Indiana Pacers vs New York Knicks Prediction, Preview and Odds - 05/21/2025

Game Time: 8:00 pm ET, Wednesday, May 21, 2025

Venue:  Madison Square Garden, New York, NY

Where to Watch:  TNT, MAX

DraftKings:  Point Spread:  Pacers +4, Knicks -4; Over/Under:  223 points

Bet365:  Point Spread:  Pacers +4.5, Knicks -4.5; Over/Under:  223 points

BetMGM:  Point Spread:  Pacers +4.5, Knicks -4.5; Over/Under:  222.5 points

Indiana Pacers:  50-32 (2nd place, Central Division)

New York Knicks:  51-31 (2nd place, Atlantic Division)

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Indiana Pacers:  8-2 last 10

New York Knicks:  7-3 last 10

The Pacers are entering the playoffs with a 50-32 record overall this season and they were 20-20 in their road games where they will be in this game. They are entering this game on a 2 game winning streak with wins coming against the Cleveland Cavaliers twice in a row. Tyrese Haliburton led the team in points in that game with 31 while Pascal Siakam was next on the team with 21 points. Tyrese Haliburton led the team in assists in that game with 8 while Aaron Nesmith led the team in rebounds with 13. They were 50% from the field, 42.9% from 3-point range, and 77.3% from the free throw line with their shots in that game. Their offense is averaging 117.4 PPG and their defense is allowing their opponents to average 115.1 PPG against them. The Pacers have an ATS record of 43-46-3 this season and their O/U record is 49-41-2.

The Knicks are entering the playoffs with a 51-31 record overall this season and they were 27-14 in their home games where they will be in this game. They are entering this game off a win against the Boston Celtics. OG Anunoby and Jalen Brunson each led the team in points in that game with 23 while Mikal Bridges was next on the team with 22 points. Josh Hart led the team in assists in that game with 11 while Karl-Anthony Towns led the team in rebounds with 12. They were 46.2% from the field, 35.6% from 3-point range, and 90.5% from the free throw line with their shots in that game. Their offense is averaging 115.8 PPG and their defense is allowing their opponents to average 111.7 PPG against them. The Knicks have an ATS record of 48-45-1 this season and their O/U record is 47-45-2.

The current betting odds have the Knicks listed as a 4 point favorite in this game according to Draftkings Sportsbook. This is game 1 of a 7 game series between the 3rd seeded Knicks and the 4th seeded Pacers for the Eastern Conference Finals of the NBA playoffs. The Pacers are coming off a 4-1 series win over the Cavaliers in the last round and the Knicks are coming off a 4-2 series win over the Celtics in the last round. The Pacers managed to kick out the number 1 seed in the East who was one of the best teams in the NBA all season, but the Knicks kicked out the defending champions in 6 games and they are going to be carrying over some momentum from that series win. The Pacers have been great in the playoffs so far as they won both of their series' in 5 games and even won all 3 road games in the last series against the Cavaliers, but the Knicks have also looked great in the playoffs and they expelled a lot of demons with that win over the Celtics, a team they hadn't won a single game against all throughout the regular season. The Knicks are going to have the home advantage in this series and they will be prepared for the Pacers having a strong start like they have done in the last 2 rounds. The Knicks were also a team that struggled a lot against better opponents all season, but they have now destroyed that narrative in these playoffs, and the Pacers weren't one of those teams that gave them trouble in the regular season either. The Pacers also kicked the Knicks out of the playoffs last season right before the Eastern Conference Finals so now that they are meeting again, the Knicks are going to come out strong to get some revenge with a strong start to the series at home. The best way to place a bet here is on the Knicks to cover the spread in this game. 

Pacers Knicks Prediction:  Our NBA Pick for Wednesday, May 21, 2025 (8:00 pm ET start time) is Knicks 120 Pacers 114.

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Indiana Pacers: 20-12 ATS in a road game where the total is 220 to 229.5. 12-3 ATS when playing with 3 or more days rest. 92-57 ATS versus good 3 point shooting teams - making 36% of their attempts or more. 27-16 OVER when playing against a good team (Win Pct. 60% to 70%).

New York Knicks: 14-24 ATS off a win against a division rival. 4-8 ATS at home against Central division opponents. 10-17 ATS at home when playing against a team with a winning record. 10-3 OVER vs. poor rebounding teams - outrebounded by opponents by 3+ per game.

Indiana Pacers:  I. Jackson (C) Out For Season - Calf.

New York Knicks:  None.

“I have to give our guys credit, they earned this. This was one of the best teams in the league. I’m sorry their season had to end like this. They had the perfect season, and we came along and were hot at the right time." - Rick Carlisle after his team’s win against the Cavaliers in game 5 of that series on Tuesday.

“It’s a great win. We advance .You look at that, but you also understand you have to get ready for the next series. The Pacers are a terrific team and we’re going to have to be ready.” - Tom Thibodeau after his team’s win against the Celtics in game 6 of that series on Friday.

PG Tyrese Haliburton

SG Andrew Nembhard

SF Aaron Nesmith

PF Pascal Siakam

C Myles Turner

PG Jalen Brunson

SG Mikal Bridges

SF Josh Hart

PF OG Anunoby

C Karl-Anthony Towns

PPG: P. Siakam (20.2)

APG: T. Haliburton (9.2)

Reb/G: P. Siakam (6.9)

PPG: J. Brunson (26)

APG: J. Brunson (7.3)

Reb/G: K. Towns (12.8)

Coaches:

Indiana Pacers: Rick Carlisle (4th season)

New York Knicks: Tom Thibodeau (5th season)