Chicago Cubs vs Milwaukee Brewers Prediction, Preview and Odds - 07/30/2025

Game Time: 2:10 pm ET, Wednesday, July 30, 2025

Venue:  American Family Field, Milwaukee, WI 

Where to Watch:  MARQ, FDSWI

DraftKings:  Moneyline odds:  Cubs +101, Brewers -123; Over/Under:  7.5 runs

Bet365:  Moneyline odds:  Cubs +105, Brewers -125; Over/Under:  7.5 runs

BetMGM:  Moneyline odds:  Cubs +105, Brewers -125; Over/Under:  7.5 runs

Chicago Cubs:  62-44 (2nd place, NL Central)

Milwaukee Brewers:  63-43 (1st place, NL Central)

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Chicago Cubs:  5-5 last 10

Milwaukee Brewers:  7-3 last 10

The Cubs are entering this series off a win and won their 3-game series against the Chicago White Sox 2-1 in their last series. They enter this game with a 62-44 record overall and have a road record of 29-25. This is the series finale of a 3-game series with the Brewers on Wednesday with the 2nd game still to be played on Tuesday. The Cubs lost the series opener on Monday. Their offense ranks 3rd in the MLB with a .767 OPS. Colin Rea is their starting pitcher on Tuesday while Shota Imanaga is making his start in this game on Wednesday. He is 7-4 with a 3.12 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 7 ER, 3 HR, and 0 BB with 2 SO on 12 hits through 3 IP against the Chicago White Sox.

The Brewers are entering this series off a win and lost their 3-game series against the Miami Marlins 2-1 in their last series. They enter this game with a 63-43 record overall and have a home record of 35-19. This is the 3rd game of a 3-game series with the Cubs on Wednesday with the 2nd game of this series still to be played on Tuesday. The Brewers won the 1st game of this series on Monday. Their offense ranks 19th in the MLB with a .710 OPS. Quinn Priester is their starting pitcher on Tuesday while Freddy Peralta is making his start in this game on Wednesday. He is 12-4 with a 2.81 ERA this season. His team won 7 of their last 8 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 1 homer, and 2 walks with 9 strikeouts on 5 hits through 5 innings pitched against the Miami Marlins.

The current betting odds have the Brewers listed as a slight favorite in this game according to Draftkings Sportsbook. The Brewers have looked great in their games this season with their 63-43 record overall which has them right at the top of the NL Central with one of the best records in the entire MLB. They have also looked great in their own ballpark this year with their 35-19 home record. Meanwhile, the Cubs have looked great in their games this season with their 62-44 record overall which has them right at the top of the NL Central with one of the best records in the entire MLB. They have been a good road team too with their 29-25 road record this season. The Cubs have been rolling all season, leading the NL Central for most of the year, but lately they have been cooling off. They are only 5-5 in their last 10 games and have already lost the 1st game of this series while the Brewers are 7-3 in their last 10 games and have been hot. Peralta is starting for the Brewers in this one and he has been their ace this season. He is 12-4 with a 2.81 ERA and the team has had a ton of success with him. He is coming off another great start in which he only gave up 1 earned run and the team has won 7 of their last 8 games with him starting too. Imanaga is on the mound for the Cubs here and he has looked good this season too. He is 7-4 with a 3.12 ERA and the team has won 2 of their last 3 games with him starting. He is coming off a terrible start though, giving up 7 earned runs in only 3 innings against a bad White Sox team, and he isn't going to have it any easier on the road here against this hot Brewers offense. The Brewers can take advantage of his recent struggles while Peralta gives them another good outing here at home. The best way to place a bet here is on the Brewers to win this game. 

Cubs Brewers Prediction:  Our MLB Pick for Wednesday, July 30, 2025 (2:10 pm ET start time) is Brewers 4 Cubs 1.

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Chicago Cubs: 93-123 (-34.6 units) on the moneyline when the money line is +125 to -125. 92-83 (-7.2 units) on the moneyline vs. an NL team with a slugging percentage of .400 or worse on the season. 141-149 (-16.7 units) on the moneyline vs. a team with a good bullpen whose WHIP is 1.350 or better. 26-15 OVER on the road when playing against a good team (Win Pct. 54% to 62%).

Milwaukee Brewers: 249-187 (+42.3 units) on the moneyline in all games. 131-89 (+14 units) on the moneyline in home games. 129-93 (+36.5 units) on the moneyline when the money line is +125 to -125. 20-10 OVER at home vs. an NL starting pitcher whose ERA is 3.20 or better.

Chicago Cubs:  P. Hodge (RP) Fifteen Day IL - Shoulder. J. Taillon (SP) Fifteen Day IL - Calf. M. Amaya (C) Ten Day IL - Oblique. E. Morgan (RP) Sixty Day IL - Elbow. J. Assad (RP) Sixty Day IL - Oblique. J. Steele (SP) Sixty Day IL - Elbow.

Milwaukee Brewers:  J. Bauers (LF) Ten Day IL - Shoulder. R. Hoskins (1B) Ten Day IL - Thumb. G. Mitchell (CF) Sixty Day IL - Oblique. R. Zastryzny (RP) Fifteen Day IL - Ribs. N. Cortes (SP) Sixty Day IL - Elbow. C. Thomas (SP) Sixty Day IL - Elbow. R. Gasser (SP) Sixty Day IL - Elbow.

“What we do for a living is about competing. But his presence was almost due to kindness. And that’s such a rare [trait]. He was probably living at a higher level than the rest of us. I think that’s what he was known for. That’s what made him special. People like that make you better. They make you better people.” - Craig Counsell after his team’s loss against the Brewers in their game on Monday.

“I told him, ‘It was my favorite start you’ve had in the big leagues, honestly.' All the cruising and the ‘punchies’ and all that stuff is fun and exciting, but this shows you a lot about what he’s made of out there when it’s kind of hitting the fan on him.” - Christian Yelich after their win against the Cubs in their game on Monday.

Michael Busch (L) 1B

Kyle Tucker (L) RF

Seiya Suzuki (R) DH

Pete Crow-Armstrong (L) CF

Carson Kelly (R) C

Ian Happ (S) LF

Dansby Swanson (R) SS

Nico Hoerner (R) 2B

Matt Shaw (R) 3B

Sal Frelick (L) RF

Jackson Chourio (R) CF

William Contreras (R) C

Christian Yelich (L) DH

Andrew Vaughn (R) 1B

Isaac Collins (S) LF

Brice Turang (L) 2B

Caleb Durbin (R) 3B

Joey Ortiz (R) SS

Batting Average:  Nico Hoerner (.289)

Hits:  Nico Hoerner (112)

Home Runs:  Pete Crow-Armstrong (27)

RBI:  Seiya Suzuki (81)

Stolen Bases:  Pete Crow-Armstrong (29)

Wins:  Matthew Boyd (11)

Saves:  Daniel Palencia (14)

ERA:  Michael Fulmer (0.00)

Batting Average:  Andrew Vaughn (.341)

Hits:  Jackson Chourio (121)

Home Runs:  Christian Yelich (20)

RBI:  Christian Yelich (69)

Stolen Bases:  Brice Turang (19)

Wins:  Freddy Peralta (12)

Saves:  Trevor Megill (24)

ERA:  Logan Henderson (1.71)

Managers:

Chicago Cubs: Craig Counsell (2nd season)

Milwaukee Brewers: Pat Murphy (2nd season)