Houston Astros vs Boston Red Sox Prediction, Preview and Odds - 08/02/2025

Game Time: 4:10 pm ET, Saturday, August 2, 2025

Venue:  Fenway Park, Boston, MA

Where to Watch:  SCHN, NESN

DraftKings:  Moneyline odds:  Astros +104, Red Sox -126; Over/Under:  9.5 runs

Bet365:  Moneyline odds:  Astros +105, Red Sox -125; Over/Under:  9.5 runs

BetMGM:  Moneyline odds:  Astros +105, Red Sox -125; Over/Under:  9.5 runs

Houston Astros:  62-47 (1st place, AL West)

Boston Red Sox:  59-51 (3rd place, AL East)

Do not miss out on our expert handicapper analysis! Nelly’s Sports is on a HOT STREAK in the MLB on a 6-1 MLB RUN for +$5,020 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Houston Astros:  5-5 last 10

Boston Red Sox:  6-4 last 10

The Astros are entering this series off a win and won their 3-game series against the Washington Nationals 2-1 in their last series. They enter this game with a 62-47 record overall and have a road record of 27-23. This is the 2nd game of a 3-game series with the Red Sox on Saturday with the series opener still to be played on Friday. Their offense ranks 12th in the MLB with a .727 OPS. Hunter Brown is their starting pitcher on Friday while rookie pitcher Colton Gordon is making his start in this game on Saturday. He is 4-3 with a 4.74 ERA this season. His team lost 3 of their last 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 4 ER, 2 HR, and 0 BB with 6 SO on 6 hits through 5 IP against the Athletics.

The Red Sox are entering this series off a win and won their 3-game series against the Minnesota Twins 2-1 in their last series. They enter this game with a 59-51 record overall and have a home record of 34-21. This is the 2nd game of a 3-game series with the Astros on Saturday with the 1st game of this series still to be played on Friday. Their offense ranks 5th in the MLB with a .755 OPS. Cooper Criswell is their starting pitcher on Friday while Walker Buehler is making his start in this game on Saturday. He is 6-6 with a 5.72 ERA this season. His team won 3 of their last 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 3 earned runs, 1 homer, and 5 walks with 4 strikeouts on 4 hits through 4.2 innings pitched against the Los Angeles Dodgers.

The current betting odds have the Red Sox listed as a slight favorite in this game according to Draftkings Sportsbook. The Astros have looked great in their games this season with their 62-47 record overall which has them right at the top of the AL West with one of the best records in the entire MLB. They have also been a good road team this year with their 27-23 road record. Meanwhile, the Red Sox have looked good in their games this season with their 59-51 record overall which has them right in the middle of the AL East. They have looked a lot better in their own ballpark this year with their 34-21 home record. The Astros were rolling into the All-Star break, but now they are only 5-5 in their last 10 games while the Red Sox are 6-4. The Red Sox did cool off coming out of the All-Star break, but now they are getting hot again and can take advantage of this pitching matchup. Gordon is on the mound for the Astros in this one and he hasn't looked great this season. He is 4-3 with a 4.74 ERA and has been giving up quite a few runs lately. He is coming off a bad start in which he gave up 4 earned runs and the team hasn't been great with him lately either, losing 3 of the last 4 games he started in. Buehler is on the mound for the Red Sox in this one and he hasn't looked great this season either. He is 6-6 with a 5.72 ERA, but he has looked better lately. He only gave up 3 earned runs in his last start which is an improvement for the way he has pitched this season, and his team has won 3 of the last 4 games he started in too. The Red Sox will play better in their own ballpark here and Buehler is still the more reliable starter since Gordon is still an inexperienced rookie. The best way to place a bet here is on the Red Sox to win this game. 

Astros Red Sox Prediction:  Our MLB Pick for Saturday, August 2, 2025 (4:10 pm ET start time) is Red Sox 8 Astros 6.

Don't miss our champion handicappers free picks, best bets, and expert baseball picks today.  And if you enjoyed this Houston Astros Boston Red Sox prediction, be sure to drop by every day for our daily MLB projections and previews.

Houston Astros: 126-90 (+30.4 units) on the moneyline in road games. 79-59 (+14 units) on the moneyline vs. teams outscoring opp by 0.5 or more runs/game on the season. 44-28 (+11.9 units) on the moneyline vs. AL teams scoring 4.9 or more runs/game on the season. 44-25 OVER vs. AL teams scoring 4.9 or more runs/game on the season.

Boston Red Sox: 217-216 (-15.2 units) on the moneyline in all games. 110-106 (-20.2 units) on the moneyline in home games. 117-98 (-20.6 units) on the moneyline as a favorite of -110 or higher. 7-3 OVER at home vs. a starting pitcher whose gives up 1 or more HR's/start.

Houston Astros:  B. Walter (RP) Fifteen Day IL - Elbow. L. McCullers Jr. (SP) Fifteen Day IL - Finger. I. Paredes (3B) Ten Day IL - Hamstring. B. Rodgers (2B) Sixty Day IL - Oblique. J. Meyers (CF) Ten Day IL - Calf. Z. Dezenzo (RF) Sixty Day IL - Hand. Y. Alvarez (LF) Sixty Day IL - Hand. J. Pena (SS) Ten Day IL - Rib. S. Dubin (RP) Fifteen Day IL - Forearm. P. Leon (RF) Sixty Day IL - Knee. S. Arrighetti (SP) Sixty Day IL - Thumb. R. Blanco (SP) Sixty Day IL - Elbow. H. Wesneski (RP) Sixty Day IL - Elbow. L. Garcia (SP) Sixty Day IL - Elbow. C. Javier (SP) Sixty Day IL - Elbow. J. France (SP) Sixty Day IL - Shoulder.

Boston Red Sox:  H. Dobbins (SP) Sixty Day IL - ACL. M. Mayer (3B) Ten Day IL - Wrist. N. Burdi (RP) Sixty Day IL - Knee. L. Hendriks (RP) Sixty Day IL - Hip. Z. Kelly (RP) Fifteen Day IL - Oblique. L. Guerrero (RP) Fifteen Day IL - Elbow. J. Slaten (RP) Sixty Day IL - Shoulder. J. Winckowski (RP) Sixty Day IL - Elbow. T. Casas (1B) Sixty Day IL - Knee. K. Crawford (SP) Sixty Day IL - Knee. T. Houck (SP) Sixty Day IL - Flexor. P. Sandoval (SP) Sixty Day IL - Elbow.

“We were going through a stretch there where things were not going our way, but our guys are going to push and we figured out a way to score runs. The quality of at-bats were there back to back days. Off day tomorrow, which this group needs, and get ready for a nice series in Boston.” - Joe Espada after his team’s win against the Nationals in their game on Wednesday.

“We came here against a team that people thought that we needed to beat, and we played good baseball. Tomorrow’s an off-day and let's see where we’re at [roster-wise] on Friday.” - Alex Cora after his team’s win against the Twins in their game on Wednesday.

Jose Altuve (R) 2B

Yainer Diaz (R) C

Christian Walker (R) DH

Cam Smith (R) RF

Victor Caratini (S) 1B

Mauricio Dubón (R) 3B

Cooper Hummel (S) LF

Chas McCormick (R) CF

Zack Short (R) SS

Roman Anthony (L) LF

Abraham Toro (S) 3B

Jarren Duran (L) CF

Trevor Story (R) SS

Wilyer Abreu (L) RF

Romy Gonzalez (R) 1B

Masataka Yoshida (L) DH

Ceddanne Rafaela (R) 2B

Connor Wong (R) C

Batting Average:  Jeremy Peña (.322)

Hits:  Jose Altuve (114)

Home Runs:  Isaac Paredes (19)

RBI:  Jose Altuve (57)

Stolen Bases:  Jeremy Peña (15)

Wins:  Framber Valdez (11)

Saves:  Josh Hader (28)

ERA:  Shawn Dubin (1.33)

Batting Average:  Alex Bregman (.298)

Hits:  Jarren Duran (116)

Home Runs:  Wilyer Abreu (20)

RBI:  Trevor Story (65)

Stolen Bases:  Jarren Duran (18)

Wins:  Garrett Crochet (12)

Saves:  Aroldis Chapman (19)

ERA:  Nick Burdi (0.00)

Managers:

Houston Astros: Joe Espada (2nd season)

Boston Red Sox: Álex Cora (5th season)