Brewers are entering this series off a win and completed the sweep in their 3-game series against the Los Angeles Dodgers 3-0 in their last series. They enter this game with a 60-40 record overall and have a road record of 27-23. This is the series finale of a 3-game series with the Mariners on Wednesday with the 2nd game still to be played on Tuesday. The Brewers won the series opener on Monday. Their offense ranks 18th in the MLB with a .710 OPS. Rookie pitcher Jacob Misiorowski is their starting pitcher on Tuesday while Quinn Priester is making his start in this game on Wednesday. He is 8-2 with a 3.33 ERA this season. His team won their last 9 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 0 ER, 0 HR, and 0 BB with 10 SO on 3 hits through 6 IP against the Los Angeles Dodgers.

The Mariners are entering this series off a loss and won their 3-game series against the Houston Astros 2-1 in their last series. They enter this game with a 53-47 record overall and have a home record of 27-23. This is the 3rd game of a 3-game series with the Brewers on Wednesday with the 2nd game of this series still to be played on Tuesday. The Mariners lost the 1st game of this series on Monday. Their offense ranks 8th in the MLB with a .738 OPS. Logan Gilbert is their starting pitcher on Tuesday while Luis Castillo is making his start in this game on Wednesday. He is 7-5 with a 3.21 ERA this season. His team won their last 5 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 2 walks with 7 strikeouts on 3 hits through 6.2 innings pitched against the Houston Astros.

The current betting odds have the Brewers listed as a slight underdog in this game according to Draftkings Sportsbook. The Mariners have looked good in their games this season with their 53-47 record overall which has them right near the top of the AL West. They have also looked good in their own ballpark this year with their 27-23 home record. Meanwhile, the Brewers have looked really good in their games this season with their 60-40 record overall which has them right near the top of the NL Central with one of the best records in the entire MLB. They have also been a good road team with their 27-23 road record this season. The Mariners won their series against the Astros coming out of the All-Star break, but they have still been cooling off lately as they are only 5-5 in their last 10 games. The Brewers have been red hot though as they are 10-0 in their last 10 games and have won 11 games in a row now. They are going to have Priester on the mound here and he has looked great this season. He is 8-2 with a 3.33 ERA and the team has had a ton of success with him starting lately. He is coming off another great start in which he gave up no runs and the team has won 9 games in a row now with him starting. The Mariners are also going to have a solid starter here with Castillo on the mound. He is 7-5 with a 3.21 ERA and hasn't been giving up many runs lately either. He gave up no runs in his last start too and his team has also had a ton of success with him lately, winning 5 games in a row now with him on the mound. Both of these starters have been great, but the Brewers have all the momentum on their side right now and the hotter offense coming out of the break. The best way to place a bet here is on the Brewers to win this game. 

Brewers Mariners Prediction:  Our MLB Pick for Wednesday, July 23, 2025 (3:40 pm ET start time) is Brewers 2 Mariners 1.

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Milwaukee Brewers: 25-12 (+11 units) on the moneyline against AL West opponents. 246-184 (+43.9 units) on the moneyline in all games. 95-86 (+32.6 units) on the moneyline as an underdog of +100 or higher. 34-20 UNDER when the money line is +125 to -125.

Seattle Mariners: 226-198 (-13.2 units) on the moneyline in all games. 160-117 (-12.2 units) on the moneyline as a favorite of -110 or higher. 161-147 (-16.5 units) on the moneyline against right-handed starters. 8-4 UNDER at home vs. NL teams allowing 4.0 or less runs/game on the season.

Milwaukee Brewers:  J. Bauers (LF) Ten Day IL - Shoulder. S. Frelick (RF) Ten Day IL - Hamstring. R. Hoskins (1B) Ten Day IL - Thumb. G. Mitchell (CF) Sixty Day IL - Oblique. R. Zastryzny (RP) Fifteen Day IL - Ribs. N. Cortes (SP) Sixty Day IL - Elbow. C. Thomas (SP) Sixty Day IL - Elbow. R. Gasser (SP) Sixty Day IL - Elbow.

Seattle Mariners:  B. Miller (SP) Fifteen Day IL - Elbow. C. Snider (RP) Fifteen Day IL - Forearm. G. Santos (RP) Sixty Day IL - Knee. V. Robles (RF) Sixty Day IL - Shoulder. R. Bliss (2B) Sixty Day IL - Biceps.

“Have we done everything we can do in 100 games? Have we played as good as we can all play? So, there’s more to be done. There’s more opportunity. There’s no reason to coast. There’s every reason to know you’re in a fight. When you drop your guard, ‘whack!’” - Pat Murphy after his team’s win against the Mariners in their game on Monday.

“It was great to see Brandyn out there and get a chance to get his feet wet. Obviously, he probably didn’t want to give up the two runs, but I thought he threw the ball pretty well, his sinker was pretty good. Just a couple of bad-luck situations for him.” - Dan Wilson on Brandyn Garcia after his team’s loss against the Brewers in their game on Monday.

Brice Turang (L) 2B

William Contreras (R) C

Christian Yelich (L) DH

Jackson Chourio (R) RF

Isaac Collins (S) LF

Andrew Vaughn (R) 1B

Blake Perkins (S) CF

Anthony Seigler (S) 3B

Joey Ortiz (R) SS

J.P. Crawford (L) SS

Julio Rodríguez (R) CF

Cal Raleigh (S) C

Randy Arozarena (R) LF

Jorge Polanco (S) DH

Luke Raley (L) 1B

Dominic Canzone (L) RF

Ben Williamson (R) 3B

Cole Young (L) 2B

Batting Average:  Andrew Vaughn (.333)

Hits:  Jackson Chourio (112)

Home Runs:  Christian Yelich (19)

RBI:  Christian Yelich (66)

Stolen Bases:  Brice Turang (18)

Wins:  Freddy Peralta (12)

Saves:  Trevor Megill (23)

ERA:  Brandon Woodruff (1.65)

Batting Average:  Dominic Canzone (.311)

Hits:  J.P. Crawford (103)

Home Runs:  Cal Raleigh (38)

RBI:  Cal Raleigh (83)

Stolen Bases:  Julio Rodríguez (19)

Wins:  Bryan Woo (8)

Saves:  Andrés Muñoz (21)

ERA:  Sauryn Lao (0.00)

Managers:

Milwaukee Brewers: Pat Murphy (2nd season)

Seattle Mariners: Dan Wilson (2nd season)