Arizona Diamondbacks vs Detroit Tigers Prediction, Preview and Odds - 07/29/2025

Game Time: 6:40 pm ET, Tuesday, July 29, 2025

Venue:  Comerica Park, Detroit, MI 

Where to Watch:  DBACKS.tv, FDSD

DraftKings:  Moneyline odds:  Diamondbacks +119, Tigers -145; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Diamondbacks +120, Tigers -140; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Diamondbacks +120, Tigers -140; Over/Under:  8.5 runs

Arizona Diamondbacks:  51-55 (4th place, NL West)

Detroit Tigers:  61-46 (1st place, AL Central)

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Arizona Diamondbacks:  5-5 last 10

Detroit Tigers:  2-8 last 10

The Diamondbacks are entering this series off a loss and lost their 3-game series against the Pittsburgh Pirates 2-1 in their last series. They enter this game with a 51-55 record overall and have a road record of 25-27. This is the 2nd game of a 3-game series with the Tigers on Tuesday with the series opener still to be played on Monday. Their offense ranks 4th in the MLB with a .764 OPS. Eduardo Rodríguez is their starting pitcher on Monday while Brandon Pfaadt is making his start in this game on Tuesday. He is 10-6 with a 4.76 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 2 ER, 0 HR, and 2 BB with 5 SO on 5 hits through 5.1 IP against the Houston Astros.

The Tigers are entering this series off a win and lost their 4-game series against the Toronto Blue Jays 3-1 in their last series. They enter this game with a 61-46 record overall and have a home record of 33-21. This is the 2nd game of a 3-game series with the Diamondbacks on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 11th in the MLB with a .730 OPS. Rookie pitcher Troy Melton is their starting pitcher on Monday while Casey Mize is making his start in this game on Tuesday. He is 9-4 with a 3.40 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 4 earned runs, 0 homers, and 1 walk with 5 strikeouts on 10 hits through 4 innings pitched against the Pittsburgh Pirates.

The current betting odds have the Tigers listed as a favorite in this game according to Draftkings Sportsbook. The Tigers have looked great in their games this season with their 61-46 record overall which has them right at the top of the AL Central with one of the best records in the entire MLB. They have also looked great in their own ballpark this year with their 33-21 home record. Meanwhile, the Diamondbacks haven't looked good in their games this season with their 51-55 record overall which has them right near the bottom of the NL West. They haven't been a great road team either with their 25-27 road record this season. The Diamondbacks are only 5-5 in their last 10 games, but they have been the hotter team lately as the Tigers are 2-8 in their last 10 games and have been slumping lately. The Tigers do have the better pitching matchup though and they are going to bring their best effort here at home as they are in desperate need of a bounce back win. Mize is on the mound for the Tigers and he has been a solid starter for them this season. He is 9-4 with a 3.40 ERA and the team has had a ton of success with him all year. They have lost 2 games in a row now with him starting and he did give up 4 earned runs in his last start, but that hasn't been a common theme for him and he will be looking to bounce back. The Diamondbacks are going with Pfaadt in this one and he has looked good this season. He is 10-6 with a 4.76 ERA and the team has won 2 of their last 3 games with him starting. They have a lot of success with him this year and he only gave up 2 earned runs in his last start, but that hasn't been a common theme for him as he has been giving up quite a few runs in his starts all season. The Diamondbacks do have one of the best offenses in the MLB to help out, but they haven't been putting up many runs lately while the Tigers also have a good offense and are starting to break out of their funk. The best way to place a bet here is on the Tigers to win this game. 

Diamondbacks Tigers Prediction:  Our MLB Pick for Tuesday, July 29, 2025 (6:40 pm ET start time) is Tigers 5 Diamondbacks 4.

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Arizona Diamondbacks: 59-65 (-12.7 units) on the moneyline in an inter-league game. 51-57 (-13.2 units) on the moneyline vs. an AL team with an on base percentage .330 or worse. 49-60 (-8.1 units) on the moneyline when playing against a good team (Win Pct. 54% to 62%). 11-4 OVER on the road vs. an AL starting pitcher whose ERA is 3.70 or better.

Detroit Tigers: 23-19 (+5.8 units) on the moneyline against NL West opponents. 229-210 (+28.5 units) on the moneyline in all games. 109-66 (+12.3 units) on the moneyline as a favorite of -110 or higher. 34-17 OVER vs. NL teams allowing 4.5 or more runs/game on the season.

Arizona Diamondbacks:  G. Moreno (C) Sixty Day IL - Hand. J. Beeks (RP) Fifteen Day IL - Back. S. Miller (RP) Fifteen Day IL - Forearm. P. Smith (1B) Ten Day IL - Oblique. T. Henry (RP) Sixty Day IL - Elbow. R. Thompson (RP) Fifteen Day IL - Scapular Strain. I. Vargas (2B) Ten Day IL - Foot. C. Montes De Oca (RP) Sixty Day IL - Elbow. J. Martinez (RP) Sixty Day IL - Elbow. C. Mena (SP) Sixty Day IL - Shoulder. C. Burnes (SP) Sixty Day IL - Elbow. A. Puk (RP) Sixty Day IL - Elbow. J. Montgomery (SP) Sixty Day IL - Elbow. B. Walston (SP) Sixty Day IL - Elbow.

Detroit Tigers:  S. Guenther (RP) Sixty Day IL - Hip. S. Gipson-Long (SP) Fifteen Day IL - Neck. J. Jobe (SP) Sixty Day IL - Flexor. J. Foley (RP) Sixty Day IL - Shoulder. A. Cobb (SP) Sixty Day IL - Hip. T. Madden (SP) Sixty Day IL - Shoulder. J. Urquidy (SP) Sixty Day IL - Elbow. A. Lange (RP) Sixty Day IL - Lat.

“It is what it is. I think obviously for me, I would have loved -- if today was the last one -- to have it go a little bit better, maybe get a win, but it is what it is. This year has been tough for me, frustrating. At the end of the day, I still came to work, still brought my lunch box and tried to turn over every stone I could to help the team win. Hopefully this isn't the last [start], hopefully I got 10-12 more, or whatever, and try to go on a run. But if it is, I did what I could.” - Zac Gallen on the trade deadline after their loss against the Pirates in their game on Sunday.

“Generally speaking, we’re willing to do anything. I can’t grow [a mustache] fast enough, but I see our boys are resorting to desperate times/desperate measures.” - A.J. Hinch after his team’s win against the Blue Jays in their game on Sunday.

Corbin Carroll (L) RF

Ketel Marte (S) 2B

Geraldo Perdomo (S) SS

Eugenio Suárez (R) 3B

Adrian Del Castillo (L) DH

Jake McCarthy (L) LF

James McCann (R) C

Alek Thomas (L) CF

Tristin English (R) 1B

Colt Keith (L) DH

Gleyber Torres (R) 2B

Kerry Carpenter (L) RF

Riley Greene (L) LF

Spencer Torkelson (R) 1B

Zach McKinstry (L) 3B

Dillon Dingler (R) C

Parker Meadows (L) CF

Javier Báez (R) SS

Batting Average:  Adrian Del Castillo (.318)

Hits:  Geraldo Perdomo (106)

Home Runs:  Eugenio Suárez (36)

RBI:  Eugenio Suárez (87)

Stolen Bases:  Geraldo Perdomo (15)

Wins:  Brandon Pfaadt (10)

Saves:  Shelby Miller (10)

ERA:  Christian Montes De Oca (0.00)

Batting Average:  Brewer Hicklen (.667)

Hits:  Riley Greene (110)

Home Runs:  Riley Greene (25)

RBI:  Riley Greene (81)

Stolen Bases:  Zach McKinstry (16)

Wins:  Tarik Skubal (10)

Saves:  Will Vest (16)

ERA:  Dylan Smith (1.38)

Managers:

Arizona Diamondbacks: Torey Lovullo (9th season)

Detroit Tigers: A.J. Hinch (5th season)