Cleveland Guardians vs New York Mets Prediction, Preview and Odds - 08/06/2025

Game Time: 1:10 pm ET, Wednesday, August 6, 2025

Venue:  Citi Field, Flushing, NY 

Where to Watch:  MLBN

DraftKings:  Moneyline odds:  Guardians +144, Mets -176; Over/Under:  8 runs

Bet365:  Moneyline odds:  Guardians +145, Mets -175; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Guardians +145, Mets -175; Over/Under:  8 runs

Cleveland Guardians:  57-55 (2nd place, AL Central)

New York Mets:  63-50 (2nd place, NL East)

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Cleveland Guardians:  6-4 last 10

New York Mets:  4-6 last 10

The Guardians are entering this series off a loss and won their 3-game series against the Minnesota Twins 2-1 in their last series. They enter this game with a 57-55 record overall and have a road record of 28-28. This is the series finale of a 3-game series with the Mets on Wednesday with the 2nd game still to be played on Tuesday. The Guardians won the series opener on Monday. Their offense ranks 27th in the MLB with a .678 OPS. Logan Allen is their starting pitcher on Tuesday while Gavin Williams is making his start in this game on Wednesday. He is 6-4 with a 3.33 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 0 ER, 0 HR, and 2 BB with 8 SO on 4 hits through 6 IP against the Minnesota Twins.

The Mets are entering this series off a loss and lost their 3-game series against the San Francisco Giants 2-1 in their last series. They enter this game with a 63-50 record overall and have a home record of 38-19. This is the 3rd game of a 3-game series with the Guardians on Wednesday with the 2nd game of this series still to be played on Tuesday. The Mets lost the 1st game of this series on Monday. Their offense ranks 11th in the MLB with a .728 OPS. Clay Holmes is their starting pitcher on Tuesday while David Peterson is making his start in this game on Wednesday. He is 7-4 with a 2.83 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 0 homers, and 2 walks with 4 strikeouts on 4 hits through 6 innings pitched against the San Francisco Giants.

The current betting odds have the Mets listed as a favorite in this game according to Draftkings Sportsbook. The Mets have looked really good in their games this season with their 63-50 record overall which has them right near the top of the NL East. They have also looked great in their own ballpark this year with their 38-19 home record, one of the best home records in the entire MLB. Meanwhile, the Guardians have looked good in their games this season with their 57-55 record overall which has them right near the top of the AL Central. They haven't been a great road team though with their 28-28 road record. The Guardians have been getting hot now as they are 6-4 in their last 10 games, but they have still been really up and down this year and the Mets do have the better pitching matchup to take advantage of. Peterson is on the mound for the Mets in this one and he has looked great this season. He is 7-4 with a 2.83 ERA and he hasn't been giving up many runs lately. He is coming off another good start in which he gave up 2 earned runs and the team has won 2 of their last 3 games with him starting too. The Guardians are going with Williams in this one and he has looked good this season. He is 6-4 with a 3.33 ERA and hasn't been giving up many runs lately. He is coming off a great start in which he gave up no runs and his team has won 2 of their last 3 games with him starting too. As good as he has been this season, the Guardians have still struggled and a lot of that has to do with having one of the worst offenses in the MLB. They put up a lot of runs to beat the Mets on Monday, but that hasn't been a common theme for them this year and the Mets are going to respond at home where they have been so much better this season. The best way to place a bet here is on the Mets to win this game. 

Guardians Mets Prediction:  Our MLB Pick for Wednesday, August 6, 2025 (1:10 pm ET start time) is Mets 3 Royals 2.

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Cleveland Guardians: 105-118 (-6.8 units) on the moneyline in road games. 86-120 (-11.3 units) on the moneyline as an underdog of +100 or higher. 59-70 (-16.1 units) on the moneyline in an inter-league game. 4-0 OVER on the road against NL East opponents.

New York Mets: 130-94 (+7.4 units) on the moneyline in home games. 101-64 (+4.9 units) on the moneyline as a home favorite of -110 or higher. 174-143 (+13.7 units) on the moneyline against right-handed starters. 12-5 OVER at home vs. an AL starting pitcher whose ERA is 3.70 or better.

Cleveland Guardians:  L. Thomas (CF) Ten Day IL - Foot. W. Brennan (RF) Sixty Day IL - Forearm. A. Walters (RP) Sixty Day IL - Lat. B. Lively (SP) Sixty Day IL - Forearm. J. Means (SP) Sixty Day IL - Elbow. S. Hentges (RP) Sixty Day IL - Shoulder.

New York Mets:  J. Winker (LF) Sixty Day IL - Back. M. Kranick (RP) Sixty Day IL - Elbow. B. Waddell (RP) Fifteen Day IL - Hip. D. Nunez (RP) Sixty Day IL - Elbow. T. Megill (SP) Sixty Day IL - Elbow. P. Blackburn (SP) Fifteen Day IL - Shoulder. G. Canning (SP) Sixty Day IL - Achilles. J. Siri (CF) Sixty Day IL - Shin. D. Young (RP) Sixty Day IL - Elbow. A. Minter (RP) Sixty Day IL - Lat. C. Scott (SP) Sixty Day IL - Elbow. N. Madrigal (3B) Sixty Day IL - Shoulder. D. Smith (RP) Sixty Day IL - Elbow.

“What a cool night. His first career save. He was outstanding. Nic is such a great kid, what he has been through in his personal life, nothing is going to rattle him either. He has been so great for us, consistent. I’m just really happy for him and his family.” - Stephen Vogt after his team’s win against the Mets in their game on Monday. 

“I don’t want to get too far ahead. Right now, we’re talking about his next start, and that’s what we’ve got.” - Carlos Mendoza on Sean Manaea after his team’s loss against the Guardians in their game on Monday.

Steven Kwan (L) LF

Angel Martínez (S) CF

José Ramírez (S) 3B

David Fry (R) DH

Carlos Santana (S) 1B

Gabriel Arias (R) SS

Nolan Jones (L) RF

Brayan Rocchio (S) 2B

Austin Hedges (R) C

Brandon Nimmo (L) LF

Francisco Lindor (S) SS

Juan Soto (L) RF

Pete Alonso (R) DH

Jeff McNeil (L) 2B

Mark Vientos (R) 1B

Cedric Mullins (L) CF

Ronny Mauricio (S) 3B

Francisco Alvarez (R) C

Batting Average:  José Ramírez (.299)

Hits:  José Ramírez (123)

Home Runs:  José Ramírez (23)

RBI:  José Ramírez (61)

Stolen Bases:  José Ramírez (32)

Wins:  Logan Allen (7)

Saves:  Emmanuel Clase (24)

ERA:  Carlos Hernández (0.00)

Batting Average:  José Azocar (.278)

Hits:  Francisco Lindor (114)

Home Runs:  Juan Soto (25)

RBI:  Pete Alonso (90)

Stolen Bases:  Francisco Lindor (17)

Wins:  Clay Holmes (9)

Saves:  Edwin Díaz (23)

ERA:  Brooks Raley (0.00)

Managers:

Cleveland Guardians: Stephen Vogt (2nd season)

New York Mets: Carlos Mendoza (2nd season)