Miami Marlins vs St Louis Cardinals Prediction, Preview and Odds - 07/30/2025

Game Time: 7:45 pm ET, Wednesday, July 30, 2025

Venue:  Busch Stadium, St. Louis, MO

Where to Watch:  FDSFL, FDSMW

DraftKings:  Moneyline odds:  Marlins +124, Cardinals -151; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Marlins +125, Cardinals -150; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Marlins +125, Cardinals -150; Over/Under:  8.5 runs

Miami Marlins:  50-55 (3rd place, NL East)

St Louis Cardinals:  55-53 (4th place, NL Central)

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Miami Marlins:  6-4 last 10

St Louis Cardinals:  4-6 last 10

The Marlins are entering this series off a loss and won their 3-game series against the Milwaukee Brewers 2-1 in their last series. They enter this game with a 50-55 record overall and have a road record of 26-26. This is the series finale of a 3-game series with the Cardinals on Wednesday with the 2nd game still to be played on Tuesday. The Marlins lost the series opener on Monday. Their offense ranks 20th in the MLB with a .708 OPS. Sandy Alcantara is their starting pitcher on Tuesday while Cal Quantrill is making his start in this game on Wednesday. He is 3-8 with a 5.05 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 ER, 1 HR, and 0 BB with 4 SO on 3 hits through 5 IP against the Milwaukee Brewers.

The Cardinals are entering this series off a loss and split their 4-game series against the San Diego Padres 2-2 in their last series. They enter this game with a 55-53 record overall and have a home record of 32-22. This is the 3rd game of a 3-game series with the Marlins on Wednesday with the 2nd game of this series still to be played on Tuesday. The Cardinals won the 1st game of this series on Monday. Their offense ranks 14th in the MLB with a .714 OPS. Sonny Gray is their starting pitcher on Tuesday while Miles Mikolas is making his start in this game on Wednesday. He is 6-7 with a 4.94 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 0 walks with 1 strikeout on 7 hits through 5 innings pitched against the San Diego Padres.

The current betting odds have the Cardinals listed as a favorite in this game according to Draftkings Sportsbook. The Cardinals have looked good in their games this season with their 55-53 record overall, but that record still has them near the bottom of the NL Central in a competitive division. They have looked a lot better in their own ballpark though with their 32-22 home record this season. Meanwhile, the Marlins haven't looked great in their games this season with their 50-55 record overall which has them right in the middle of the NL East. They haven't been a great road team either with their 26-26 road record this year. They have been the hotter team lately as they are 6-4 in their last 10 games and the Cardinals are 4-6, but the Cardinals are starting to play better now and can take advantage of this pitching matchup at home. The Cardinals are going with Mikolas in this one and he hasn't looked great this season. He is 6-7 with a 4.94 ERA, but he has looked a lot better lately. The team has had more success lately as they have won 2 of their last 3 games with him starting and he is coming off a great start in which he gave up no runs. Quantrill is on the mound for the Marlins in this one and he hasn't looked great this season. He is 3-8 with a 5.05 ERA and has been giving up a lot of runs lately. He only gave up 1 earned run in his last start and the team has won 2 games in a row now with him starting too, but that hasn't been a common theme for him this year and he isn't going to look as good on the road here where the Cardinals have looked like a different team. The best way to place a bet here is on the Cardinals to win this game. 

Marlins Cardinals Prediction:  Our MLB Pick for Wednesday, July 30, 2025 (7:45 pm ET start time) is Cardinals 9 Marlins 5.

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Miami Marlins: 196-234 (+7.9 units) on the moneyline in all games. 96-119 (+21.1 units) on the moneyline in road games. 139-180 (+23.7 units) on the moneyline as an underdog of +100 or higher. 25-18 UNDER on the road against NL Central opponents.

St Louis Cardinals: 208-224 (-30.5 units) on the moneyline in all games. 111-105 (-17.8 units) on the moneyline in home games. 98-101 (-42.9 units) on the moneyline as a favorite of -110 or higher. 9-5 UNDER vs. a starting pitcher whose winning percentage is worse than 30%.

Miami Marlins:  K. Stowers (LF) Day To Day - Illness. D. Hill (LF) Ten Day IL - Finger. J. Tinoco (RP) Sixty Day IL - Forearm. C. Norby (3B) Ten Day IL - Wrist. M. Meyer (SP) Sixty Day IL - Hip. R. Weathers (SP) Sixty Day IL - Lat. G. Conine (LF) Sixty Day IL - Arm. A. Nardi (RP) Sixty Day IL - Back. B. Garrett (SP) Sixty Day IL - Elbow.

St Louis Cardinals:  N. Gorman (2B) Ten Day IL - Back. L. Nootbaar (LF) Ten Day IL - Ribs. Z. Thompson (RP) Sixty Day IL - Lat.

“I think we're going to continue to try to win as many games as we can, and that'd be right now and that'd be moving through the course of the season. With the group here, we have to keep getting better and we have to keep getting better organizationally. We have a lot of room to grow, to put ourselves in what we believe are going to be, year after year, a position to be able to compete and contend.” - Clayton McCullough on the upcoming trade deadline.

“I had some hard-hit balls at guys and I feel like that’s just kind of evening out with what’s been going on over the last few weeks. But I stayed on the attack, commanded the inside part of the plate and I kept the offspeed down.” - Andre Pallante after their win against the Marlins in their game on Monday.

Xavier Edwards (S) 2B

Jesús Sánchez (L) RF

Agustín Ramírez (R) C

Heriberto Hernandez (R) LF

Otto Lopez (R) SS

Liam Hicks (L) DH

Eric Wagaman (R) 1B

Graham Pauley (L) 3B

Dane Myers (R) CF

Brendan Donovan (L) 2B

Iván Herrera (R) LF

Alec Burleson (L) DH

Willson Contreras (R) 1B

Masyn Winn (R) SS

Jordan Walker (R) RF

Yohel Pozo (R) C

Thomas Saggese (R) 3B

Victor Scott II (L) CF

Batting Average:  Rob Brantly (.429)

Hits:  Xavier Edwards (105)

Home Runs:  Kyle Stowers (23)

RBI:  Kyle Stowers (63)

Stolen Bases:  Xavier Edwards (17)

Wins:  Ronny Henriquez (6)

Saves:  Calvin Faucher (9)

ERA:  Freddy Tarnok (0.00)

Batting Average:  José Fermín (.350)

Hits:  Brendan Donovan (110)

Home Runs:  Willson Contreras (14)

RBI:  Willson Contreras (61)

Stolen Bases:  Victor Scott (27)

Wins:  Sonny Gray (10)

Saves:  Ryan Helsley (21)

ERA:  Riley O'Brien (1.75)

Managers:

Miami Marlins: Clayton McCullough (1st season)

St Louis Cardinals: Oliver Marmol (4th season)