Chicago Cubs vs Minnesota Twins Prediction, Preview and Odds - 07/10/2025

Game Time: 1:10 pm ET, Thursday, July 10, 2025

Venue:  Target Field, Minneapolis, MN 

Where to Watch:  MLBN 

DraftKings:  Moneyline odds:  Cubs -110, Twins -110; Over/Under:  9.5 runs

Bet365:  Moneyline odds:  Cubs -110, Twins -110; Over/Under:  9.5 runs

BetMGM:  Moneyline odds:  Cubs -110, Twins -110; Over/Under:  9.5 runs

Chicago Cubs:  54-37 (1st place, NL Central)

Minnesota Twins:  44-47 (3rd place, AL Central)

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Chicago Cubs:  6-4 last 10

Minnesota Twins:  5-5 last 10

The Cubs are entering this series off a win and won their 3-game series against the St Louis Cardinals 2-1 in their last series. They enter this game with a 54-37 record overall and have a road record of 24-21. This is the series finale of a 3-game series with the Twins on Thursday with the 2nd game still to be played on Wednesday. The Cubs lost the series opener on Tuesday. Their offense ranks 3rd in the MLB with a .777 OPS. Rookie pitcher Cade Horton is their starting pitcher on Wednesday while Colin Rea is making his start in this game on Thursday. He is 6-3 with a 4.13 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 ER, 1 HR, and 2 BB with 4 SO on 2 hits through 6.2 IP against the St Louis Cardinals.

The Twins are entering this series off a loss and won their 3-game series against the Tampa Bay Rays 2-1 in their last series. They enter this game with a 44-47 record overall and have a home record of 25-18. This is the 3rd game of a 3-game series with the Cubs on Thursday with the 2nd game of this series still to be played on Wednesday. The Twins won the 1st game of this series on Tuesday. Their offense ranks 18th in the MLB with a .704 OPS. David Festa is their starting pitcher on Wednesday while Chris Paddack is making his start in this game on Thursday. He is 3-7 with a 4.64 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 0 homers, and 0 walks with 5 strikeouts on 5 hits through 5 innings pitched against the Tampa Bay Rays.

The current betting odds have the Cubs listed as a pick ‘em in this game according to Draftkings Sportsbook. The Cubs have looked great in their games this season with their 54-37 record overall which has them right at the top of the NL Central with one of the best records in the entire MLB. They have also been a good road team this year with their 24-21 road record. Meanwhile, the Twins haven't looked good in their games this season with their 44-47 record overall, but that record does have them near the top of the AL Central even though they aren't really in the division race. They have looked better in their own ballpark too with their 25-18 home record this season. The Cubs lost the 1st game of this series on Tuesday, but they have still been the hotter team lately. They also have one of the best offenses in the MLB and they can take advantage of the pitching matchup in this one. Rea is on the mound for the Cubs here and he hasn't looked great this season, but he has looked a lot better in his starts lately. He is 6-3 with a 4.13 ERA, but he hasn't been giving up many runs lately and the team has been having a lot of success with him. The team has won 2 games in a row now with him starting and he is coming off another great start in which he only gave up 1 earned run. The Twins are going with Paddack in this one and he hasn't looked great this season either. He is 3-7 with a 4.64 ERA this year, but he hasn't looked any better in his starts lately either. He only gave up 2 earned runs in his last start, but that hasn't been a common theme for him this year and the team has still lost 2 of their last 3 games with him starting too. All signs point to the Cubs taking this one. The best way to place a bet here is on the Cubs to win this game.  

Cubs Twins Prediction:  Our MLB Pick for Thursday, July 10, 2025 (1:10 pm ET start time) is Cubs 4 Twins 2.

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Chicago Cubs: 27-16 (+10 units) on the moneyline against AL Central opponents. 221-194 (+14.6 units) on the moneyline in all games. 166-139 (+23 units) on the moneyline against right-handed starters. 25-17 OVER against AL Central opponents.

Minnesota Twins: 19-26 (-14.3 units) on the moneyline against NL Central opponents. 216-205 (-35.4 units) on the moneyline in all games. 94-104 (-14.5 units) on the moneyline when the money line is +125 to -125. 36-18 OVER vs. a starting pitcher who gives up 1 or more HR's/start.

Chicago Cubs:  J. Taillon (SP) Fifteen Day IL - Calf. M. Amaya (C) Ten Day IL - Oblique. E. Morgan (RP) Sixty Day IL - Elbow. J. Assad (RP) Sixty Day IL - Oblique. J. Steele (SP) Sixty Day IL - Elbow.

Minnesota Twins:  B. Ober (SP) Fifteen Day IL - Hip. Z. Matthews (SP) Fifteen Day IL - Shoulder. P. Lopez (SP) Sixty Day IL - Shoulder. L. Keaschall (2B) Sixty Day IL - Forearm.

“He’s pitching like Shota does. And I don’t think he’s as good as he can be yet.” - Craig Counsell after his team’s loss against the Twins in their game on Tuesday.

“Everywhere you look our guys stepped up and did a nice job today.” - Rocco Baldelli after his team’s win against the Cubs in their game on Tuesday.

Ian Happ (S) LF

Kyle Tucker (L) RF

Seiya Suzuki (R) DH

Pete Crow-Armstrong (L) CF

Michael Busch (L) 1B

Dansby Swanson (R) SS

Carson Kelly (R) C

Nico Hoerner (R) 2B

Matt Shaw (R) 3B

Byron Buxton (R) CF

Ryan Jeffers (R) DH

Willi Castro (S) RF

Carlos Correa (R) SS

Royce Lewis (R) 3B

Harrison Bader (R) LF

Ty France (R) 1B

Brooks Lee (S) 2B

Christian Vázquez (R) C

Batting Average:  Michael Busch (.297)

Hits:  Kyle Tucker (96)

Home Runs:  Seiya Suzuki (25)

RBI:  Seiya Suzuki (77)

Stolen Bases:  Pete Crow-Armstrong (27)

Wins:  Matthew Boyd (9)

Saves:  Daniel Palencia (10)

ERA:  Michael Fulmer (0.00)

Batting Average:  Luke Keaschall (.368)

Hits:  Trevor Larnach (80)

Home Runs:  Byron Buxton (20)

RBI:  Byron Buxton (53)

Stolen Bases:  Byron Buxton (16)

Wins:  Joe Ryan (8)

Saves:  Jhoan Duran (13)

ERA:  Danny Coulombe (0.71)

Managers:

Chicago Cubs: Craig Counsell (2nd season)

Minnesota Twins: Rocco Baldelli (7th season)