Arizona Diamondbacks vs Detroit Tigers Prediction, Preview and Odds - 07/30/2025

Game Time: 1:10 pm ET, Wednesday, July 30, 2025

Venue:  Comerica Park, Detroit, MI 

Where to Watch:  MLBN

DraftKings:  Moneyline odds:  Diamondbacks +112, Tigers -137; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Diamondbacks +115, Tigers -140; Over/Under:  9 runs

BetMGM:  Moneyline odds:  Diamondbacks +115, Tigers -140; Over/Under:  9 runs

Arizona Diamondbacks:  51-56 (4th place, NL West)

Detroit Tigers:  62-46 (1st place, AL Central)

Do not miss out on our expert handicapper analysis! Matt Fargo is on a HOT STREAK in the MLB on a 13-4 MLB RUN for +$12,760 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Arizona Diamondbacks:  4-6 last 10

Detroit Tigers:  3-7 last 10

The Diamondbacks are entering this series off a loss and lost their 3-game series against the Pittsburgh Pirates 2-1 in their last series. They enter this game with a 51-56 record overall and have a road record of 25-28. This is the series finale of a 3-game series with the Tigers on Wednesday with the 2nd game still to be played on Tuesday. The Diamondbacks lost the series opener on Monday. Their offense ranks 4th in the MLB with a .763 OPS. Brandon Pfaadt is their starting pitcher on Tuesday while Ryne Nelson is making his start in this game on Wednesday. He is 6-2 with a 3.29 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 0 ER, 0 HR, and 2 BB with 4 SO on 1 hit through 6 IP against the Pittsburgh Pirates.

The Tigers are entering this series off a win and lost their 4-game series against the Toronto Blue Jays 3-1 in their last series. They enter this game with a 62-46 record overall and have a home record of 34-21. This is the 3rd game of a 3-game series with the Diamondbacks on Wednesday with the 2nd game of this series still to be played on Tuesday. The Tigers won the 1st game of this series on Monday. Their offense ranks 10th in the MLB with a .732 OPS. Casey Mize is their starting pitcher on Tuesday while Chris Paddack is making his start in this game on Wednesday. He is 3-9 with a 4.95 ERA this season. His team lost their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 1 homer, and 0 walks with 8 strikeouts on 4 hits through 6 innings pitched against the Los Angeles Dodgers.

The current betting odds have the Diamondbacks listed as an underdog in this game according to Draftkings Sportsbook. The Tigers have looked great in their games this season with their 62-46 record overall which has them right at the top of the AL Central with one of the best records in the entire MLB. They have also looked great in their own ballpark this year with their 34-21 home record. Meanwhile, the Diamondbacks haven't looked good in their games this season with their 51-56 record overall which has them right near the bottom of the NL West. They haven't been a great road team either with their 25-28 road record this season. The Diamondbacks haven't looked great lately as they are 4-6 in their last 10 games, but the Tigers have still been worse lately as they are 3-7 in their last 10 games. The Diamondbacks also have the better pitching matchup here to take advantage of and one of the best offenses in the MLB. The Diamondbacks are going with Nelson in this one and he has looked great this season. He is 6-2 with a 3.29 ERA and hasn't been giving up many runs all year. He is coming off another great start in which he gave up no runs, something that has been a common theme for him, and the team has won 2 games in a row now with him starting too. The Tigers are going with newly acquired starter Paddack in this one, but he hasn't looked great this season. He is 3-9 with a 4.95 ERA and has been giving up a ton of runs all year with the Twins. He only gave up 1 earned run in his last start, but that hasn't been a common theme for him lately and his team still lost their last 3 games with him starting. The Diamondbacks have the better offense to take advantage of this pitching matchup and they are still catching the Tigers in the middle of a slump too. The best way to place a bet here is on the Diamondbacks to win this game. 

Diamondbacks Tigers Prediction:  Our MLB Pick for Wednesday, July 30, 2025 (1:10 pm ET start time) is Diamondbacks 8 Tigers 3.

Don't miss our champion handicappers free picks, best bets, and expert baseball picks today.  And if you enjoyed this Arizona Diamondbacks Detroit Tigers prediction, be sure to drop by every day for our daily MLB projections and previews.

Arizona Diamondbacks: 59-66 (-13.7 units) on the moneyline in an inter-league game. 51-58 (-14.2 units) on the moneyline vs. an AL team with an on base percentage .330 or worse. 49-61 (-9.1 units) on the moneyline when playing against a good team (Win Pct. 54% to 62%). 6-3 OVER vs. a starting pitcher whose winning percentage is worse than 30%.

Detroit Tigers: 24-19 (+6.8 units) on the moneyline against NL West opponents. 230-210 (+29.5 units) on the moneyline in all games. 110-66 (+13.3 units) on the moneyline as a favorite of -110 or higher. 34-18 OVER vs. NL teams allowing 4.5 or more runs/game on the season.

Arizona Diamondbacks:  E. Suarez (3B) Day To Day - Hand. G. Moreno (C) Sixty Day IL - Hand. J. Beeks (RP) Fifteen Day IL - Back. S. Miller (RP) Fifteen Day IL - Forearm. P. Smith (1B) Ten Day IL - Oblique. T. Henry (RP) Sixty Day IL - Elbow. R. Thompson (RP) Fifteen Day IL - Scapular Strain. I. Vargas (2B) Ten Day IL - Foot. C. Montes De Oca (RP) Sixty Day IL - Elbow. J. Martinez (RP) Sixty Day IL - Elbow. C. Mena (SP) Sixty Day IL - Shoulder. C. Burnes (SP) Sixty Day IL - Elbow. A. Puk (RP) Sixty Day IL - Elbow. J. Montgomery (SP) Sixty Day IL - Elbow. B. Walston (SP) Sixty Day IL - Elbow.

Detroit Tigers:  R. Olson (SP) Sixty Day IL - Shoulder. P. Meadows (CF) Ten Day IL - Quad. S. Guenther (RP) Sixty Day IL - Hip. S. Gipson-Long (SP) Fifteen Day IL - Neck. J. Jobe (SP) Sixty Day IL - Flexor. J. Foley (RP) Sixty Day IL - Shoulder. A. Cobb (SP) Sixty Day IL - Hip. T. Madden (SP) Sixty Day IL - Shoulder. J. Urquidy (SP) Sixty Day IL - Elbow. A. Lange (RP) Sixty Day IL - Lat.

“It's part of the game, and I don't think Vest is trying to hit anybody there, let alone one of the most impressive hitters in MLB. You don't want to do those types of things and get those types of players off the field. They need to be on the field performing. [Suárez is] just a great story this season. So for sure, I don't think there was any intent.” - Torey Lovullo on the injury to Eugenio Suarez after his team’s loss against the Tigers in their game on Monday.

“I think early in his outing in Pittsburgh, he was jumping off the rubber a little bit, he was doing a little bit too much. But generally speaking, because he has a calm heartbeat, he can execute a game plan. And with all of the different options that he and Ding had to go to against this lineup, he can generate a lot of quick outs and also escape some issues because of the power in his stuff.” - A.J. Hinch after his team’s win against the Diamondbacks in their game on Monday.

Corbin Carroll (L) RF

Ketel Marte (S) 2B

Geraldo Perdomo (S) SS

Eugenio Suárez (R) 3B

Adrian Del Castillo (L) DH

Lourdes Gurriel Jr. (R) LF

Tristin English (R) 1B

Alek Thomas (L) CF

Jose Herrera (S) C

Matt Vierling (R) CF

Gleyber Torres (R) 2B

Jahmai Jones (R) DH

Spencer Torkelson (R) 1B

Riley Greene (L) LF

Andy Ibáñez (R) 3B

Dillon Dingler (R) C

Wenceel Pérez (S) RF

Javier Báez (R) SS

Batting Average:  James McCann (.310)

Hits:  Geraldo Perdomo (106)

Home Runs:  Eugenio Suárez (36)

RBI:  Eugenio Suárez (87)

Stolen Bases:  Geraldo Perdomo (15)

Wins:  Brandon Pfaadt (10)

Saves:  Shelby Miller (10)

ERA:  Christian Montes De Oca (0.00)

Batting Average:  Brewer Hicklen (.667)

Hits:  Riley Greene (110)

Home Runs:  Riley Greene (25)

RBI:  Riley Greene (81)

Stolen Bases:  Zach McKinstry (16)

Wins:  Tarik Skubal (10)

Saves:  Will Vest (16)

ERA:  Dylan Smith (1.38)

Managers:

Arizona Diamondbacks: Torey Lovullo (9th season)

Detroit Tigers: A.J. Hinch (5th season)