Chicago Cubs vs Milwaukee Brewers Prediction, Preview and Odds - 07/29/2025

Game Time: 7:40 pm ET, Tuesday, July 29, 2025

Venue:  American Family Field, Milwaukee, WI 

Where to Watch:  MARQ, FDSWI

DraftKings:  Moneyline odds:  Cubs -101, Brewers -119; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Cubs +100, Brewers -120; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Cubs +100, Brewers -120; Over/Under:  8.5 runs

Chicago Cubs:  62-43 (1st place, NL Central)

Milwaukee Brewers:  62-43 (2nd place, NL Central)

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Chicago Cubs:  6-4 last 10

Milwaukee Brewers:  7-3 last 10

The Cubs are entering this series off a win and won their 3-game series against the Chicago White Sox 2-1 in their last series. They enter this game with a 62-43 record overall and have a road record of 29-24. This is the 2nd game of a 3-game series with the Brewers on Tuesday with the series opener still to be played on Monday. Their offense ranks 3rd in the MLB with a .769 OPS. Matthew Boyd is their starting pitcher on Monday while Colin Rea is making his start in this game on Tuesday. He is 8-4 with a 4.06 ERA this season. His team won 4 of their last 5 games this season with him making an appearance. In his last MLB regular season start, he allowed 5 ER, 3 HR, and 0 BB with 3 SO on 6 hits through 5 IP against the Kansas City Royals.

The Brewers are entering this series off a win and lost their 3-game series against the Miami Marlins 2-1 in their last series. They enter this game with a 62-43 record overall and have a home record of 34-19. This is the 2nd game of a 3-game series with the Cubs on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 19th in the MLB with a .708 OPS. Rookie pitcher Jacob Misiorowski is their starting pitcher on Monday while Quinn Priester is making his start in this game on Tuesday. He is 9-2 with a 3.28 ERA this season. His team won their last 10 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 0 homers, and 2 walks with 6 strikeouts on 6 hits through 7 innings pitched against the Seattle Mariners.

The current betting odds have the Brewers listed as a slight favorite in this game according to Draftkings Sportsbook. The Brewers have looked great in their games this season with their 62-43 record overall which has them right at the top of the NL Central with one of the best records in the entire MLB. They have also looked great in their own ballpark this year with their 34-19 home record. Meanwhile, the Cubs have looked great in their games this season with their 62-43 record overall which has them right at the top of the NL Central with one of the best records in the entire MLB. They have been a good road team too with their 29-24 road record this season. Both teams have been really hot lately too, the Cubs going 6-4 in their last 10 games while the Brewers are 7-3, but the Brewers do have the slightly better pitching matchup here to take advantage of at home where they have looked so much better this season. Priester is on the mound for the Brewers in this one and he has looked great this year. He is 9-2 with a 3.28 ERA and the team has had a ton of success with him starting. He is coming off another good start in which he gave up 2 earned runs and the team has won 10 games in a row now with him starting too. The Cubs are going with Rea in this one and he has looked good this season, but he was shaky to start the season and has started to give up more runs in his starts lately too. He is 8-4 with a 4.06 ERA and the team has been having success with him on the mound. They have won 4 of their last 5 games with him starting, but he did give up 5 earned runs in his last start and he will get himself into trouble with the way this Brewers offense has been lately. The Cubs have been rolling all season, but the Brewers have been the hotter team lately and they have the slight edge at home with their pitching. The best way to place a bet here is on the Brewers to win this game. 

Cubs Brewers Prediction:  Our MLB Pick for Tuesday, July 29, 2025 (7:40 pm ET start time) is Brewers 2 Cubs 1.

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Chicago Cubs: 93-122 (-33.6 units) on the moneyline when the money line is +125 to -125. 92-82 (-6.2 units) on the moneyline vs. an NL team with a slugging percentage of .400 or worse on the season. 141-148 (-15.7 units) on the moneyline vs. a team with a good bullpen whose WHIP is 1.350 or better. 6-3 UNDER on the road in the second half of the season.

Milwaukee Brewers: 248-187 (+41.3 units) on the moneyline in all games. 130-89 (+13 units) on the moneyline in home games. 128-93 (+35.5 units) on the moneyline when the money line is +125 to -125. 21-11 UNDER at home when the total is 8 to 8.5.

Chicago Cubs:  P. Hodge (RP) Fifteen Day IL - Shoulder. J. Taillon (SP) Fifteen Day IL - Calf. M. Amaya (C) Ten Day IL - Oblique. E. Morgan (RP) Sixty Day IL - Elbow. J. Assad (RP) Sixty Day IL - Oblique. J. Steele (SP) Sixty Day IL - Elbow.

Milwaukee Brewers:  N. Mears (RP) Day To Day - Back. J. Bauers (LF) Ten Day IL - Shoulder. R. Hoskins (1B) Ten Day IL - Thumb. G. Mitchell (CF) Sixty Day IL - Oblique. R. Zastryzny (RP) Fifteen Day IL - Ribs. N. Cortes (SP) Sixty Day IL - Elbow. C. Thomas (SP) Sixty Day IL - Elbow. R. Gasser (SP) Sixty Day IL - Elbow.

“He gave us exactly what we needed, and he came up big time. I was hoping for, frankly, 12 outs, and he got us 15 outs. So, he did a heck of a job. He threw a lot of strikes, played well behind, so job well done for sure.” - Craig Counsell after his team’s win against the White Sox in their game on Sunday.

“It was emotional for me to see Perk come through right there. That was huge.” - Pat Murphy after his team’s win against the Marlins in their game on Sunday.

Michael Busch (L) 1B

Kyle Tucker (L) RF

Seiya Suzuki (R) DH

Pete Crow-Armstrong (L) CF

Carson Kelly (R) C

Ian Happ (S) LF

Dansby Swanson (R) SS

Nico Hoerner (R) 2B

Matt Shaw (R) 3B

Brice Turang (L) 2B

Jackson Chourio (R) CF

William Contreras (R) DH

Christian Yelich (L) LF

Andrew Vaughn (R) 1B

Isaac Collins (S) RF

Caleb Durbin (R) 3B

Joey Ortiz (R) SS

Eric Haase (R) C

Batting Average:  Nico Hoerner (.289)

Hits:  Nico Hoerner (111)

Home Runs:  Pete Crow-Armstrong (27)

RBI:  Seiya Suzuki (81)

Stolen Bases:  Pete Crow-Armstrong (29)

Wins:  Matthew Boyd (11)

Saves:  Daniel Palencia (14)

ERA:  Michael Fulmer (0.00)

Batting Average:  Andrew Vaughn (.341)

Hits:  Jackson Chourio (121)

Home Runs:  Christian Yelich (19)

RBI:  Jackson Chourio (67)

Stolen Bases:  Brice Turang (19)

Wins:  Freddy Peralta (12)

Saves:  Trevor Megill (23)

ERA:  Logan Henderson (1.71)

Managers:

Chicago Cubs: Craig Counsell (2nd season)

Milwaukee Brewers: Pat Murphy (2nd season)