Boston Red Sox vs Philadelphia Phillies Prediction, Preview and Odds - 07/22/2025

Game Time: 6:45 pm ET, Tuesday, July 22, 2025

Venue:  Citizens Bank Park, Philadelphia, PA 

Where to Watch:  TBS, MAX, truTV

DraftKings:  Moneyline odds:  Red Sox +168, Phillies -208; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Red Sox +170, Phillies -210; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Red Sox +170, Phillies -210; Over/Under:  8.5 runs

Boston Red Sox:  54-47 (3rd place, AL East)

Philadelphia Phillies:  56-43 (1st place, NL East)

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Boston Red Sox:  8-2 last 10

Philadelphia Phillies:  4-6 last 10

The Red Sox are entering this series off a win and lost their 3-game series against the Chicago Cubs 2-1 in their last series. They enter this game with a 54-47 record overall and have a road record of 22-27. This is the 2nd game of a 3-game series with the Phillies on Tuesday with the series opener still to be played on Monday. Their offense ranks 5th in the MLB with a .755 OPS. Walker Buehler is their starting pitcher on Monday while Richard Fitts is making his start in this game on Tuesday. He is 1-3 with a 4.28 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 2 ER, 0 HR, and 1 BB with 6 SO on 5 hits through 5.2 IP against the Colorado Rockies.

The Phillies are entering this series off a loss and lost their 3-game series against the Los Angeles Angels 2-1 in their last series. They enter this game with a 56-43 record overall and have a home record of 31-18. This is the 2nd game of a 3-game series with the Red Sox on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 11th in the MLB with a .733 OPS. Zack Wheeler is their starting pitcher on Monday while Cristopher Sánchez is making his start in this game on Tuesday. He is 8-2 with a 2.50 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 3 walks with 6 strikeouts on 6 hits through 7.1 innings pitched against the San Diego Padres.

The current betting odds have the Phillies listed as a big favorite in this game according to Draftkings Sportsbook. The Phillies have looked great in their games this season with their 56-43 record overall which has them right at the top of the NL East. They have also looked great in their own ballpark this year with their 31-18 home record. Meanwhile, the Red Sox have looked good in their games this season with their 54-47 record overall which has them right in the middle of the AL East. They haven't been a good road team though with their 22-27 road record this season. The Red Sox have been the much hotter team lately as they are 8-2 in their last 10 games while the Phillies are only 4-6, but the Phillies do have the better pitching matchup here and they can take advantage of that. The Phillies are going with Sanchez in this one and he has looked great this season. He is 8-2 with a 2.50 ERA and hasn't been giving up many runs lately. He only gave up 1 earned run in his last start and the team has won 2 of their last 3 games with him starting too. The Red Sox are going with Fitts in this one and he hasn't looked great this year. He is 1-3 with a 4.28 ERA and has been really up and down in his starts. The team has won 2 games in a row now with him starting and he only gave up 2 earned runs in his last start too, but the team has also been so hot lately and starts like that haven't been a common theme for him this year. The Red Sox also cooled off coming out of the break with 2 losses in their 3 games against the Cubs so this is a good series for the Phillies to bounce back at home as the Red Sox start to cool off now. The best way to place a bet here is on the Phillies to win this game and on the runline.

Red Sox Phillies Prediction:  Our MLB Pick for Tuesday, July 22, 2025 (6:45 pm ET start time) is Phillies 5 Red Sox 2.

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Boston Red Sox: 212-212 (-16.7 units) on the moneyline in all games. 59-64 (-11.7 units) on the moneyline in an inter-league game. 54-58 (-7.8 units) on the moneyline against left-handed starters. 25-18 UNDER against NL East opponents.

Philadelphia Phillies: 25-16 (+7.3 units) on the moneyline against AL East opponents. 142-80 (+22.2 units) on the moneyline in home games. 202-121 (+15.3 units) on the moneyline as a favorite of -110 or higher. 42-29 UNDER vs. a team with a good bullpen whose ERA is 3.45 or better.

Boston Red Sox:  H. Dobbins (SP) Fifteen Day IL - ACL. N. Burdi (RP) Sixty Day IL - Knee. L. Hendriks (RP) Sixty Day IL - Hip. Z. Kelly (RP) Fifteen Day IL - Oblique. L. Guerrero (RP) Fifteen Day IL - Elbow. J. Slaten (RP) Sixty Day IL - Shoulder. J. Winckowski (RP) Sixty Day IL - Elbow. T. Casas (1B) Sixty Day IL - Knee. K. Crawford (SP) Sixty Day IL - Knee. T. Houck (SP) Fifteen Day IL - Flexor. P. Sandoval (SP) Sixty Day IL - Elbow.

Philadelphia Phillies:  A. Bohm (3B) Ten Day IL - Ribcage. A. Nola (SP) Sixty Day IL - Ankle.

“He tries to bunt, trying to get on base because the third baseman was playing in the shortstop position. We like it, [and] we don’t like it. It doesn't matter. He’s trying to get on base. And then he got a good pitch and pulled it in the air. Wily’s a good player, a good defender and a good hitter.” - Alex Cora after his team’s win against the Cubs in their game on Sunday.

"He's battled. I feel for him for last year and all the stuff that he went through. And then this year, he's done everything that we've asked him to do. Along the way, whatever situation he's been in, he's thrown the ball pretty well." - Rob Thomson on Taijuan Walker this season. 

Jarren Duran (L) CF

Roman Anthony (L) DH

Ceddanne Rafaela (R) 2B

Masataka Yoshida (L) LF

Trevor Story (R) SS

Wilyer Abreu (L) RF

Carlos Narváez (R) C

Marcelo Mayer (L) 3B

Romy Gonzalez (R) 1B

Trea Turner (R) SS

Kyle Schwarber (L) DH

Bryce Harper (L) 1B

Nick Castellanos (R) RF

Brandon Marsh (L) CF

Otto Kemp (R) 3B

Max Kepler (L) LF

Rafael Marchán (S) C

Bryson Stott (L) 2B

Batting Average:  Romy Gonzalez (.311)

Hits:  Jarren Duran (104)

Home Runs:  Wilyer Abreu (20)

RBI:  Trevor Story (58)

Stolen Bases:  Jarren Duran (16)

Wins:  Garrett Crochet (11)

Saves:  Aroldis Chapman (17)

ERA:  Nick Burdi (0.00)

Batting Average:  Trea Turner (.288)

Hits:  Trea Turner (115)

Home Runs:  Kyle Schwarber (32)

RBI:  Kyle Schwarber (74)

Stolen Bases:  Trea Turner (25)

Wins:  Zack Wheeler (9)

Saves:  Jordan Romano (8)

ERA:  Daniel Robert (1.50)

Managers:

Boston Red Sox: Álex Cora (5th season)

Philadelphia Phillies: Rob Thomson (4th season)