Kansas City Royals vs Boston Red Sox Prediction, Preview and Odds - 08/06/2025

Game Time: 7:10 pm ET, Wednesday, August 6, 2025

Venue:  Fenway Park, Boston, MA

Where to Watch:  FDSKC, NESN

DraftKings:  Moneyline odds:  Royals +123, Red Sox -150; Over/Under:  9.5 runs

Bet365:  Moneyline odds:  Royals +125, Red Sox -150; Over/Under:  9.5 runs

BetMGM:  Moneyline odds:  Royals +125, Red Sox -150; Over/Under:  9.5 runs

Kansas City Royals:  56-57 (3rd place, AL Central)

Boston Red Sox:  63-51 (2nd place, AL East)

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Kansas City Royals:  6-4 last 10

Boston Red Sox:  8-2 last 10

The Royals are entering this series off a win and won their 3-game series against the Toronto Blue Jays 2-1 in their last series. They enter this game with a 56-57 record overall and have a road record of 28-29. This is the series finale of a 3-game series with the Red Sox on Wednesday with the 2nd game still to be played on Tuesday. The Royals lost the series opener on Monday. Their offense ranks 25th in the MLB with a .687 OPS. Rookie pitcher Ryan Bergert is their starting pitcher on Tuesday while Michael Wacha is making his start in this game on Wednesday. He is 5-9 with a 3.38 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 ER, 1 HR, and 0 BB with 5 SO on 3 hits through 8 IP against the Toronto Blue Jays.

The Red Sox are entering this series off a win and completed the sweep in their 3-game series against the Houston Astros 3-0 in their last series. They enter this game with a 63-51 record overall and have a home record of 38-21. This is the 3rd game of a 3-game series with the Royals on Wednesday with the 2nd game of this series still to be played on Tuesday. The Red Sox won the 1st game of this series on Monday. Their offense ranks 5th in the MLB with a .755 OPS. Garrett Crochet is their starting pitcher on Tuesday while Dustin May is making his start in this game on Wednesday. He is 6-7 with a 4.85 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 4 earned runs, 1 homer, and 0 walks with 5 strikeouts on 5 hits through 5 innings pitched against the Boston Red Sox.

The current betting odds have the Royals listed as an underdog in this game according to Draftkings Sportsbook. The Red Sox have looked good in their games this season with their 63-51 record overall which has them right near the top of the AL East. They have also looked great in their own ballpark this year with their 38-21 home record. Meanwhile, the Royals haven't looked great in their games this season with their 56-57 record overall which has them right in the middle of the AL Central. They haven't been a great road team either with their 28-29 road record this season. The Red Sox have been red hot lately as they are 8-2 in their last 10 games, but the Royals have also been hot as they are 6-4 in their last 10 and they do have the better pitching matchup here too. The Royals are going with Wacha in this one and he hasn't been bad this season. He is 5-9 with a 3.38 ERA and hasn't been giving up many runs all year even though he has been racking up losses. The team has had more success with him lately though, winning 2 games in a row now with him on the mound, and he is also coming off a great start in which he only gave up 1 earned run. The Red Sox are going with May in this one and they acquired him recently through a trade, but he hasn't been having a great season. He is 6-7 with a 4.85 ERA and has been giving up quite a few runs this year while also racking up losses. His team hasn't had the same success with him lately either, losing 2 of their last 3 games with him starting, and he is coming off a bad start in which he gave up 4 earned runs, something that has been a common theme for him. The best way to place a bet here is on the Royals to win this game. 

Royals Red Sox Prediction:  Our MLB Pick for Wednesday, August 6, 2025 (7:10 pm ET start time) is Royals 6 Red Sox 2.

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Kansas City Royals: 36-60 (-13.9 units) on the moneyline against AL East opponents. 200-243 (-15.7 units) on the moneyline in all games. 113-173 (-12.3 units) on the moneyline as an underdog of +100 or higher. 28-18 UNDER on the road against AL East opponents.

Boston Red Sox: 161-155 (+10.6 units) on the moneyline vs. a team with a good bullpen whose WHIP is 1.350 or better. 81-74 (+12.6 units) on the moneyline vs. an AL starting pitcher whose WHIP is 1.300 or better. 69-54 (+23.4 units) on the moneyline vs. an AL starting pitcher whose ERA is 3.70 or better. 43-27 UNDER as a home favorite of -125 to -175.

Kansas City Royals:  S. Cruz (RP) Fifteen Day IL - Shoulder. K. Bubic (SP) Sixty Day IL - Rotator Cuff. J. Caglianone (RF) Ten Day IL - Hamstring. M. Lorenzen (SP) Fifteen Day IL - Oblique. M. Canha (LF) Ten Day IL - Elbow. M. Massey (2B) Ten Day IL - Ankle. C. Ragans (SP) Sixty Day IL - Rotator Cuff. J. McArthur (RP) Sixty Day IL - Elbow. A. Marsh (SP) Sixty Day IL - Shoulder.

Boston Red Sox:  R. Anthony (RF) Day To Day - Back. L. Guerrero (RP) Sixty Day IL - Elbow. T. Houck (SP) Sixty Day IL - Flexor. H. Dobbins (SP) Sixty Day IL - ACL. M. Mayer (3B) Ten Day IL - Wrist. L. Hendriks (RP) Sixty Day IL - Hip. J. Slaten (RP) Sixty Day IL - Shoulder. J. Winckowski (RP) Sixty Day IL - Elbow. T. Casas (1B) Sixty Day IL - Knee. K. Crawford (SP) Sixty Day IL - Knee. P. Sandoval (SP) Sixty Day IL - Elbow.

“You got to understand the game situation at that point. He’s trying to be aggressive. Probably got a little carried away, knowing there were two outs. Normally you take chances with two outs, but when you’re down by three and you’re getting the go-ahead run to the plate right there, you got to stay at third.” - Matt Quatraro after his team’s loss against the Red Sox in their game on Monday.

“Jarren stayed on a breaking ball the first at-bat and didn’t miss it. I do believe our lefties can hit lefties. It just happens that we’ve got some righties [in Romy Gonzalez and Rob Refsnyder that] mash lefties. We have to play our best lineup up there. We've been doing that.” - Alex Cora after his team’s win against the Royals in their game on Monday.

Jonathan India (R) 2B

Bobby Witt Jr. (R) SS

Vinnie Pasquantino (L) 1B

Maikel Garcia (R) 3B

Salvador Perez (R) C

Mike Yastrzemski (L) RF

Adam Frazier (L) DH

John Rave (L) LF

Kyle Isbel (L) CF

Romy Gonzalez (R) 2B

Alex Bregman (R) 3B

Wilyer Abreu (L) RF

Rob Refsnyder (R) DH

Trevor Story (R) SS

Ceddanne Rafaela (R) CF

Jarren Duran (L) LF

Abraham Toro (S) 1B

Connor Wong (R) C

Batting Average:  Luke Maile (.364)

Hits:  Bobby Witt (127)

Home Runs:  Salvador Perez (20)

RBI:  Vinnie Pasquantino (67)

Stolen Bases:  Bobby Witt (29)

Wins:  Kris Bubic (8)

Saves:  Carlos Estévez (28)

ERA:  Hunter Harvey (0.00)

Batting Average:  Alex Bregman (.297)

Hits:  Jarren Duran (118)

Home Runs:  Wilyer Abreu (20)

RBI:  Trevor Story (69)

Stolen Bases:  Trevor Story (19)

Wins:  Garrett Crochet (12)

Saves:  Aroldis Chapman (21)

ERA:  Nick Burdi (0.00)

Managers:

Kansas City Royals: Matt Quatraro (3rd season)

Boston Red Sox: Álex Cora (5th season)