Milwaukee Brewers vs Seattle Mariners Prediction, Preview and Odds - 07/22/2025

Game Time: 9:40 pm ET, Tuesday, July 22, 2025

Venue:  T-Mobile Park, Seattle, WA 

Where to Watch:  MLBN

DraftKings:  Moneyline odds:  Brewers +104, Mariners -126; Over/Under:  7 runs

Bet365:  Moneyline odds:  Brewers +105, Mariners -125; Over/Under:  7 runs

BetMGM:  Moneyline odds:  Brewers +105, Mariners -125; Over/Under:  7 runs

Milwaukee Brewers:  59-40 (2nd place, NL Central)

Seattle Mariners:  53-46 (2nd place, AL West)

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Milwaukee Brewers:  10-0 last 10

Seattle Mariners:  6-4 last 10

The Brewers are entering this series off a win and completed the sweep in their 3-game series against the Los Angeles Dodgers 3-0 in their last series. They enter this game with a 59-40 record overall and have a road record of 26-23. This is the 2nd game of a 3-game series with the Mariners on Tuesday with the series opener still to be played on Monday. Their offense ranks 18th in the MLB with a .710 OPS. Brandon Woodruff is their starting pitcher on Monday while rookie pitcher Jacob Misiorowski is making his start in this game on Tuesday. He is 4-1 with a 2.81 ERA this season. His team won 4 of their last 5 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 ER, 1 HR, and 1 BB with 12 SO on 4 hits through 6 IP against the Los Angeles Dodgers.

The Mariners are entering this series off a loss and won their 3-game series against the Houston Astros 2-1 in their last series. They enter this game with a 53-46 record overall and have a home record of 27-22. This is the 2nd game of a 3-game series with the Brewers on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 6th in the MLB with a .741 OPS. George Kirby is their starting pitcher on Monday while Logan Gilbert is making his start in this game on Tuesday. He is 2-3 with a 3.39 ERA this season. His team won 4 of their last 5 games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 2 walks with 9 strikeouts on 6 hits through 5.1 innings pitched against the Detroit Tigers.

The current betting odds have the Mariners listed as a slight favorite in this game according to Draftkings Sportsbook. The Mariners have looked good in their games this season with their 53-46 record overall which has them right near the top of the AL West. They have also looked good in their own ballpark this year with their 27-22 home record. Meanwhile, the Brewers have looked really good in their games this season with their 59-40 record overall which has them right near the top of the NL Central with one of the best records in the entire MLB. They have also been a good road team with their 26-23 road record this season. The Brewers have been red hot lately as they just swept the Dodgers in their last series and have won 10 games in a row now, but the Mariners are also coming off a series win over the Astros and have been hot themselves lately, going 6-4 in their last 10 games. Gilbert is on the mound for the Mariners in this one and he has looked great this season. He is 2-3 with a 3.39 ERA and hasn't been giving up many runs lately. He is coming off another great start in which he gave up no runs and the team has had a ton of success with him this season, winning 4 of their last 5 games with him starting too. Misiorowski is on the mound for the Brewers in this one and he has also looked great this season. He is 4-1 with a 2.81 ERA and hasn't been giving up many runs lately. He gave up 1 earned run in his last start and the team has won 4 of their last 5 games with him starting too, but he has also had just the 5 starts in the MLB. He is still in his rookie year and as hot as the Brewers have been lately, they are going to start cooling off, especially after sweeping the Dodgers, and Gilbert has been a great home starter all year so he gives a slight edge to the Mariners in this one. The best way to place a bet here is on the Mariners to win this game. 

Brewers Mariners Prediction:  Our MLB Pick for Tuesday, July 22, 2025 (9:40 pm ET start time) is Mariners 2 Brewers 1.

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Milwaukee Brewers: 24-12 (+9.8 units) on the moneyline against AL West opponents. 245-184 (+42.8 units) on the moneyline in all games. 94-86 (+31.5 units) on the moneyline as an underdog of +100 or higher. 11-6 UNDER on the road when the total is 7 or less.

Seattle Mariners: 226-197 (-12 units) on the moneyline in all games. 160-116 (-11 units) on the moneyline as a favorite of -110 or higher. 161-146 (-15.2 units) on the moneyline against right-handed starters. 7-4 UNDER at home vs. NL teams allowing 4.0 or less runs/game on the season.

Milwaukee Brewers:  J. Bauers (LF) Ten Day IL - Shoulder. S. Frelick (RF) Ten Day IL - Hamstring. R. Hoskins (1B) Ten Day IL - Thumb. G. Mitchell (CF) Sixty Day IL - Oblique. R. Zastryzny (RP) Fifteen Day IL - Ribs. N. Cortes (SP) Sixty Day IL - Elbow. C. Thomas (SP) Sixty Day IL - Elbow. R. Gasser (SP) Sixty Day IL - Elbow.

Seattle Mariners:  B. Miller (SP) Fifteen Day IL - Elbow. C. Snider (RP) Fifteen Day IL - Forearm. G. Santos (RP) Sixty Day IL - Knee. V. Robles (RF) Sixty Day IL - Shoulder. R. Bliss (2B) Sixty Day IL - Biceps.

"It shows you how hard our game is. You do everything perfect and you hit a line drive right where you need to. That’s the way baseball is.” - Pat Murphy after his team’s win against the LA Dodgers in their game on Sunday.

“It sucks. Frustrating, to say the least, especially because I just feel like a lot of it's on me.” - Bryan Woo after their loss against the Astros in their game on Sunday.

Jackson Chourio (R) RF

William Contreras (R) DH

Andrew Vaughn (R) 1B

Isaac Collins (S) LF

Caleb Durbin (R) 3B

Blake Perkins (S) CF

Andruw Monasterio (R) 2B

Joey Ortiz (R) SS

Eric Haase (R) C

J.P. Crawford (L) SS

Julio Rodríguez (R) CF

Cal Raleigh (S) DH

Randy Arozarena (R) LF

Jorge Polanco (S) 2B

Luke Raley (L) 1B

Mitch Garver (R) C

Dominic Canzone (L) RF

Miles Mastrobuoni (L) 3B

Batting Average:  Andrew Vaughn (.391)

Hits:  Jackson Chourio (110)

Home Runs:  Christian Yelich (19)

RBI:  Christian Yelich (65)

Stolen Bases:  Brice Turang (18)

Wins:  Freddy Peralta (12)

Saves:  Trevor Megill (23)

ERA:  Logan Henderson (1.71)

Batting Average:  Dominic Canzone (.317)

Hits:  J.P. Crawford (103)

Home Runs:  Cal Raleigh (38)

RBI:  Cal Raleigh (83)

Stolen Bases:  Julio Rodríguez (19)

Wins:  Bryan Woo (8)

Saves:  Andrés Muñoz (21)

ERA:  Sauryn Lao (0.00)

Managers:

Milwaukee Brewers: Pat Murphy (2nd season)

Seattle Mariners: Dan Wilson (2nd season)